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Optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent

Lieselotte De Smet (UGent) , Wim Ceelen (UGent) , Jean Paul Remon (UGent) and Chris Vervaet (UGent)
Author
Organization
Abstract
Intraperitoneal (IP) chemotherapy is an effective way of treating peritoneal carcinomatosis of colorectal origin after complete cytoreduction. Although IP therapy has been already performed for many years, no standardized treatment design has been developed in terms of schedule, residence time, drug, or carrier solution. Because of the fast clearance of the conventional intravenous (IV) drug delivery systems used for IP therapy, a lot of research is performed to optimize IP drug delivery and extend the residence time of the cytotoxic agent in the peritoneal cavity. This paper reviews the recent advances made in drug delivery systems for IP chemotherapy, discussing the use of microparticles, nanoparticles, liposomes, micelles, implants, and injectable depots for IP delivery
Keywords
PREVENTING POSTSURGICAL ADHESIONS, OVARIAN-CANCER, CARRIER SOLUTIONS, TUMOR-GROWTH, CYTOREDUCTIVE SURGERY, TISSUE DISTRIBUTION, COMPLETE RESECTION, PLUS OXALIPLATIN, RANDOMIZED-TRIAL, COLORECTAL PERITONEAL CARCINOMATOSIS

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Please use this url to cite or link to this publication:

MLA
De Smet, Lieselotte et al. “Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent.” SCIENTIFIC WORLD JOURNAL (2013): n. pag. Print.
APA
De Smet, Lieselotte, Ceelen, W., Remon, J. P., & Vervaet, C. (2013). Optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent. SCIENTIFIC WORLD JOURNAL.
Chicago author-date
De Smet, Lieselotte, Wim Ceelen, Jean Paul Remon, and Chris Vervaet. 2013. “Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent.” Scientific World Journal.
Chicago author-date (all authors)
De Smet, Lieselotte, Wim Ceelen, Jean Paul Remon, and Chris Vervaet. 2013. “Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent.” Scientific World Journal.
Vancouver
1.
De Smet L, Ceelen W, Remon JP, Vervaet C. Optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent. SCIENTIFIC WORLD JOURNAL. 2013;
IEEE
[1]
L. De Smet, W. Ceelen, J. P. Remon, and C. Vervaet, “Optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent,” SCIENTIFIC WORLD JOURNAL, 2013.
@article{4116947,
  abstract     = {Intraperitoneal (IP) chemotherapy is an effective way of treating peritoneal carcinomatosis of colorectal origin after complete cytoreduction. Although IP therapy has been already performed for many years, no standardized treatment design has been developed in terms of schedule, residence time, drug, or carrier solution. Because of the fast clearance of the conventional intravenous (IV) drug delivery systems used for IP therapy, a lot of research is performed to optimize IP drug delivery and extend the residence time of the cytotoxic agent in the peritoneal cavity. This paper reviews the recent advances made in drug delivery systems for IP chemotherapy, discussing the use of microparticles, nanoparticles, liposomes, micelles, implants, and injectable depots for IP delivery},
  articleno    = {720858},
  author       = {De Smet, Lieselotte and Ceelen, Wim and Remon, Jean Paul and Vervaet, Chris},
  issn         = {1537-744X},
  journal      = {SCIENTIFIC WORLD JOURNAL},
  keywords     = {PREVENTING POSTSURGICAL ADHESIONS,OVARIAN-CANCER,CARRIER SOLUTIONS,TUMOR-GROWTH,CYTOREDUCTIVE SURGERY,TISSUE DISTRIBUTION,COMPLETE RESECTION,PLUS OXALIPLATIN,RANDOMIZED-TRIAL,COLORECTAL PERITONEAL CARCINOMATOSIS},
  language     = {eng},
  pages        = {7},
  title        = {Optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent},
  url          = {http://dx.doi.org/10.1155/2013/720858},
  year         = {2013},
}

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