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The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces: a study in humans

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Abstract
OBJECTIVE: To evaluate the soft tissue response in humans immunologically and histologically after placement of mini-implants coated with or without nano-size hydroxyapatite coatings. MATERIAL AND METHODS: Commercially pure (cp) titanium mini-implants (n = 13) or nano-hydroxyapatite-coated ones (n = 12) were randomly placed into partially edentulous jaws. Crevicular fluid was sampled 1 week after placement and subjected to quantitative polymerase chain reaction analysis to explore the inflammatory markers. After 8 weeks, implants and surrounding soft and hard tissue were trephined, and undecalcified ground sections were prepared. Inflammatory cell accumulation within a defined region of interest in the soft tissue was quantified histomorphometrically. RESULTS: No statistically significant differences in immunological response to the different implant surfaces were found for IL-6 (p = .438), TGF-β2 (p = .467), MMP-8 (p = .758), CCL-3 (p = .758), IL-8 (p = .771), and IL-1β (0.771). Histomorphometric evaluation presented no statistically significant difference between the two mini-implant surfaces with regards to number of inflammatory cells (p = .669). CONCLUSION: Nano-hydroxyapatite-coated surfaces in the transmucosal region yielded similar inflammatory response and is suggested to be as biocompatible as commercially pure titanium surfaces.
Keywords
human, nanotopography, gene expression, osseointegration, dental implant, hydroxyapatite, CRESTAL/MARGINAL BONE LOSS, HUMAN GINGIVAL FIBROBLASTS, DENTAL IMPLANT, PROINFLAMMATORY CYTOKINES, ATTACHMENT, DOGS, COMPLICATIONS, INTEGRATION, TOPOGRAPHY, ABUTMENTS

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MLA
De Wilde, Elisabeth, et al. “The Soft Tissue Immunologic Response to Hydroxyapatite-Coated Transmucosal Implant Surfaces: A Study in Humans.” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, vol. 17, no. suppl. 1, 2015, pp. e65–74, doi:10.1111/cid.12128.
APA
De Wilde, E., Jimbo, R., Wennerberg, A., Naito, Y., Coucke, P., Bryington, M. S., … De Bruyn, H. (2015). The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces: a study in humans. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 17(suppl. 1), e65–e74. https://doi.org/10.1111/cid.12128
Chicago author-date
De Wilde, Elisabeth, Ryo Jimbo, Ann Wennerberg, Yoshihito Naito, Paul Coucke, Matthew S Bryington, Stefan Vandeweghe, and Hugo De Bruyn. 2015. “The Soft Tissue Immunologic Response to Hydroxyapatite-Coated Transmucosal Implant Surfaces: A Study in Humans.” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH 17 (suppl. 1): e65–74. https://doi.org/10.1111/cid.12128.
Chicago author-date (all authors)
De Wilde, Elisabeth, Ryo Jimbo, Ann Wennerberg, Yoshihito Naito, Paul Coucke, Matthew S Bryington, Stefan Vandeweghe, and Hugo De Bruyn. 2015. “The Soft Tissue Immunologic Response to Hydroxyapatite-Coated Transmucosal Implant Surfaces: A Study in Humans.” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH 17 (suppl. 1): e65–e74. doi:10.1111/cid.12128.
Vancouver
1.
De Wilde E, Jimbo R, Wennerberg A, Naito Y, Coucke P, Bryington MS, et al. The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces: a study in humans. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH. 2015;17(suppl. 1):e65–74.
IEEE
[1]
E. De Wilde et al., “The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces: a study in humans,” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, vol. 17, no. suppl. 1, pp. e65–e74, 2015.
@article{4128310,
  abstract     = {{OBJECTIVE: To evaluate the soft tissue response in humans immunologically and histologically after placement of mini-implants coated with or without nano-size hydroxyapatite coatings.
MATERIAL AND METHODS: Commercially pure (cp) titanium mini-implants (n = 13) or nano-hydroxyapatite-coated ones (n = 12) were randomly placed into partially edentulous jaws. Crevicular fluid was sampled 1 week after placement and subjected to quantitative polymerase chain reaction analysis to explore the inflammatory markers. After 8 weeks, implants and surrounding soft and hard tissue were trephined, and undecalcified ground sections were prepared. Inflammatory cell accumulation within a defined region of interest in the soft tissue was quantified histomorphometrically.
RESULTS: No statistically significant differences in immunological response to the different implant surfaces were found for IL-6 (p = .438), TGF-β2 (p = .467), MMP-8 (p = .758), CCL-3 (p = .758), IL-8 (p = .771), and IL-1β (0.771). Histomorphometric evaluation presented no statistically significant difference between the two mini-implant surfaces with regards to number of inflammatory cells (p = .669).
CONCLUSION: Nano-hydroxyapatite-coated surfaces in the transmucosal region yielded similar inflammatory response and is suggested to be as biocompatible as commercially pure titanium surfaces.}},
  author       = {{De Wilde, Elisabeth and Jimbo, Ryo and Wennerberg, Ann and Naito, Yoshihito and Coucke, Paul and Bryington, Matthew S and Vandeweghe, Stefan and De Bruyn, Hugo}},
  issn         = {{1523-0899}},
  journal      = {{CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH}},
  keywords     = {{human,nanotopography,gene expression,osseointegration,dental implant,hydroxyapatite,CRESTAL/MARGINAL BONE LOSS,HUMAN GINGIVAL FIBROBLASTS,DENTAL IMPLANT,PROINFLAMMATORY CYTOKINES,ATTACHMENT,DOGS,COMPLICATIONS,INTEGRATION,TOPOGRAPHY,ABUTMENTS}},
  language     = {{eng}},
  number       = {{suppl. 1}},
  pages        = {{e65--e74}},
  title        = {{The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces: a study in humans}},
  url          = {{http://doi.org/10.1111/cid.12128}},
  volume       = {{17}},
  year         = {{2015}},
}

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