Advanced search
1 file | 666.10 KB

Caspase-14 overexpression in hairless mice is not involved in utricle formation

Michael Devos (UGent) , Philippe De Groote (UGent) , Barbara Gilbert (UGent) , Inge Bruggeman (UGent) , Kirsten Leurs (UGent) , Saskia Lippens (UGent) , Peter Vandenabeele (UGent) and Wim Declercq (UGent)
(2013) EXPERIMENTAL DERMATOLOGY. 22(7). p.484-486
Author
Organization
Abstract
Loss of functional hairless (HR) transcriptional repressor leads to utricle formation and congenital hair loss both in mice and men. Studies in mice have shown that this is preceded by overexpression of caspase-14 at the infundibulum in the hair follicle before conversion to utricle occurs. In this report, we show that HR regulates caspase-14 expression dependent on its interaction with histone deacetylases, implicating chromatin remodelling in the transcriptional regulation of caspase-14. However, crossing hairless mutant mice with caspase-14-deficient mice revealed that caspase-14 overexpression is not the cause of utricle formation.
Keywords
TERMINAL DIFFERENTIATION, PAPULAR LESIONS, HDAC, hairless, caspase-14, GENE, EPIGENETIC REGULATION, SKIN, KERATINOCYTES, EXPRESSION, MUTATION, COREPRESSOR, ALOPECIA

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 666.10 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Devos, Michael, Philippe De Groote, Barbara Gilbert, Inge Bruggeman, Kirsten Leurs, Saskia Lippens, Peter Vandenabeele, and Wim Declercq. 2013. “Caspase-14 Overexpression in Hairless Mice Is Not Involved in Utricle Formation.” Experimental Dermatology 22 (7): 484–486.
APA
Devos, Michael, De Groote, P., Gilbert, B., Bruggeman, I., Leurs, K., Lippens, S., Vandenabeele, P., et al. (2013). Caspase-14 overexpression in hairless mice is not involved in utricle formation. EXPERIMENTAL DERMATOLOGY, 22(7), 484–486.
Vancouver
1.
Devos M, De Groote P, Gilbert B, Bruggeman I, Leurs K, Lippens S, et al. Caspase-14 overexpression in hairless mice is not involved in utricle formation. EXPERIMENTAL DERMATOLOGY. 2013;22(7):484–6.
MLA
Devos, Michael, Philippe De Groote, Barbara Gilbert, et al. “Caspase-14 Overexpression in Hairless Mice Is Not Involved in Utricle Formation.” EXPERIMENTAL DERMATOLOGY 22.7 (2013): 484–486. Print.
@article{4109334,
  abstract     = {Loss of functional hairless (HR) transcriptional repressor leads to utricle formation and congenital hair loss both in mice and men. Studies in mice have shown that this is preceded by overexpression of caspase-14 at the infundibulum in the hair follicle before conversion to utricle occurs. In this report, we show that HR regulates caspase-14 expression dependent on its interaction with histone deacetylases, implicating chromatin remodelling in the transcriptional regulation of caspase-14. However, crossing hairless mutant mice with caspase-14-deficient mice revealed that caspase-14 overexpression is not the cause of utricle formation.},
  author       = {Devos, Michael and De Groote, Philippe and Gilbert, Barbara and Bruggeman, Inge and Leurs, Kirsten and Lippens, Saskia and Vandenabeele, Peter and Declercq, Wim},
  issn         = {0906-6705},
  journal      = {EXPERIMENTAL DERMATOLOGY},
  language     = {eng},
  number       = {7},
  pages        = {484--486},
  title        = {Caspase-14 overexpression in hairless mice is not involved in utricle formation},
  url          = {http://dx.doi.org/10.1111/exd.12165},
  volume       = {22},
  year         = {2013},
}

Altmetric
View in Altmetric
Web of Science
Times cited: