Advanced search

Lack of evidence of hypervolemia in children with insulin-dependent diabetes mellitus

(2007) PEDIATRIC NEPHROLOGY. 22(2). p.258-264
Author
Organization
Abstract
Hypervolemia is considered to play a major role in the pathogenesis of diabetic vasculo- and nephropathy. The aim of our study is to determine whether children and adolescents with insulin-dependent diabetes mellitus (IDDM) experience alterations in blood volume (BV) before onset of apparent nephropathy. BV (calculated as the sum of measured plasma volume (PV) and red cell volume (RCV)) was determined in 31 children (9-16 yr) with a mean duration of IDDM of 6.6 yr and without microalbuminuria. Due to dependence of these values on age, size and sex, all data were normalised for body size parameters. While no statistical difference for BV normalised for lean body mass (LBM) (86.98 +/- 9.5 ml/kg) was found in diabetic children compared with our control population (84.91 +/- 12.08 ml/kg), a difference could be shown when normalised for body surface area (BSA) (diabetic children 2.37 +/- 0.3 L/m(2); control population 2.15 +/- 0.38 L/m(2), p=0.002). Increased BV is only present when normalising for BSA and not for the theoretical superior LBM-index. Because the study population exhibited a poor glycemic control (HbAlc 10.2 +/- 2.4%), an influence of glucosuria-induced polyuria on BV cannot be excluded. Taking into account these limitations our data do not confirm the presence of hypervolemia before onset of diabetic nephropathy.
Keywords
insulin-dependent diabetes mellitus, blood volume, lean body mass, body surface area, F-cell ratio, BLOOD-PRESSURE, FLUID VOLUMES, SODIUM, RENIN, CATECHOLAMINES, ANGIOTENSIN, ALDOSTERONE, WEIGHT, HEIGHT, PLASMA

Citation

Please use this url to cite or link to this publication:

Chicago
Raes, Ann, Sara Van Aken, Margarita Craen, Raymond AMG Donckerwolcke, and Johan Vande Walle. 2007. “Lack of Evidence of Hypervolemia in Children with Insulin-dependent Diabetes Mellitus.” Pediatric Nephrology 22 (2): 258–264.
APA
Raes, A., Van Aken, S., Craen, M., Donckerwolcke, R. A., & Vande Walle, J. (2007). Lack of evidence of hypervolemia in children with insulin-dependent diabetes mellitus. PEDIATRIC NEPHROLOGY, 22(2), 258–264.
Vancouver
1.
Raes A, Van Aken S, Craen M, Donckerwolcke RA, Vande Walle J. Lack of evidence of hypervolemia in children with insulin-dependent diabetes mellitus. PEDIATRIC NEPHROLOGY. 2007;22(2):258–64.
MLA
Raes, Ann et al. “Lack of Evidence of Hypervolemia in Children with Insulin-dependent Diabetes Mellitus.” PEDIATRIC NEPHROLOGY 22.2 (2007): 258–264. Print.
@article{413681,
  abstract     = {Hypervolemia is considered to play a major role in the pathogenesis of diabetic vasculo- and nephropathy. The aim of our study is to determine whether children and adolescents with insulin-dependent diabetes mellitus (IDDM) experience alterations in blood volume (BV) before onset of apparent nephropathy. BV (calculated as the sum of measured plasma volume (PV) and red cell volume (RCV)) was determined in 31 children (9-16 yr) with a mean duration of IDDM of 6.6 yr and without microalbuminuria. Due to dependence of these values on age, size and sex, all data were normalised for body size parameters. While no statistical difference for BV normalised for lean body mass (LBM) (86.98 +/- 9.5 ml/kg) was found in diabetic children compared with our control population (84.91 +/- 12.08 ml/kg), a difference could be shown when normalised for body surface area (BSA) (diabetic children 2.37 +/- 0.3 L/m(2); control population 2.15 +/- 0.38 L/m(2), p=0.002). Increased BV is only present when normalising for BSA and not for the theoretical superior LBM-index. Because the study population exhibited a poor glycemic control (HbAlc 10.2 +/- 2.4\%), an influence of glucosuria-induced polyuria on BV cannot be excluded. Taking into account these limitations our data do not confirm the presence of hypervolemia before onset of diabetic nephropathy.},
  author       = {Raes, Ann and Van Aken, Sara and Craen, Margarita and Donckerwolcke, Raymond AMG and Vande Walle, Johan},
  issn         = {0931-041X},
  journal      = {PEDIATRIC NEPHROLOGY},
  language     = {eng},
  number       = {2},
  pages        = {258--264},
  title        = {Lack of evidence of hypervolemia in children with insulin-dependent diabetes mellitus},
  url          = {http://dx.doi.org/10.1007/s00467-006-0258-4},
  volume       = {22},
  year         = {2007},
}

Altmetric
View in Altmetric
Web of Science
Times cited: