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The apparent quorum-sensing inhibitory activity of pyrogallol is a side effect of peroxide production

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Abstract
There currently is more and more interest in the use of natural products, such as tea polyphenols, as therapeutic agents. The polyphenol compound pyrogallol has been reported before to inhibit quorum-sensing-regulated bioluminescence in Vibrio harveyi. Here, we report that the addition of 10 mg(-1) liter(-1) pyrogallol protects both brine shrimp (Artemia franciscana) and giant river prawn (Macrobrachium rosenbergii) larvae from pathogenic Vibrio harveyi, whereas the compound showed relatively low toxicity (therapeutic index of 10). We further demonstrate that the apparent quorum-sensing-disrupting activity is a side effect of the peroxide-producing activity of this compound rather than true quorum-sensing inhibition. Our results emphasize that verification of minor toxic effects by using sensitive methods and the use of appropriate controls are essential when characterizing compounds as being able to disrupt quorum sensing.
Keywords
PSEUDOMONAS-AERUGINOSA, POLYPHENOLS, EXTRACTS, VIBRIO-HARVEYI

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Chicago
Defoirdt, Tom, Pande Gde Sasmita Julyantoro, Sri Kartik Baruah, and Peter Bossier. 2013. “The Apparent Quorum-sensing Inhibitory Activity of Pyrogallol Is a Side Effect of Peroxide Production.” Antimicrobial Agents and Chemotherapy 57 (6): 2870–2873.
APA
Defoirdt, Tom, Sasmita Julyantoro, P. G., Baruah, S. K., & Bossier, P. (2013). The apparent quorum-sensing inhibitory activity of pyrogallol is a side effect of peroxide production. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(6), 2870–2873.
Vancouver
1.
Defoirdt T, Sasmita Julyantoro PG, Baruah SK, Bossier P. The apparent quorum-sensing inhibitory activity of pyrogallol is a side effect of peroxide production. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2013;57(6):2870–3.
MLA
Defoirdt, Tom, Pande Gde Sasmita Julyantoro, Sri Kartik Baruah, et al. “The Apparent Quorum-sensing Inhibitory Activity of Pyrogallol Is a Side Effect of Peroxide Production.” ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 57.6 (2013): 2870–2873. Print.
@article{4140763,
  abstract     = {There currently is more and more interest in the use of natural products, such as tea polyphenols, as therapeutic agents. The polyphenol compound pyrogallol has been reported before to inhibit quorum-sensing-regulated bioluminescence in Vibrio harveyi. Here, we report that the addition of 10 mg(-1) liter(-1) pyrogallol protects both brine shrimp (Artemia franciscana) and giant river prawn (Macrobrachium rosenbergii) larvae from pathogenic Vibrio harveyi, whereas the compound showed relatively low toxicity (therapeutic index of 10). We further demonstrate that the apparent quorum-sensing-disrupting activity is a side effect of the peroxide-producing activity of this compound rather than true quorum-sensing inhibition. Our results emphasize that verification of minor toxic effects by using sensitive methods and the use of appropriate controls are essential when characterizing compounds as being able to disrupt quorum sensing.},
  author       = {Defoirdt, Tom and Sasmita Julyantoro, Pande Gde and Baruah, Sri Kartik and Bossier, Peter},
  issn         = {0066-4804},
  journal      = {ANTIMICROBIAL AGENTS AND CHEMOTHERAPY},
  keyword      = {PSEUDOMONAS-AERUGINOSA,POLYPHENOLS,EXTRACTS,VIBRIO-HARVEYI},
  language     = {eng},
  number       = {6},
  pages        = {2870--2873},
  title        = {The apparent quorum-sensing inhibitory activity of pyrogallol is a side effect of peroxide production},
  url          = {http://dx.doi.org/10.1128/AAC.00401-13},
  volume       = {57},
  year         = {2013},
}

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