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The role of lung dendritic cell subsets in immunity to respiratory viruses

Katrijn Neyt (UGent) and Bart Lambrecht (UGent)
(2013) IMMUNOLOGICAL REVIEWS. 255(1). p.57-67
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Abstract
Viral infections are a common cause of acute respiratory disease. The clinical course of infection and symptoms depend on the viral strain, the health status of the host, and the immunological status of the host. Dendritic cells (DCs) play a crucial role in recognizing and presenting viral antigens and in inducing adaptive immune responses that clear the virus. Because the lung is continuously exposed to the air, the lung is equipped with an elaborate network of DCs to sense incoming foreign pathogens. Increasing knowledge on DC biology has informed us that DCs are not a single cell type. In the steady state lung, three DC subsets can be defined: CD11b(+) or CD103(+) conventional DCs and plasmacytoid DCs. Upon inflammation, inflammatory monocyte-derived DCs are recruited to the lung. It is only recently that tools became available to allow DC subsets to be clearly studied. This review focuses on the activation of DCs and the function of lung DCs in the context of respiratory virus infection and highlights some cautionary points for interpreting older experiments.
Keywords
lung, CD8(+) T-CELLS, airways, viral infection, dendritic cell, HOUSE-DUST MITE, TRANSCRIPTION FACTOR ZDC, BRONCHIAL LYMPH-NODE, INFLUENZA-A VIRUS, MHC CLASS-I, SYNCYTIAL VIRUS, VIRAL-INFECTION, ANTIGEN PRESENTATION, STEADY-STATE

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Citation

Please use this url to cite or link to this publication:

MLA
Neyt, Katrijn, and Bart Lambrecht. “The Role of Lung Dendritic Cell Subsets in Immunity to Respiratory Viruses.” IMMUNOLOGICAL REVIEWS 255.1 (2013): 57–67. Print.
APA
Neyt, Katrijn, & Lambrecht, B. (2013). The role of lung dendritic cell subsets in immunity to respiratory viruses. IMMUNOLOGICAL REVIEWS, 255(1), 57–67.
Chicago author-date
Neyt, Katrijn, and Bart Lambrecht. 2013. “The Role of Lung Dendritic Cell Subsets in Immunity to Respiratory Viruses.” Immunological Reviews 255 (1): 57–67.
Chicago author-date (all authors)
Neyt, Katrijn, and Bart Lambrecht. 2013. “The Role of Lung Dendritic Cell Subsets in Immunity to Respiratory Viruses.” Immunological Reviews 255 (1): 57–67.
Vancouver
1.
Neyt K, Lambrecht B. The role of lung dendritic cell subsets in immunity to respiratory viruses. IMMUNOLOGICAL REVIEWS. 2013;255(1):57–67.
IEEE
[1]
K. Neyt and B. Lambrecht, “The role of lung dendritic cell subsets in immunity to respiratory viruses,” IMMUNOLOGICAL REVIEWS, vol. 255, no. 1, pp. 57–67, 2013.
@article{4128135,
  abstract     = {Viral infections are a common cause of acute respiratory disease. The clinical course of infection and symptoms depend on the viral strain, the health status of the host, and the immunological status of the host. Dendritic cells (DCs) play a crucial role in recognizing and presenting viral antigens and in inducing adaptive immune responses that clear the virus. Because the lung is continuously exposed to the air, the lung is equipped with an elaborate network of DCs to sense incoming foreign pathogens. Increasing knowledge on DC biology has informed us that DCs are not a single cell type. In the steady state lung, three DC subsets can be defined: CD11b(+) or CD103(+) conventional DCs and plasmacytoid DCs. Upon inflammation, inflammatory monocyte-derived DCs are recruited to the lung. It is only recently that tools became available to allow DC subsets to be clearly studied. This review focuses on the activation of DCs and the function of lung DCs in the context of respiratory virus infection and highlights some cautionary points for interpreting older experiments.},
  author       = {Neyt, Katrijn and Lambrecht, Bart},
  issn         = {0105-2896},
  journal      = {IMMUNOLOGICAL REVIEWS},
  keywords     = {lung,CD8(+) T-CELLS,airways,viral infection,dendritic cell,HOUSE-DUST MITE,TRANSCRIPTION FACTOR ZDC,BRONCHIAL LYMPH-NODE,INFLUENZA-A VIRUS,MHC CLASS-I,SYNCYTIAL VIRUS,VIRAL-INFECTION,ANTIGEN PRESENTATION,STEADY-STATE},
  language     = {eng},
  number       = {1},
  pages        = {57--67},
  title        = {The role of lung dendritic cell subsets in immunity to respiratory viruses},
  url          = {http://dx.doi.org/10.1111/imr.12100},
  volume       = {255},
  year         = {2013},
}
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