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Partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis is related to persistent nocturnal polyuria on wet nights

(2007) JOURNAL OF UROLOGY. 178(3). p.1048-1051
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Organization
Abstract
Purpose: The anti-incontinence effect of desmopressin resides in its concentrating capacity and antidiuretic properties. We compared nighttime urine production on wet and dry nights in a highly selected study population of children with monosymptomatic nocturnal enuresis associated with proved nocturnal polyuria who responded only partially to intranasal desmopressin. Materials and Methods: We retrospectively analyzed 39 home recordings of nocturnal urine production and maximum voided volume in children 7 to 19 years old (median 8.9) with monosymptomatic nocturnal enuresis with nocturnal polyuria who had a partial response to desmopressin. Nocturnal diuresis volume and maximum voided volume were documented at baseline (14 days) and during 3 months of followup. Results: Baseline nocturnal urine output (439 +/- 39 ml) was significantly higher than the maximum voided volume (346 93 ml, p <0.01). During desmopressin treatment nocturnal urine output on wet nights (405 +/- 113 ml) differed significantly from that on dry nights (241 +/- 45 ml). During treatment nocturnal urine output on wet nights did not differ from baseline values. Conclusions: Persistence of nocturnal polyuria on wet nights in partial desmopressin responders may be related to an insufficient antidiuretic effect. In addition to poor compliance and suboptimal dosing, the poor bioavailability of intranasal desmopressin may be a pathogenic factor. Further prospective studies are needed.
Keywords
MANAGEMENT, deamino arginine vasopressin, biological availability, nocturnal enuresis, polyuria, ADOLESCENTS, FUNCTIONAL BLADDER CAPACITY

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Chicago
Raes, Ann, Jo Dehoorne, Erik Van Laecke, Piet Hoebeke, Caroline Vande Walle, PIETER VANSINTJAN, Raymond AMG Donckerwolcke, and Johan Vande Walle. 2007. “Partial Response to Intranasal Desmopressin in Children with Monosymptomatic Nocturnal Enuresis Is Related to Persistent Nocturnal Polyuria on Wet Nights.” Journal of Urology 178 (3): 1048–1051.
APA
Raes, Ann, Dehoorne, J., Van Laecke, E., Hoebeke, P., Vande Walle, C., VANSINTJAN, P., Donckerwolcke, R. A., et al. (2007). Partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis is related to persistent nocturnal polyuria on wet nights. JOURNAL OF UROLOGY, 178(3), 1048–1051.
Vancouver
1.
Raes A, Dehoorne J, Van Laecke E, Hoebeke P, Vande Walle C, VANSINTJAN P, et al. Partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis is related to persistent nocturnal polyuria on wet nights. JOURNAL OF UROLOGY. 2007;178(3):1048–51.
MLA
Raes, Ann, Jo Dehoorne, Erik Van Laecke, et al. “Partial Response to Intranasal Desmopressin in Children with Monosymptomatic Nocturnal Enuresis Is Related to Persistent Nocturnal Polyuria on Wet Nights.” JOURNAL OF UROLOGY 178.3 (2007): 1048–1051. Print.
@article{414162,
  abstract     = {Purpose: The anti-incontinence effect of desmopressin resides in its concentrating capacity and antidiuretic properties. We compared nighttime urine production on wet and dry nights in a highly selected study population of children with monosymptomatic nocturnal enuresis associated with proved nocturnal polyuria who responded only partially to intranasal desmopressin.
Materials and Methods: We retrospectively analyzed 39 home recordings of nocturnal urine production and maximum voided volume in children 7 to 19 years old (median 8.9) with monosymptomatic nocturnal enuresis with nocturnal polyuria who had a partial response to desmopressin. Nocturnal diuresis volume and maximum voided volume were documented at baseline (14 days) and during 3 months of followup.
Results: Baseline nocturnal urine output (439 +/- 39 ml) was significantly higher than the maximum voided volume (346 93 ml, p <0.01). During desmopressin treatment nocturnal urine output on wet nights (405 +/- 113 ml) differed significantly from that on dry nights (241 +/- 45 ml). During treatment nocturnal urine output on wet nights did not differ from baseline values.
Conclusions: Persistence of nocturnal polyuria on wet nights in partial desmopressin responders may be related to an insufficient antidiuretic effect. In addition to poor compliance and suboptimal dosing, the poor bioavailability of intranasal desmopressin may be a pathogenic factor. Further prospective studies are needed.},
  author       = {Raes, Ann and Dehoorne, Jo and Van Laecke, Erik and Hoebeke, Piet and Vande Walle, Caroline and VANSINTJAN, PIETER and Donckerwolcke, Raymond AMG and Vande Walle, Johan},
  issn         = {0022-5347},
  journal      = {JOURNAL OF UROLOGY},
  keywords     = {MANAGEMENT,deamino arginine vasopressin,biological availability,nocturnal enuresis,polyuria,ADOLESCENTS,FUNCTIONAL BLADDER CAPACITY},
  language     = {eng},
  number       = {3},
  pages        = {1048--1051},
  title        = {Partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis is related to persistent nocturnal polyuria on wet nights},
  url          = {http://dx.doi.org/10.1016/j.juro.2007.05.060},
  volume       = {178},
  year         = {2007},
}

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