The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces: a study in humans
- Author
- Elisabeth De Wilde, Ryo Jimbo, Ann Wennerberg, Yoshihito Naito, Paul Coucke (UGent) , Matthew S Bryington, Stefan Vandeweghe (UGent) and Hugo De Bruyn (UGent)
- Organization
- Abstract
- OBJECTIVE: To evaluate the soft tissue response in humans immunologically and histologically after placement of mini-implants coated with or without nano-size hydroxyapatite coatings. MATERIAL AND METHODS: Commercially pure (cp) titanium mini-implants (n = 13) or nano-hydroxyapatite-coated ones (n = 12) were randomly placed into partially edentulous jaws. Crevicular fluid was sampled 1 week after placement and subjected to quantitative polymerase chain reaction analysis to explore the inflammatory markers. After 8 weeks, implants and surrounding soft and hard tissue were trephined, and undecalcified ground sections were prepared. Inflammatory cell accumulation within a defined region of interest in the soft tissue was quantified histomorphometrically. RESULTS: No statistically significant differences in immunological response to the different implant surfaces were found for IL-6 (p = .438), TGF-β2 (p = .467), MMP-8 (p = .758), CCL-3 (p = .758), IL-8 (p = .771), and IL-1β (0.771). Histomorphometric evaluation presented no statistically significant difference between the two mini-implant surfaces with regards to number of inflammatory cells (p = .669). CONCLUSION: Nano-hydroxyapatite-coated surfaces in the transmucosal region yielded similar inflammatory response and is suggested to be as biocompatible as commercially pure titanium surfaces.
- Keywords
- human, nanotopography, gene expression, osseointegration, dental implant, hydroxyapatite, CRESTAL/MARGINAL BONE LOSS, HUMAN GINGIVAL FIBROBLASTS, DENTAL IMPLANT, PROINFLAMMATORY CYTOKINES, ATTACHMENT, DOGS, COMPLICATIONS, INTEGRATION, TOPOGRAPHY, ABUTMENTS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-4128310
- MLA
- De Wilde, Elisabeth, et al. “The Soft Tissue Immunologic Response to Hydroxyapatite-Coated Transmucosal Implant Surfaces: A Study in Humans.” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, vol. 17, no. suppl. 1, 2015, pp. e65–74, doi:10.1111/cid.12128.
- APA
- De Wilde, E., Jimbo, R., Wennerberg, A., Naito, Y., Coucke, P., Bryington, M. S., … De Bruyn, H. (2015). The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces: a study in humans. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 17(suppl. 1), e65–e74. https://doi.org/10.1111/cid.12128
- Chicago author-date
- De Wilde, Elisabeth, Ryo Jimbo, Ann Wennerberg, Yoshihito Naito, Paul Coucke, Matthew S Bryington, Stefan Vandeweghe, and Hugo De Bruyn. 2015. “The Soft Tissue Immunologic Response to Hydroxyapatite-Coated Transmucosal Implant Surfaces: A Study in Humans.” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH 17 (suppl. 1): e65–74. https://doi.org/10.1111/cid.12128.
- Chicago author-date (all authors)
- De Wilde, Elisabeth, Ryo Jimbo, Ann Wennerberg, Yoshihito Naito, Paul Coucke, Matthew S Bryington, Stefan Vandeweghe, and Hugo De Bruyn. 2015. “The Soft Tissue Immunologic Response to Hydroxyapatite-Coated Transmucosal Implant Surfaces: A Study in Humans.” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH 17 (suppl. 1): e65–e74. doi:10.1111/cid.12128.
- Vancouver
- 1.De Wilde E, Jimbo R, Wennerberg A, Naito Y, Coucke P, Bryington MS, et al. The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces: a study in humans. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH. 2015;17(suppl. 1):e65–74.
- IEEE
- [1]E. De Wilde et al., “The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces: a study in humans,” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, vol. 17, no. suppl. 1, pp. e65–e74, 2015.
@article{4128310, abstract = {{OBJECTIVE: To evaluate the soft tissue response in humans immunologically and histologically after placement of mini-implants coated with or without nano-size hydroxyapatite coatings. MATERIAL AND METHODS: Commercially pure (cp) titanium mini-implants (n = 13) or nano-hydroxyapatite-coated ones (n = 12) were randomly placed into partially edentulous jaws. Crevicular fluid was sampled 1 week after placement and subjected to quantitative polymerase chain reaction analysis to explore the inflammatory markers. After 8 weeks, implants and surrounding soft and hard tissue were trephined, and undecalcified ground sections were prepared. Inflammatory cell accumulation within a defined region of interest in the soft tissue was quantified histomorphometrically. RESULTS: No statistically significant differences in immunological response to the different implant surfaces were found for IL-6 (p = .438), TGF-β2 (p = .467), MMP-8 (p = .758), CCL-3 (p = .758), IL-8 (p = .771), and IL-1β (0.771). Histomorphometric evaluation presented no statistically significant difference between the two mini-implant surfaces with regards to number of inflammatory cells (p = .669). CONCLUSION: Nano-hydroxyapatite-coated surfaces in the transmucosal region yielded similar inflammatory response and is suggested to be as biocompatible as commercially pure titanium surfaces.}}, author = {{De Wilde, Elisabeth and Jimbo, Ryo and Wennerberg, Ann and Naito, Yoshihito and Coucke, Paul and Bryington, Matthew S and Vandeweghe, Stefan and De Bruyn, Hugo}}, issn = {{1523-0899}}, journal = {{CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH}}, keywords = {{human,nanotopography,gene expression,osseointegration,dental implant,hydroxyapatite,CRESTAL/MARGINAL BONE LOSS,HUMAN GINGIVAL FIBROBLASTS,DENTAL IMPLANT,PROINFLAMMATORY CYTOKINES,ATTACHMENT,DOGS,COMPLICATIONS,INTEGRATION,TOPOGRAPHY,ABUTMENTS}}, language = {{eng}}, number = {{suppl. 1}}, pages = {{e65--e74}}, title = {{The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces: a study in humans}}, url = {{http://doi.org/10.1111/cid.12128}}, volume = {{17}}, year = {{2015}}, }
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