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Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting proficient meristem development

Olivier Van Aken UGent, Tamara Pecenkova, Brigitte Van De Cotte UGent, Riet De Rycke UGent, Dominique Eeckhout UGent, Hillel Fromm, Geert De Jaeger UGent, Erwin Witters, Gerrit Beemster UGent, Dirk Inzé UGent, et al. (2007) PLANT JOURNAL. 52(5). p.850-864
abstract
The Arabidopsis thaliana genome expresses five evolutionarily conserved prohibitin (PHB) genes that are divided into type-I (AtPHB3 and AtPHB4) and type-II (AtPHB1, AtPHB2 and AtPHB6) classes, based on their phylogenetic relationships with yeast PHB1 and PHB2, respectively. Yeast and animal PHBs are reported to have diverse roles in the cell cycle, mitochondrial electron transport, aging and apoptosis. All transcribed Arabidopsis PHB genes are primarily expressed in both shoot and root proliferative tissues, where they are present in mitochondrial multimeric complexes. Loss of function of the type-I AtPHB4 had no phenotypic effects, while loss of function of the homologous AtPHB3 caused mitochondrial swelling, decreased meristematic cell production, increased cell division time and reduced cell expansion rates, leading to severe growth retardation. Double knockout atphb3 atphb4 plants were not viable, but transgenic lines overexpressing AtPHB3 or AtPHB4 showed leaf shape aberrations and an increased shoot branching phenotype. Genome-wide microarray analysis revealed that both knockout and overexpression perturbations of AtPHB3 and AtPHB4 provoked an altered abundance of mitochondrial and stress-related transcripts. We propose that plant type-I PHBs take part in protein complexes that are necessary for proficient mitochondrial function or biogenesis, thereby supporting cell division and differentiation in apical tissues.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
IDENTIFICATION, TARGET, PLANTS, GROWTH, PROMOTER, GENES, EXPRESSION, PROTEIN, CELL-DIVISION, LATERAL ROOT INITIATION, cell division, development, mitochondria, Arabidopsis, prohibitins
journal title
PLANT JOURNAL
Plant J.
volume
52
issue
5
pages
850 - 864
Web of Science type
Article
Web of Science id
000251207400006
JCR category
PLANT SCIENCES
JCR impact factor
6.751 (2007)
JCR rank
6/149 (2007)
JCR quartile
1 (2007)
ISSN
0960-7412
DOI
10.1111/j.1365-313X.2007.03276.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
414459
handle
http://hdl.handle.net/1854/LU-414459
date created
2008-05-14 17:09:00
date last changed
2016-12-19 15:43:29
@article{414459,
  abstract     = {The Arabidopsis thaliana genome expresses five evolutionarily conserved prohibitin (PHB) genes that are divided into type-I (AtPHB3 and AtPHB4) and type-II (AtPHB1, AtPHB2 and AtPHB6) classes, based on their phylogenetic relationships with yeast PHB1 and PHB2, respectively. Yeast and animal PHBs are reported to have diverse roles in the cell cycle, mitochondrial electron transport, aging and apoptosis. All transcribed Arabidopsis PHB genes are primarily expressed in both shoot and root proliferative tissues, where they are present in mitochondrial multimeric complexes. Loss of function of the type-I AtPHB4 had no phenotypic effects, while loss of function of the homologous AtPHB3 caused mitochondrial swelling, decreased meristematic cell production, increased cell division time and reduced cell expansion rates, leading to severe growth retardation. Double knockout atphb3 atphb4 plants were not viable, but transgenic lines overexpressing AtPHB3 or AtPHB4 showed leaf shape aberrations and an increased shoot branching phenotype. Genome-wide microarray analysis revealed that both knockout and overexpression perturbations of AtPHB3 and AtPHB4 provoked an altered abundance of mitochondrial and stress-related transcripts. We propose that plant type-I PHBs take part in protein complexes that are necessary for proficient mitochondrial function or biogenesis, thereby supporting cell division and differentiation in apical tissues.},
  author       = {Van Aken, Olivier and Pecenkova, Tamara and Van De Cotte, Brigitte and De Rycke, Riet and Eeckhout, Dominique and Fromm, Hillel and De Jaeger, Geert and Witters, Erwin and Beemster, Gerrit and Inz{\'e}, Dirk and Van Breusegem, Frank},
  issn         = {0960-7412},
  journal      = {PLANT JOURNAL},
  keyword      = {IDENTIFICATION,TARGET,PLANTS,GROWTH,PROMOTER,GENES,EXPRESSION,PROTEIN,CELL-DIVISION,LATERAL ROOT INITIATION,cell division,development,mitochondria,Arabidopsis,prohibitins},
  language     = {eng},
  number       = {5},
  pages        = {850--864},
  title        = {Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting proficient meristem development},
  url          = {http://dx.doi.org/10.1111/j.1365-313X.2007.03276.x},
  volume       = {52},
  year         = {2007},
}

Chicago
Van Aken, Olivier, Tamara Pecenkova, Brigitte Van De Cotte, Riet De Rycke, Dominique Eeckhout, Hillel Fromm, Geert De Jaeger, et al. 2007. “Mitochondrial type-I Prohibitins of Arabidopsis Thaliana Are Required for Supporting Proficient Meristem Development.” Plant Journal 52 (5): 850–864.
APA
Van Aken, O., Pecenkova, T., Van De Cotte, B., De Rycke, R., Eeckhout, D., Fromm, H., De Jaeger, G., et al. (2007). Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting proficient meristem development. PLANT JOURNAL, 52(5), 850–864.
Vancouver
1.
Van Aken O, Pecenkova T, Van De Cotte B, De Rycke R, Eeckhout D, Fromm H, et al. Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting proficient meristem development. PLANT JOURNAL. 2007;52(5):850–64.
MLA
Van Aken, Olivier, Tamara Pecenkova, Brigitte Van De Cotte, et al. “Mitochondrial type-I Prohibitins of Arabidopsis Thaliana Are Required for Supporting Proficient Meristem Development.” PLANT JOURNAL 52.5 (2007): 850–864. Print.