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Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting proficient meristem development

(2007) PLANT JOURNAL. 52(5). p.850-864
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Abstract
The Arabidopsis thaliana genome expresses five evolutionarily conserved prohibitin (PHB) genes that are divided into type-I (AtPHB3 and AtPHB4) and type-II (AtPHB1, AtPHB2 and AtPHB6) classes, based on their phylogenetic relationships with yeast PHB1 and PHB2, respectively. Yeast and animal PHBs are reported to have diverse roles in the cell cycle, mitochondrial electron transport, aging and apoptosis. All transcribed Arabidopsis PHB genes are primarily expressed in both shoot and root proliferative tissues, where they are present in mitochondrial multimeric complexes. Loss of function of the type-I AtPHB4 had no phenotypic effects, while loss of function of the homologous AtPHB3 caused mitochondrial swelling, decreased meristematic cell production, increased cell division time and reduced cell expansion rates, leading to severe growth retardation. Double knockout atphb3 atphb4 plants were not viable, but transgenic lines overexpressing AtPHB3 or AtPHB4 showed leaf shape aberrations and an increased shoot branching phenotype. Genome-wide microarray analysis revealed that both knockout and overexpression perturbations of AtPHB3 and AtPHB4 provoked an altered abundance of mitochondrial and stress-related transcripts. We propose that plant type-I PHBs take part in protein complexes that are necessary for proficient mitochondrial function or biogenesis, thereby supporting cell division and differentiation in apical tissues.
Keywords
IDENTIFICATION, TARGET, PLANTS, GROWTH, PROMOTER, GENES, EXPRESSION, PROTEIN, CELL-DIVISION, LATERAL ROOT INITIATION, cell division, development, mitochondria, Arabidopsis, prohibitins

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Chicago
Van Aken, Olivier, Tamara Pecenkova, Brigitte Van De Cotte, Riet De Rycke, Dominique Eeckhout, Hillel Fromm, Geert De Jaeger, et al. 2007. “Mitochondrial type-I Prohibitins of Arabidopsis Thaliana Are Required for Supporting Proficient Meristem Development.” Plant Journal 52 (5): 850–864.
APA
Van Aken, O., Pecenkova, T., Van De Cotte, B., De Rycke, R., Eeckhout, D., Fromm, H., De Jaeger, G., et al. (2007). Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting proficient meristem development. PLANT JOURNAL, 52(5), 850–864.
Vancouver
1.
Van Aken O, Pecenkova T, Van De Cotte B, De Rycke R, Eeckhout D, Fromm H, et al. Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting proficient meristem development. PLANT JOURNAL. 2007;52(5):850–64.
MLA
Van Aken, Olivier, Tamara Pecenkova, Brigitte Van De Cotte, et al. “Mitochondrial type-I Prohibitins of Arabidopsis Thaliana Are Required for Supporting Proficient Meristem Development.” PLANT JOURNAL 52.5 (2007): 850–864. Print.
@article{414459,
  abstract     = {The Arabidopsis thaliana genome expresses five evolutionarily conserved prohibitin (PHB) genes that are divided into type-I (AtPHB3 and AtPHB4) and type-II (AtPHB1, AtPHB2 and AtPHB6) classes, based on their phylogenetic relationships with yeast PHB1 and PHB2, respectively. Yeast and animal PHBs are reported to have diverse roles in the cell cycle, mitochondrial electron transport, aging and apoptosis. All transcribed Arabidopsis PHB genes are primarily expressed in both shoot and root proliferative tissues, where they are present in mitochondrial multimeric complexes. Loss of function of the type-I AtPHB4 had no phenotypic effects, while loss of function of the homologous AtPHB3 caused mitochondrial swelling, decreased meristematic cell production, increased cell division time and reduced cell expansion rates, leading to severe growth retardation. Double knockout atphb3 atphb4 plants were not viable, but transgenic lines overexpressing AtPHB3 or AtPHB4 showed leaf shape aberrations and an increased shoot branching phenotype. Genome-wide microarray analysis revealed that both knockout and overexpression perturbations of AtPHB3 and AtPHB4 provoked an altered abundance of mitochondrial and stress-related transcripts. We propose that plant type-I PHBs take part in protein complexes that are necessary for proficient mitochondrial function or biogenesis, thereby supporting cell division and differentiation in apical tissues.},
  author       = {Van Aken, Olivier and Pecenkova, Tamara and Van De Cotte, Brigitte and De Rycke, Riet and Eeckhout, Dominique and Fromm, Hillel and De Jaeger, Geert and Witters, Erwin and Beemster, Gerrit and Inz{\'e}, Dirk and Van Breusegem, Frank},
  issn         = {0960-7412},
  journal      = {PLANT JOURNAL},
  keyword      = {IDENTIFICATION,TARGET,PLANTS,GROWTH,PROMOTER,GENES,EXPRESSION,PROTEIN,CELL-DIVISION,LATERAL ROOT INITIATION,cell division,development,mitochondria,Arabidopsis,prohibitins},
  language     = {eng},
  number       = {5},
  pages        = {850--864},
  title        = {Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting proficient meristem development},
  url          = {http://dx.doi.org/10.1111/j.1365-313X.2007.03276.x},
  volume       = {52},
  year         = {2007},
}

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