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Electrophysiological responses from vagus nerve stimulation in rats

Lies Mollet, Robrecht Raedt UGent, Jean Delbeke, RIEM EL TAHRY, Annelies Grimonprez, Ine Dauwe UGent, Veerle De Herdt UGent, Alfred Meurs UGent, Wytse Wadman, Paul Boon UGent, et al. (2013) INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 23(6).
abstract
The mechanism of action of vagus nerve stimulation (VNS) for pharmacoresistant epilepsy is unknown and the therapeutic outcome is highly variable. We investigated stimulation-induced vagus nerve electrophysiological responses in rats using various stimulation parameters. Conduction velocity, I50, rheobase and chronaxie were calculated. We identified an early and late component corresponding to an afferent compound action potential (CAP) and a remote laryngeal motor-evoked potential (LMEP), respectively. The conduction velocity (CAP: 26.2 ± 1.4 m/s; LMEP: 32.4 ± 2.4 m/s) and I50 (CAP: 2.4 ± 0.3 mA; LMEP: 1.8±0.2 mA) were significantly different for both components, the rheobase (CAP: 140±30 μA; LMEP: 110±26 μA) and chronaxie (CAP: 66±7 μs; LMEP: 73±9 μs) were not. Using a pulse of 10 μs, the CAP saturated between 4-5 mA. Our method can be used to record VNS-induced electrophysiological responses in rats and provides an objective biomarker for electrical stimulation with various parameters in an experimental set-up. Our findings are potentially useful for clinical purposes in the sense that combination of VNS and recording of vagal nerve CAPs may help clinicians to determine the individual optimal intensity required to fully activate fast-conducting afferent fibers.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PARAMETERS, nerve fiber type, laryngeal muscle potential, vagus nerve stimulation, CUFF ELECTRODE, PARTIAL SEIZURES, ELECTRICAL-STIMULATION, EPILEPTIC PATIENTS, LOCUS-COERULEUS, VAGAL-STIMULATION, vagus nerve recording, BRAIN, MODEL, SUPPRESSION
journal title
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
Int. J. Neural Syst.
volume
23
issue
6
article number
1350027
pages
12 pages
Web of Science type
Article
Web of Science id
000326448400003
JCR category
COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE
JCR impact factor
6.056 (2013)
JCR rank
3/121 (2013)
JCR quartile
1 (2013)
ISSN
0129-0657
DOI
10.1142/S0129065713500275
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4140864
handle
http://hdl.handle.net/1854/LU-4140864
date created
2013-09-18 14:12:35
date last changed
2016-12-21 15:41:14
@article{4140864,
  abstract     = {The mechanism of action of vagus nerve stimulation (VNS) for pharmacoresistant epilepsy is unknown and the therapeutic outcome is highly variable. We investigated stimulation-induced vagus nerve electrophysiological responses in rats using various stimulation parameters. Conduction velocity, I50, rheobase and chronaxie were calculated. We identified an early and late component corresponding to an afferent compound action potential (CAP) and a remote laryngeal motor-evoked potential (LMEP), respectively. The conduction velocity (CAP: 26.2 {\textpm} 1.4 m/s; LMEP: 32.4 {\textpm} 2.4 m/s) and I50 (CAP: 2.4 {\textpm} 0.3 mA; LMEP: 1.8{\textpm}0.2 mA) were significantly different for both components, the rheobase (CAP: 140{\textpm}30 \ensuremath{\mu}A; LMEP: 110{\textpm}26 \ensuremath{\mu}A) and chronaxie (CAP: 66{\textpm}7 \ensuremath{\mu}s; LMEP: 73{\textpm}9 \ensuremath{\mu}s) were not. Using a pulse of 10 \ensuremath{\mu}s, the CAP saturated between 4-5 mA. Our method can be used to record VNS-induced electrophysiological responses in rats and provides an objective biomarker for electrical stimulation with various parameters in an experimental set-up. Our findings are potentially useful for clinical purposes in the sense that combination of VNS and recording of vagal nerve CAPs may help clinicians to determine the individual optimal intensity required to fully activate fast-conducting afferent fibers.},
  articleno    = {1350027},
  author       = {Mollet, Lies and Raedt, Robrecht and Delbeke, Jean and EL TAHRY, RIEM and Grimonprez, Annelies and Dauwe, Ine and De Herdt, Veerle and Meurs, Alfred and Wadman, Wytse and Boon, Paul and Vonck, Kristl},
  issn         = {0129-0657},
  journal      = {INTERNATIONAL JOURNAL OF NEURAL SYSTEMS},
  keyword      = {PARAMETERS,nerve fiber type,laryngeal muscle potential,vagus nerve stimulation,CUFF ELECTRODE,PARTIAL SEIZURES,ELECTRICAL-STIMULATION,EPILEPTIC PATIENTS,LOCUS-COERULEUS,VAGAL-STIMULATION,vagus nerve recording,BRAIN,MODEL,SUPPRESSION},
  language     = {eng},
  number       = {6},
  pages        = {12},
  title        = {Electrophysiological responses from vagus nerve stimulation in rats},
  url          = {http://dx.doi.org/10.1142/S0129065713500275},
  volume       = {23},
  year         = {2013},
}

Chicago
Mollet, Lies, Robrecht Raedt, Jean Delbeke, RIEM EL TAHRY, Annelies Grimonprez, INE DAUWE, Veerle De Herdt, et al. 2013. “Electrophysiological Responses from Vagus Nerve Stimulation in Rats.” International Journal of Neural Systems 23 (6).
APA
Mollet, L., Raedt, R., Delbeke, J., EL TAHRY, R., Grimonprez, A., DAUWE, I., De Herdt, V., et al. (2013). Electrophysiological responses from vagus nerve stimulation in rats. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS, 23(6).
Vancouver
1.
Mollet L, Raedt R, Delbeke J, EL TAHRY R, Grimonprez A, DAUWE I, et al. Electrophysiological responses from vagus nerve stimulation in rats. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 2013;23(6).
MLA
Mollet, Lies, Robrecht Raedt, Jean Delbeke, et al. “Electrophysiological Responses from Vagus Nerve Stimulation in Rats.” INTERNATIONAL JOURNAL OF NEURAL SYSTEMS 23.6 (2013): n. pag. Print.