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Genome wide measurement of DNA copy number changes in neuroblastoma: dissecting amplicons and mapping losses, gains and breakpoints

Evi Michels UGent, Jo Vandesompele UGent, Jasmien Hoebeeck UGent, Björn Menten UGent, Katleen De Preter UGent, Genevieve Laureys UGent, Nadine Van Roy UGent and Franki Speleman UGent (2006) CYTOGENETIC AND GENOME RESEARCH. 115(3-4). p.273-282
abstract
In the past few years high throughput methods for assessment of DNA copy number alterations have witnessed rapid progress. Both 'in house' developed BAC, cDNA, oligonucleotide and commercial arrays are now available and widely applied in the study of the human genome, particularly in the context of disease. Cancer cells are known to exhibit DNA losses, gains and amplifications affecting tumor suppressor genes and proto-oncogenes. Moreover, these patterns of genomic imbalances may be associated with particular tumor types or subtypes and may have prognostic value. Here we summarize recent array CGH findings in neuroblastoma, a pediatric tumor of the sympathetic nervous system. A total of 176 primary tumors and 53 cell lines have been analyzed on different platforms. Through these studies the genomic content and boundaries of deletions, gains and amplifications were characterized with unprecedented accuracy. Furthermore, in conjunction with cytogenetic findings, array CGH allows the mapping of breakpoints of unbalanced translocations at a very high resolution.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
HYBRIDIZATION CGH ANALYSIS, HIGH-RESOLUTION ANALYSIS, ACUTE MYELOID LEUKEMIAS, TUMOR-SUPPRESSOR GENE, HUMAN NEURO-BLASTOMA, COMMON ALLELIC LOSS, CELL-LINES, ARRAY-CGH, N-MYC, CYTOGENETIC ANALYSIS
journal title
CYTOGENETIC AND GENOME RESEARCH
Cytogenet. Genome Res.
volume
115
issue
3-4
pages
273 - 282
Web of Science type
Article
Web of Science id
000242391500011
JCR category
GENETICS & HEREDITY
JCR impact factor
1.993 (2006)
JCR rank
83/128 (2006)
JCR quartile
3 (2006)
ISSN
1424-8581
DOI
10.1159/000095924
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
413438
handle
http://hdl.handle.net/1854/LU-413438
date created
2007-03-30 13:21:00
date last changed
2016-12-19 15:42:25
@article{413438,
  abstract     = {In the past few years high throughput methods for assessment of DNA copy number alterations have witnessed rapid progress. Both 'in house' developed BAC, cDNA, oligonucleotide and commercial arrays are now available and widely applied in the study of the human genome, particularly in the context of disease. Cancer cells are known to exhibit DNA losses, gains and amplifications affecting tumor suppressor genes and proto-oncogenes. Moreover, these patterns of genomic imbalances may be associated with particular tumor types or subtypes and may have prognostic value. Here we summarize recent array CGH findings in neuroblastoma, a pediatric tumor of the sympathetic nervous system. A total of 176 primary tumors and 53 cell lines have been analyzed on different platforms. Through these studies the genomic content and boundaries of deletions, gains and amplifications were characterized with unprecedented accuracy. Furthermore, in conjunction with cytogenetic findings, array CGH allows the mapping of breakpoints of unbalanced translocations at a very high resolution.},
  author       = {Michels, Evi and Vandesompele, Jo and Hoebeeck, Jasmien and Menten, Bj{\"o}rn and De Preter, Katleen and Laureys, Genevieve and Van Roy, Nadine and Speleman, Franki},
  issn         = {1424-8581},
  journal      = {CYTOGENETIC AND GENOME RESEARCH},
  keyword      = {HYBRIDIZATION CGH ANALYSIS,HIGH-RESOLUTION ANALYSIS,ACUTE MYELOID LEUKEMIAS,TUMOR-SUPPRESSOR GENE,HUMAN NEURO-BLASTOMA,COMMON ALLELIC LOSS,CELL-LINES,ARRAY-CGH,N-MYC,CYTOGENETIC ANALYSIS},
  language     = {eng},
  number       = {3-4},
  pages        = {273--282},
  title        = {Genome wide measurement of DNA copy number changes in neuroblastoma: dissecting amplicons and mapping losses, gains and breakpoints},
  url          = {http://dx.doi.org/10.1159/000095924},
  volume       = {115},
  year         = {2006},
}

Chicago
Michels, Evi, Jo Vandesompele, Jasmien Hoebeeck, Björn Menten, Katleen De Preter, Genevieve Laureys, Nadine Van Roy, and Franki Speleman. 2006. “Genome Wide Measurement of DNA Copy Number Changes in Neuroblastoma: Dissecting Amplicons and Mapping Losses, Gains and Breakpoints.” Cytogenetic and Genome Research 115 (3-4): 273–282.
APA
Michels, E., Vandesompele, J., Hoebeeck, J., Menten, B., De Preter, K., Laureys, G., Van Roy, N., et al. (2006). Genome wide measurement of DNA copy number changes in neuroblastoma: dissecting amplicons and mapping losses, gains and breakpoints. CYTOGENETIC AND GENOME RESEARCH, 115(3-4), 273–282.
Vancouver
1.
Michels E, Vandesompele J, Hoebeeck J, Menten B, De Preter K, Laureys G, et al. Genome wide measurement of DNA copy number changes in neuroblastoma: dissecting amplicons and mapping losses, gains and breakpoints. CYTOGENETIC AND GENOME RESEARCH. 2006;115(3-4):273–82.
MLA
Michels, Evi, Jo Vandesompele, Jasmien Hoebeeck, et al. “Genome Wide Measurement of DNA Copy Number Changes in Neuroblastoma: Dissecting Amplicons and Mapping Losses, Gains and Breakpoints.” CYTOGENETIC AND GENOME RESEARCH 115.3-4 (2006): 273–282. Print.