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Electrophysiological responses from vagus nerve stimulation in rats

Lies Mollet (UGent), Robrecht Raedt (UGent), Jean Delbeke (UGent), RIEM EL TAHRY (UGent), Annelies Grimonprez (UGent), Ine Dauwe (UGent), Veerle De Herdt (UGent), Alfred Meurs (UGent), Wytse Wadman (UGent), Paul Boon (UGent), et al.
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Abstract
The mechanism of action of vagus nerve stimulation (VNS) for pharmacoresistant epilepsy is unknown and the therapeutic outcome is highly variable. We investigated stimulation-induced vagus nerve electrophysiological responses in rats using various stimulation parameters. Conduction velocity, I50, rheobase and chronaxie were calculated. We identified an early and late component corresponding to an afferent compound action potential (CAP) and a remote laryngeal motor-evoked potential (LMEP), respectively. The conduction velocity (CAP: 26.2 ± 1.4 m/s; LMEP: 32.4 ± 2.4 m/s) and I50 (CAP: 2.4 ± 0.3 mA; LMEP: 1.8±0.2 mA) were significantly different for both components, the rheobase (CAP: 140±30 μA; LMEP: 110±26 μA) and chronaxie (CAP: 66±7 μs; LMEP: 73±9 μs) were not. Using a pulse of 10 μs, the CAP saturated between 4-5 mA. Our method can be used to record VNS-induced electrophysiological responses in rats and provides an objective biomarker for electrical stimulation with various parameters in an experimental set-up. Our findings are potentially useful for clinical purposes in the sense that combination of VNS and recording of vagal nerve CAPs may help clinicians to determine the individual optimal intensity required to fully activate fast-conducting afferent fibers.
Keywords
PARAMETERS, nerve fiber type, laryngeal muscle potential, vagus nerve stimulation, CUFF ELECTRODE, PARTIAL SEIZURES, ELECTRICAL-STIMULATION, EPILEPTIC PATIENTS, LOCUS-COERULEUS, VAGAL-STIMULATION, vagus nerve recording, BRAIN, MODEL, SUPPRESSION

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Chicago
Mollet, Lies, Robrecht Raedt, Jean Delbeke, RIEM EL TAHRY, Annelies Grimonprez, Ine Dauwe, Veerle De Herdt, et al. 2013. “Electrophysiological Responses from Vagus Nerve Stimulation in Rats.” International Journal of Neural Systems 23 (6).
APA
Mollet, L., Raedt, R., Delbeke, J., EL TAHRY, R., Grimonprez, A., Dauwe, I., De Herdt, V., et al. (2013). Electrophysiological responses from vagus nerve stimulation in rats. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, 23(6).
Vancouver
1.
Mollet L, Raedt R, Delbeke J, EL TAHRY R, Grimonprez A, Dauwe I, et al. Electrophysiological responses from vagus nerve stimulation in rats. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 2013;23(6).
MLA
Mollet, Lies, Robrecht Raedt, Jean Delbeke, et al. “Electrophysiological Responses from Vagus Nerve Stimulation in Rats.” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS 23.6 (2013): n. pag. Print.
@article{4140864,
  abstract     = {The mechanism of action of vagus nerve stimulation (VNS) for pharmacoresistant epilepsy is unknown and the therapeutic outcome is highly variable. We investigated stimulation-induced vagus nerve electrophysiological responses in rats using various stimulation parameters. Conduction velocity, I50, rheobase and chronaxie were calculated. We identified an early and late component corresponding to an afferent compound action potential (CAP) and a remote laryngeal motor-evoked potential (LMEP), respectively. The conduction velocity (CAP: 26.2 {\textpm} 1.4 m/s; LMEP: 32.4 {\textpm} 2.4 m/s) and I50 (CAP: 2.4 {\textpm} 0.3 mA; LMEP: 1.8{\textpm}0.2 mA) were significantly different for both components, the rheobase (CAP: 140{\textpm}30 \ensuremath{\mu}A; LMEP: 110{\textpm}26 \ensuremath{\mu}A) and chronaxie (CAP: 66{\textpm}7 \ensuremath{\mu}s; LMEP: 73{\textpm}9 \ensuremath{\mu}s) were not. Using a pulse of 10 \ensuremath{\mu}s, the CAP saturated between 4-5 mA. Our method can be used to record VNS-induced electrophysiological responses in rats and provides an objective biomarker for electrical stimulation with various parameters in an experimental set-up. Our findings are potentially useful for clinical purposes in the sense that combination of VNS and recording of vagal nerve CAPs may help clinicians to determine the individual optimal intensity required to fully activate fast-conducting afferent fibers.},
  articleno    = {1350027},
  author       = {Mollet, Lies and Raedt, Robrecht and Delbeke, Jean and EL TAHRY, RIEM and Grimonprez, Annelies and Dauwe, Ine and De Herdt, Veerle and Meurs, Alfred and Wadman, Wytse and Boon, Paul and Vonck, Kristl},
  issn         = {0129-0657},
  journal      = {INTERNATIONAL JOURNAL OF NEURAL SYSTEMS},
  keyword      = {PARAMETERS,nerve fiber type,laryngeal muscle potential,vagus nerve stimulation,CUFF ELECTRODE,PARTIAL SEIZURES,ELECTRICAL-STIMULATION,EPILEPTIC PATIENTS,LOCUS-COERULEUS,VAGAL-STIMULATION,vagus nerve recording,BRAIN,MODEL,SUPPRESSION},
  language     = {eng},
  number       = {6},
  pages        = {12},
  title        = {Electrophysiological responses from vagus nerve stimulation in rats},
  url          = {http://dx.doi.org/10.1142/S0129065713500275},
  volume       = {23},
  year         = {2013},
}

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