Exergetic sustainability assessment of batch versus continuous wet granulation based pharmaceutical tablet manufacturing : a cohesive analysis at three different levels
- Author
- Wouter De Soete (UGent) , Jo Dewulf (UGent) , Philippe Cappuyns, Geert Van der Vorst (UGent) , Bert Heirman, Wim Aelterman, Kris Schoeters and Herman Van Langenhove (UGent)
- Organization
- Abstract
- Identifying better performing Active Pharmaceutical Ingredient (API) synthesis routes with reference to green chemistry and green engineering principles was of the highest importance in the pharmaceutical industry during the past decade. However, very little attention was paid to other life cycle stages such as the Drug Product (DP) production, packaging and distribution. In this case, the environmental sustainability of batch versus continuous granulation based tablet manufacturing is quantified from a resource point of view by conducting Exergy Analysis (EA) and Exergetic Life Cycle Analysis (ELCA) at three different levels in order to identify and locate resource losses throughout the pharmaceutical supply chain. Assessing the potential implementation of the continuous production line ConsiGma™ at the Janssen-Cilag SpA pharmaceutical manufacturing plant and thereby replacing the conventional batch manufacturing mode would result in a resource consumption reduction of 10.2% (65.6 to 58.9 kJex per tablet), 15.2% (111 to 94.0 kJex per tablet) and 2.2% (2.3 to 2.2 MJex per tablet) at the process (α), plant (β) and overall industrial level (γ) respectively. Focusing on DP production processes by excluding transiting exergy in API, excipients and packaging materials resulted in a reduction of 34.0%, 25.9% and 14.7% at the respective system boundaries. The API dose seemed to be the parameter with highest sensitivity towards environmental burden. From an emission point of view, a Carbon Footprint (CF) reduction of 2.0% (0.22 to 0.21 kg CO2-eq per tablet) was obtained at the γ level in shifting from batch to continuous manufacturing of Tramacet®. Focusing on DP production revealed a CF reduction of 16.2%.
- Keywords
- RESOURCE CONSUMPTION, LIFE-CYCLE ASSESSMENT, TECHNOLOGY, INDUSTRY, ENERGY, TOOL, LCA
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-4143956
- MLA
- De Soete, Wouter, et al. “Exergetic Sustainability Assessment of Batch versus Continuous Wet Granulation Based Pharmaceutical Tablet Manufacturing : A Cohesive Analysis at Three Different Levels.” GREEN CHEMISTRY, vol. 15, no. 11, 2013, pp. 3039–48, doi:10.1039/C3GC41185K.
- APA
- De Soete, W., Dewulf, J., Cappuyns, P., Van der Vorst, G., Heirman, B., Aelterman, W., … Van Langenhove, H. (2013). Exergetic sustainability assessment of batch versus continuous wet granulation based pharmaceutical tablet manufacturing : a cohesive analysis at three different levels. GREEN CHEMISTRY, 15(11), 3039–3048. https://doi.org/10.1039/C3GC41185K
- Chicago author-date
- De Soete, Wouter, Jo Dewulf, Philippe Cappuyns, Geert Van der Vorst, Bert Heirman, Wim Aelterman, Kris Schoeters, and Herman Van Langenhove. 2013. “Exergetic Sustainability Assessment of Batch versus Continuous Wet Granulation Based Pharmaceutical Tablet Manufacturing : A Cohesive Analysis at Three Different Levels.” GREEN CHEMISTRY 15 (11): 3039–48. https://doi.org/10.1039/C3GC41185K.
- Chicago author-date (all authors)
- De Soete, Wouter, Jo Dewulf, Philippe Cappuyns, Geert Van der Vorst, Bert Heirman, Wim Aelterman, Kris Schoeters, and Herman Van Langenhove. 2013. “Exergetic Sustainability Assessment of Batch versus Continuous Wet Granulation Based Pharmaceutical Tablet Manufacturing : A Cohesive Analysis at Three Different Levels.” GREEN CHEMISTRY 15 (11): 3039–3048. doi:10.1039/C3GC41185K.
- Vancouver
- 1.De Soete W, Dewulf J, Cappuyns P, Van der Vorst G, Heirman B, Aelterman W, et al. Exergetic sustainability assessment of batch versus continuous wet granulation based pharmaceutical tablet manufacturing : a cohesive analysis at three different levels. GREEN CHEMISTRY. 2013;15(11):3039–48.
- IEEE
- [1]W. De Soete et al., “Exergetic sustainability assessment of batch versus continuous wet granulation based pharmaceutical tablet manufacturing : a cohesive analysis at three different levels,” GREEN CHEMISTRY, vol. 15, no. 11, pp. 3039–3048, 2013.
@article{4143956, abstract = {{Identifying better performing Active Pharmaceutical Ingredient (API) synthesis routes with reference to green chemistry and green engineering principles was of the highest importance in the pharmaceutical industry during the past decade. However, very little attention was paid to other life cycle stages such as the Drug Product (DP) production, packaging and distribution. In this case, the environmental sustainability of batch versus continuous granulation based tablet manufacturing is quantified from a resource point of view by conducting Exergy Analysis (EA) and Exergetic Life Cycle Analysis (ELCA) at three different levels in order to identify and locate resource losses throughout the pharmaceutical supply chain. Assessing the potential implementation of the continuous production line ConsiGma™ at the Janssen-Cilag SpA pharmaceutical manufacturing plant and thereby replacing the conventional batch manufacturing mode would result in a resource consumption reduction of 10.2% (65.6 to 58.9 kJex per tablet), 15.2% (111 to 94.0 kJex per tablet) and 2.2% (2.3 to 2.2 MJex per tablet) at the process (α), plant (β) and overall industrial level (γ) respectively. Focusing on DP production processes by excluding transiting exergy in API, excipients and packaging materials resulted in a reduction of 34.0%, 25.9% and 14.7% at the respective system boundaries. The API dose seemed to be the parameter with highest sensitivity towards environmental burden. From an emission point of view, a Carbon Footprint (CF) reduction of 2.0% (0.22 to 0.21 kg CO2-eq per tablet) was obtained at the γ level in shifting from batch to continuous manufacturing of Tramacet®. Focusing on DP production revealed a CF reduction of 16.2%.}}, author = {{De Soete, Wouter and Dewulf, Jo and Cappuyns, Philippe and Van der Vorst, Geert and Heirman, Bert and Aelterman, Wim and Schoeters, Kris and Van Langenhove, Herman}}, issn = {{1463-9262}}, journal = {{GREEN CHEMISTRY}}, keywords = {{RESOURCE CONSUMPTION,LIFE-CYCLE ASSESSMENT,TECHNOLOGY,INDUSTRY,ENERGY,TOOL,LCA}}, language = {{eng}}, number = {{11}}, pages = {{3039--3048}}, title = {{Exergetic sustainability assessment of batch versus continuous wet granulation based pharmaceutical tablet manufacturing : a cohesive analysis at three different levels}}, url = {{http://doi.org/10.1039/C3GC41185K}}, volume = {{15}}, year = {{2013}}, }
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