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Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins

Claudina Perez Novo, Cindy Claeys, Thibaut Van Zele UGent, Gabriële Holtappels UGent, Paul Van Cauwenberge and Claus Bachert UGent (2006) AMERICAN JOURNAL OF RHINOLOGY. 20(4). p.456-460
abstract
Background: Staphylococcus aureus-derived enterotoxins (SEs) have been implicated in the pathogenesis of airway inflammatory diseases, especially nasal polyposis. However, the exact role of these molecules in the regulation of eicosanoid synthesis in this pathology remains unexplored. We studied the possible impact of SE-induced immune responses on the eicosanloid production in nasal polyp (NP) patients. Methods: Tissue sample homogenates from NP patients, with (NP-SEs[+]) and without detectable IgE-antibodies to SEs (NP-SEs[-]; ImmunoCap system), were assayed for IL-5, myeloperoxidase, leukotriene C-4/D-4/E-4, (LTC4/D-4/E-4), LTB4, lipoxin A(4), total IgE, and eosinophil calionic protein. Results: Inflammatory makers, eicosanoids, and total IgE were significantly increased in NP-SEs(+) compared with NP-SEs(-) tissues, with the exception of myeloperoxidase, which was similar in both groups. Eicosanoid concentrations correlated to IL-5 and eosinophil cationic protein; however, only cys-leukotriene levels correlated with IgE-antibodies to SEs, independently of allergy and asthma. Conclusion: Eicosanoid synthesis is up-regulated in polyp tissue of patients with immune response to SEs and seems to be related to the inflammatory reaction induced by these enterotoxins.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ASTHMA, IMMUNOGLOBULIN-E, CELLS, MICE, LEUKOTRIENE, EXPRESSION, SUPERANTIGEN, INTERLEUKIN-4, IGE, MEDIATOR
journal title
AMERICAN JOURNAL OF RHINOLOGY
Am. J. Rhinol.
volume
20
issue
4
pages
456 - 460
Web of Science type
Article
Web of Science id
000240047200018
JCR category
OTORHINOLARYNGOLOGY
JCR impact factor
1.22 (2006)
JCR rank
10/30 (2006)
JCR quartile
2 (2006)
ISSN
1050-6586
DOI
10.2500/ajr.2006.20.2873
language
English
UGent publication?
yes
classification
A1
id
413262
handle
http://hdl.handle.net/1854/LU-413262
date created
2007-03-07 15:23:00
date last changed
2016-12-19 15:42:25
@article{413262,
  abstract     = {Background: Staphylococcus aureus-derived enterotoxins (SEs) have been implicated in the pathogenesis of airway inflammatory diseases, especially nasal polyposis. However, the exact role of these molecules in the regulation of eicosanoid synthesis in this pathology remains unexplored. We studied the possible impact of SE-induced immune responses on the eicosanloid production in nasal polyp (NP) patients.
Methods: Tissue sample homogenates from NP patients, with (NP-SEs[+]) and without detectable IgE-antibodies to SEs (NP-SEs[-]; ImmunoCap system), were assayed for IL-5, myeloperoxidase, leukotriene C-4/D-4/E-4, (LTC4/D-4/E-4), LTB4, lipoxin A(4), total IgE, and eosinophil calionic protein.
Results: Inflammatory makers, eicosanoids, and total IgE were significantly increased in NP-SEs(+) compared with NP-SEs(-) tissues, with the exception of myeloperoxidase, which was similar in both groups. Eicosanoid concentrations correlated to IL-5 and eosinophil cationic protein; however, only cys-leukotriene levels correlated with IgE-antibodies to SEs, independently of allergy and asthma.
Conclusion: Eicosanoid synthesis is up-regulated in polyp tissue of patients with immune response to SEs and seems to be related to the inflammatory reaction induced by these enterotoxins.},
  author       = {Perez Novo, Claudina and Claeys, Cindy and Van Zele, Thibaut and Holtappels, Gabri{\"e}le and Van Cauwenberge, Paul and Bachert, Claus},
  issn         = {1050-6586},
  journal      = {AMERICAN JOURNAL OF RHINOLOGY},
  keyword      = {ASTHMA,IMMUNOGLOBULIN-E,CELLS,MICE,LEUKOTRIENE,EXPRESSION,SUPERANTIGEN,INTERLEUKIN-4,IGE,MEDIATOR},
  language     = {eng},
  number       = {4},
  pages        = {456--460},
  title        = {Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins},
  url          = {http://dx.doi.org/10.2500/ajr.2006.20.2873},
  volume       = {20},
  year         = {2006},
}

Chicago
Perez Novo, Claudina, Cindy Claeys, Thibaut Van Zele, Gabriële Holtappels, Paul Van Cauwenberge, and Claus Bachert. 2006. “Eicosanoid Metabolism and Eosinophilic Inflammation in Nasal Polyp Patients with Immune Response to Staphylococcus Aureus Enterotoxins.” American Journal of Rhinology 20 (4): 456–460.
APA
Perez Novo, C., Claeys, C., Van Zele, T., Holtappels, G., Van Cauwenberge, P., & Bachert, C. (2006). Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins. AMERICAN JOURNAL OF RHINOLOGY, 20(4), 456–460.
Vancouver
1.
Perez Novo C, Claeys C, Van Zele T, Holtappels G, Van Cauwenberge P, Bachert C. Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins. AMERICAN JOURNAL OF RHINOLOGY. 2006;20(4):456–60.
MLA
Perez Novo, Claudina, Cindy Claeys, Thibaut Van Zele, et al. “Eicosanoid Metabolism and Eosinophilic Inflammation in Nasal Polyp Patients with Immune Response to Staphylococcus Aureus Enterotoxins.” AMERICAN JOURNAL OF RHINOLOGY 20.4 (2006): 456–460. Print.