Advanced search
1 file | 828.16 KB

Electrical brain imaging reveals the expression and timing of altered error monitoring functions in major depression

(2013) JOURNAL OF ABNORMAL PSYCHOLOGY. 122(4). p.939-950
Author
Organization
Project
The integrative neuroscience of behavioral control (Neuroscience)
Project
The integrative neuroscience of behavioral control (Neuroscience)
Abstract
Major depressive disorder (MDD) is characterized by disturbances in affect, motivation, and cognitive control processes, including error detection. However, the expression and timing of the impairments during error monitoring remain unclear in MDD. The behavior and event-related brain responses (ERPs) of 20 patients with MDD were compared with those of 20 healthy controls (HCs), while they performed a Go/noGo task. Errors during this task were associated with 2 ERP components, the error-related negativity (ERN/Ne) and the error positivity (Pe). Results show that the ERN/Ne-correct-related negativity (CRN) amplitude difference was significantly larger in MDD patients (after controlling for speed), compared with HCs, although MDD patients exhibited overactive medial frontal cortex (MFC) activation. By comparison, the subsequent Pe component was smaller in MDD patients compared with HCs and this effect was accompanied by a reduced activation of ventral anterior cingulate cortex (ACC) regions. These results suggest that MDD has multiple cascade effects on early error monitoring brain mechanisms.
Keywords
SPATIOTEMPORAL DYNAMICS, EVENT-RELATED POTENTIALS, COGNITIVE CONTROL, CINGULATE CORTEX, RESPONSE ERRORS, NEGATIVITY ERN, NEURAL SYSTEM, TIME-COURSE, DISORDER, COMPONENTS, major depression, action-monitoring, error-related negativity (ERN), error positivity (Pe)

Downloads

  • Aarts Vanderhasselt JoAP.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 828.16 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Aarts, Kristien, Marie-Anne Vanderhasselt, Georges Otte, Chris Baeken, and Gilles Pourtois. 2013. “Electrical Brain Imaging Reveals the Expression and Timing of Altered Error Monitoring Functions in Major Depression.” Journal of Abnormal Psychology 122 (4): 939–950.
APA
Aarts, K., Vanderhasselt, M.-A., Otte, G., Baeken, C., & Pourtois, G. (2013). Electrical brain imaging reveals the expression and timing of altered error monitoring functions in major depression. JOURNAL OF ABNORMAL PSYCHOLOGY, 122(4), 939–950.
Vancouver
1.
Aarts K, Vanderhasselt M-A, Otte G, Baeken C, Pourtois G. Electrical brain imaging reveals the expression and timing of altered error monitoring functions in major depression. JOURNAL OF ABNORMAL PSYCHOLOGY. 2013;122(4):939–50.
MLA
Aarts, Kristien et al. “Electrical Brain Imaging Reveals the Expression and Timing of Altered Error Monitoring Functions in Major Depression.” JOURNAL OF ABNORMAL PSYCHOLOGY 122.4 (2013): 939–950. Print.
@article{4131236,
  abstract     = {Major depressive disorder (MDD) is characterized by disturbances in affect, motivation, and cognitive control processes, including error detection. However, the expression and timing of the impairments during error monitoring remain unclear in MDD. The behavior and event-related brain responses (ERPs) of 20 patients with MDD were compared with those of 20 healthy controls (HCs), while they performed a Go/noGo task. Errors during this task were associated with 2 ERP components, the error-related negativity (ERN/Ne) and the error positivity (Pe). Results show that the ERN/Ne-correct-related negativity (CRN) amplitude difference was significantly larger in MDD patients (after controlling for speed), compared with HCs, although MDD patients exhibited overactive medial frontal cortex (MFC) activation. By comparison, the subsequent Pe component was smaller in MDD patients compared with HCs and this effect was accompanied by a reduced activation of ventral anterior cingulate cortex (ACC) regions. These results suggest that MDD has multiple cascade effects on early error monitoring brain mechanisms.},
  author       = {Aarts, Kristien and Vanderhasselt, Marie-Anne and Otte, Georges and Baeken, Chris and Pourtois, Gilles},
  issn         = {0021-843X},
  journal      = {JOURNAL OF ABNORMAL PSYCHOLOGY},
  keywords     = {SPATIOTEMPORAL DYNAMICS,EVENT-RELATED POTENTIALS,COGNITIVE CONTROL,CINGULATE CORTEX,RESPONSE ERRORS,NEGATIVITY ERN,NEURAL SYSTEM,TIME-COURSE,DISORDER,COMPONENTS,major depression,action-monitoring,error-related negativity (ERN),error positivity (Pe)},
  language     = {eng},
  number       = {4},
  pages        = {939--950},
  title        = {Electrical brain imaging reveals the expression and timing of altered error monitoring functions in major depression},
  url          = {http://dx.doi.org/10.1037/a0034616},
  volume       = {122},
  year         = {2013},
}

Altmetric
View in Altmetric
Web of Science
Times cited: