Transforming growth factor β1 in nasal remodeling : differences between chronic rhinosinusitis and nasal polyposis
- Author
- Jean-Baptiste Watelet (UGent) , Cindy Claeys (UGent) , Claudina Perez-Novo, Philippe Gevaert (UGent) , Paul Van Cauwenberge (UGent) and Claus Bachert (UGent)
- Organization
- Abstract
- Background: Chronic rhinosinusitis (CRS) and nasal polyposis (NP) are histopathologically characterized by different gross morphological aspects. Transforming growth factor (TGF) beta1 plays an important role in tissue remodeling, which is poorly understood in chronic diseases of the sinuses. Methods: The expression of TGF-beta1 was analyzed by enzyme-linked immuno sorbent assay, quantitative reverse-transcription polymerase chain reaction, and immunohistochemistry in nasal tissue from controls (n = 6), CRS (n = 19), or NP (n = 19). Results: CRS presented significantly higher concentrations of TGF-beta1 at protein (p = 0.0008) and mRNA levels (p = 0.025) when compared with NP samples. In CRS, TGF-beta1(+) staining of the extracellular matrix was found abundantly and related to fibrosis. In contrast, no TGF-beta1 staining was found in the pseudocyst areas in NP. Conclusion: CRS was histologically characterized by fibrosis, which was reflected by a significantly higher expression of TGF-beta1 at RNA and protein levels when compared with NP. We show that TGF-beta1 expression is related to fibrosis, differentiating CRS without polyps from NP.
- Keywords
- TGF-BETA, T-CELLS, TGF-BETA-1, EXPRESSION, CYTOKINES, SINUSITIS, PROLIFERATION, ACCUMULATION, GROWTH-FACTOR-BETA, EOSINOPHILS
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-412675
- MLA
- Watelet, Jean-Baptiste, et al. “Transforming Growth Factor Β1 in Nasal Remodeling : Differences between Chronic Rhinosinusitis and Nasal Polyposis.” AMERICAN JOURNAL OF RHINOLOGY, vol. 18, no. 5, 2004, pp. 267–72.
- APA
- Watelet, J.-B., Claeys, C., Perez-Novo, C., Gevaert, P., Van Cauwenberge, P., & Bachert, C. (2004). Transforming growth factor β1 in nasal remodeling : differences between chronic rhinosinusitis and nasal polyposis. AMERICAN JOURNAL OF RHINOLOGY, 18(5), 267–272.
- Chicago author-date
- Watelet, Jean-Baptiste, Cindy Claeys, Claudina Perez-Novo, Philippe Gevaert, Paul Van Cauwenberge, and Claus Bachert. 2004. “Transforming Growth Factor Β1 in Nasal Remodeling : Differences between Chronic Rhinosinusitis and Nasal Polyposis.” AMERICAN JOURNAL OF RHINOLOGY 18 (5): 267–72.
- Chicago author-date (all authors)
- Watelet, Jean-Baptiste, Cindy Claeys, Claudina Perez-Novo, Philippe Gevaert, Paul Van Cauwenberge, and Claus Bachert. 2004. “Transforming Growth Factor Β1 in Nasal Remodeling : Differences between Chronic Rhinosinusitis and Nasal Polyposis.” AMERICAN JOURNAL OF RHINOLOGY 18 (5): 267–272.
- Vancouver
- 1.Watelet J-B, Claeys C, Perez-Novo C, Gevaert P, Van Cauwenberge P, Bachert C. Transforming growth factor β1 in nasal remodeling : differences between chronic rhinosinusitis and nasal polyposis. AMERICAN JOURNAL OF RHINOLOGY. 2004;18(5):267–72.
- IEEE
- [1]J.-B. Watelet, C. Claeys, C. Perez-Novo, P. Gevaert, P. Van Cauwenberge, and C. Bachert, “Transforming growth factor β1 in nasal remodeling : differences between chronic rhinosinusitis and nasal polyposis,” AMERICAN JOURNAL OF RHINOLOGY, vol. 18, no. 5, pp. 267–272, 2004.
@article{412675, abstract = {{Background: Chronic rhinosinusitis (CRS) and nasal polyposis (NP) are histopathologically characterized by different gross morphological aspects. Transforming growth factor (TGF) beta1 plays an important role in tissue remodeling, which is poorly understood in chronic diseases of the sinuses. Methods: The expression of TGF-beta1 was analyzed by enzyme-linked immuno sorbent assay, quantitative reverse-transcription polymerase chain reaction, and immunohistochemistry in nasal tissue from controls (n = 6), CRS (n = 19), or NP (n = 19). Results: CRS presented significantly higher concentrations of TGF-beta1 at protein (p = 0.0008) and mRNA levels (p = 0.025) when compared with NP samples. In CRS, TGF-beta1(+) staining of the extracellular matrix was found abundantly and related to fibrosis. In contrast, no TGF-beta1 staining was found in the pseudocyst areas in NP. Conclusion: CRS was histologically characterized by fibrosis, which was reflected by a significantly higher expression of TGF-beta1 at RNA and protein levels when compared with NP. We show that TGF-beta1 expression is related to fibrosis, differentiating CRS without polyps from NP.}}, author = {{Watelet, Jean-Baptiste and Claeys, Cindy and Perez-Novo, Claudina and Gevaert, Philippe and Van Cauwenberge, Paul and Bachert, Claus}}, issn = {{1050-6586}}, journal = {{AMERICAN JOURNAL OF RHINOLOGY}}, keywords = {{TGF-BETA,T-CELLS,TGF-BETA-1,EXPRESSION,CYTOKINES,SINUSITIS,PROLIFERATION,ACCUMULATION,GROWTH-FACTOR-BETA,EOSINOPHILS}}, language = {{eng}}, number = {{5}}, pages = {{267--272}}, title = {{Transforming growth factor β1 in nasal remodeling : differences between chronic rhinosinusitis and nasal polyposis}}, volume = {{18}}, year = {{2004}}, }