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Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with 99mTc-ECD and 123I-5-I-R91150

Kathelijne Peremans UGent, Kurt Audenaert UGent, Frank Coopman UGent, Peter Blanckaert, FILIP JACOBS UGent, Andreas Otte UGent, Francis Verschooten, Henri van Bree UGent, Cornelis Van Heeringen UGent and John Mertens, et al. (2003) EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 30(11). p.1538-1546
abstract
Impulsive aggression in dogs has an important impact on human public health. Better insight into the pathophysiology of this phenomenon could lead to more adequate diagnosis and treatment. Indirect in vivo research on peripheral body fluids and post-mortem studies in impulsive animals and humans indicate a deficient serotonergic system in general and disturbances in the serotonin-2A (5-HT2A) receptor in particular. In this study, brain perfusion and the 5-HT2A receptors were examined in impulsive, aggressive dogs, in comparison with a group of normally behaving animals. In order to decide which dogs to include in this study, owners were asked to describe the general behaviour of the dogs, the circumstances in which aggression occurred and their conduct during aggressive acts. Finally, 19 dogs were retained for this study, showing, according to different behavioural specialists, disinhibited dominance aggression. Functional imaging studies were performed on all these dogs. Single-photon emission tomography (SPET) was used to measure regional brain perfusion using technetium-99m labelled ethyl cysteinate dimer (ECD). The 5-HT2A receptor binding properties were investigated using the selective radioligand iodine-123 labelled 5-I-R91150. A significant increase in uptake of the 5-HT2A radioligand was noted in all cortical areas. No significant alterations were found in regional cortical perfusion, indicating that the increased binding index was not a consequence of increased tracer delivery. This study supports a role for the serotonergic system in canine impulsive aggression.
Please use this url to cite or link to this publication:
author
organization
alternative title
Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with Tc-99m-ECD and I-123-5-I-R91150
year
type
journalArticle (original)
publication status
published
subject
keyword
SEROTONIN RECEPTORS, PHOTON-EMISSION-TOMOGRAPHY, TRYPTOPHAN DEPLETION, SUICIDE VICTIMS, BRAIN PERFUSION, VERVET MONKEYS, CSF5-HIAA, FLUOXETINE, BINDING-SITES, SILVER FOXES
journal title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Eur. J. Nucl. Med. Mol. Imaging
volume
30
issue
11
pages
1538 - 1546
Web of Science type
Article
Web of Science id
000186139700016
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
3.324 (2003)
JCR rank
11/82 (2003)
JCR quartile
1 (2003)
ISSN
1619-7070
DOI
10.1007/s00259-003-1250-x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
412594
handle
http://hdl.handle.net/1854/LU-412594
date created
2004-05-19 16:44:00
date last changed
2014-02-18 15:39:02
@article{412594,
  abstract     = {Impulsive aggression in dogs has an important impact on human public health. Better insight into the pathophysiology of this phenomenon could lead to more adequate diagnosis and treatment. Indirect in vivo research on peripheral body fluids and post-mortem studies in impulsive animals and humans indicate a deficient serotonergic system in general and disturbances in the serotonin-2A (5-HT2A) receptor in particular. In this study, brain perfusion and the 5-HT2A receptors were examined in impulsive, aggressive dogs, in comparison with a group of normally behaving animals. In order to decide which dogs to include in this study, owners were asked to describe the general behaviour of the dogs, the circumstances in which aggression occurred and their conduct during aggressive acts. Finally, 19 dogs were retained for this study, showing, according to different behavioural specialists, disinhibited dominance aggression. Functional imaging studies were performed on all these dogs. Single-photon emission tomography (SPET) was used to measure regional brain perfusion using technetium-99m labelled ethyl cysteinate dimer (ECD). The 5-HT2A receptor binding properties were investigated using the selective radioligand iodine-123 labelled 5-I-R91150. A significant increase in uptake of the 5-HT2A radioligand was noted in all cortical areas. No significant alterations were found in regional cortical perfusion, indicating that the increased binding index was not a consequence of increased tracer delivery. This study supports a role for the serotonergic system in canine impulsive aggression.},
  author       = {Peremans, Kathelijne and Audenaert, Kurt and Coopman, Frank and Blanckaert, Peter and JACOBS, FILIP and Otte, Andreas and Verschooten, Francis and van Bree, Henri and Van Heeringen, Cornelis and Mertens, John and Slegers, Guido and Dierckx, Rudi},
  issn         = {1619-7070},
  journal      = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},
  keyword      = {SEROTONIN RECEPTORS,PHOTON-EMISSION-TOMOGRAPHY,TRYPTOPHAN DEPLETION,SUICIDE VICTIMS,BRAIN PERFUSION,VERVET MONKEYS,CSF5-HIAA,FLUOXETINE,BINDING-SITES,SILVER FOXES},
  language     = {eng},
  number       = {11},
  pages        = {1538--1546},
  title        = {Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with 99mTc-ECD and 123I-5-I-R91150},
  url          = {http://dx.doi.org/10.1007/s00259-003-1250-x},
  volume       = {30},
  year         = {2003},
}

Chicago
Peremans, Kathelijne, Kurt Audenaert, Frank Coopman, Peter Blanckaert, Filip Jacobs, Andreas Otte, Francis Verschooten, et al. 2003. “Estimates of Regional Cerebral Blood Flow and 5-HT2A Receptor Density in Impulsive, Aggressive Dogs with 99mTc-ECD and 123I-5-I-R91150.” European Journal of Nuclear Medicine and Molecular Imaging 30 (11): 1538–1546.
APA
Peremans, K., Audenaert, K., Coopman, F., Blanckaert, P., Jacobs, F., Otte, A., Verschooten, F., et al. (2003). Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with 99mTc-ECD and 123I-5-I-R91150. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 30(11), 1538–1546.
Vancouver
1.
Peremans K, Audenaert K, Coopman F, Blanckaert P, Jacobs F, Otte A, et al. Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with 99mTc-ECD and 123I-5-I-R91150. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2003;30(11):1538–46.
MLA
Peremans, Kathelijne, Kurt Audenaert, Frank Coopman, et al. “Estimates of Regional Cerebral Blood Flow and 5-HT2A Receptor Density in Impulsive, Aggressive Dogs with 99mTc-ECD and 123I-5-I-R91150.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 30.11 (2003): 1538–1546. Print.