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Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study

Sandra Oeyen (UGent) , Dominique Benoit (UGent) , Lieven Annemans (UGent) , Pieter Depuydt (UGent) , Simon Van Belle (UGent) , Roberto Troisi (UGent) , Lucien Noens (UGent) , Piet Pattyn (UGent) and Johan Decruyenaere (UGent)
(2013) INTENSIVE CARE MEDICINE. 39(5). p.889-898
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Abstract
Data concerning long-term outcomes and quality of life (QOL) in critically ill cancer patients are scarce. The aims of this study were to assess long-term outcomes and QOL in critically ill patients with hematological (HM) or solid malignancies (SM) 3 months and 1 year after intensive care unit (ICU) discharge, to compare these with QOL before ICU admission, and to identify prognostic indicators of long-term QOL. During a 1 year prospective observational cohort analysis, consecutive patients with HM or SM admitted to the medical or surgical ICU of a university hospital were screened for inclusion. Cancer data, demographics, co-morbidity, severity of illness, organ failures, and outcomes were collected. The QOL before ICU admission, 3 months, and 1 year after ICU discharge was assessed using standardized questionnaires (EuroQoL-5D, Medical Outcomes Study 36-item Short Form Health Survey). Statistical significance was attained at P < 0.05. There were 483 patients (85 HM, 398 SM) (64 % men) with a median age of 62 years included. Mortality rates of HM compared to SM were, respectively: hospital (34 vs. 13 %), 3 months (42 vs. 17 %), and 1 year (66 vs. 36 %) (P < 0.001). QOL declined at 3 months, but improved at 1 year although it remained under baseline QOL, particularly in HM. Older age (P = 0.007), severe comorbidity (P = 0.035), and HM (P = 0.041) were independently associated with poorer QOL at 1 year. Long-term outcomes and QOL were poor, particularly in HM. Long-term expectations should play a larger role during multidisciplinary triage decisions upon referral to the ICU.
Keywords
SURVIVAL, VALIDITY, PROGNOSIS, FAILURE, CASE VOLUME, INTENSIVE-CARE-UNIT, HEALTH SURVEY SF-36, SEPTIC SHOCK, INTRAVENOUS CHEMOTHERAPY, Quality of life, Solid tumor, Hematological malignancy, Long-term outcomes, Critically ill patient, CANCER-PATIENTS

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MLA
Oeyen, Sandra, Dominique Benoit, Lieven Annemans, et al. “Long-term Outcomes and Quality of Life in Critically Ill Patients with Hematological or Solid Malignancies: a Single Center Study.” INTENSIVE CARE MEDICINE 39.5 (2013): 889–898. Print.
APA
Oeyen, S., Benoit, D., Annemans, L., Depuydt, P., Van Belle, S., Troisi, R., Noens, L., et al. (2013). Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study. INTENSIVE CARE MEDICINE, 39(5), 889–898.
Chicago author-date
Oeyen, Sandra, Dominique Benoit, Lieven Annemans, Pieter Depuydt, Simon Van Belle, Roberto Troisi, Lucien Noens, Piet Pattyn, and Johan Decruyenaere. 2013. “Long-term Outcomes and Quality of Life in Critically Ill Patients with Hematological or Solid Malignancies: a Single Center Study.” Intensive Care Medicine 39 (5): 889–898.
Chicago author-date (all authors)
Oeyen, Sandra, Dominique Benoit, Lieven Annemans, Pieter Depuydt, Simon Van Belle, Roberto Troisi, Lucien Noens, Piet Pattyn, and Johan Decruyenaere. 2013. “Long-term Outcomes and Quality of Life in Critically Ill Patients with Hematological or Solid Malignancies: a Single Center Study.” Intensive Care Medicine 39 (5): 889–898.
Vancouver
1.
Oeyen S, Benoit D, Annemans L, Depuydt P, Van Belle S, Troisi R, et al. Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study. INTENSIVE CARE MEDICINE. 2013;39(5):889–98.
IEEE
[1]
S. Oeyen et al., “Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study,” INTENSIVE CARE MEDICINE, vol. 39, no. 5, pp. 889–898, 2013.
@article{4106818,
  abstract     = {Data concerning long-term outcomes and quality of life (QOL) in critically ill cancer patients are scarce. The aims of this study were to assess long-term outcomes and QOL in critically ill patients with hematological (HM) or solid malignancies (SM) 3 months and 1 year after intensive care unit (ICU) discharge, to compare these with QOL before ICU admission, and to identify prognostic indicators of long-term QOL.
During a 1 year prospective observational cohort analysis, consecutive patients with HM or SM admitted to the medical or surgical ICU of a university hospital were screened for inclusion. Cancer data, demographics, co-morbidity, severity of illness, organ failures, and outcomes were collected. The QOL before ICU admission, 3 months, and 1 year after ICU discharge was assessed using standardized questionnaires (EuroQoL-5D, Medical Outcomes Study 36-item Short Form Health Survey). Statistical significance was attained at P < 0.05.
There were 483 patients (85 HM, 398 SM) (64 % men) with a median age of 62 years included. Mortality rates of HM compared to SM were, respectively: hospital (34 vs. 13 %), 3 months (42 vs. 17 %), and 1 year (66 vs. 36 %) (P < 0.001). QOL declined at 3 months, but improved at 1 year although it remained under baseline QOL, particularly in HM. Older age (P = 0.007), severe comorbidity (P = 0.035), and HM (P = 0.041) were independently associated with poorer QOL at 1 year.
Long-term outcomes and QOL were poor, particularly in HM. Long-term expectations should play a larger role during multidisciplinary triage decisions upon referral to the ICU.},
  author       = {Oeyen, Sandra and Benoit, Dominique and Annemans, Lieven and Depuydt, Pieter and Van Belle, Simon and Troisi, Roberto and Noens, Lucien and Pattyn, Piet and Decruyenaere, Johan},
  issn         = {0342-4642},
  journal      = {INTENSIVE CARE MEDICINE},
  keywords     = {SURVIVAL,VALIDITY,PROGNOSIS,FAILURE,CASE VOLUME,INTENSIVE-CARE-UNIT,HEALTH SURVEY SF-36,SEPTIC SHOCK,INTRAVENOUS CHEMOTHERAPY,Quality of life,Solid tumor,Hematological malignancy,Long-term outcomes,Critically ill patient,CANCER-PATIENTS},
  language     = {eng},
  number       = {5},
  pages        = {889--898},
  title        = {Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study},
  url          = {http://dx.doi.org/10.1007/s00134-012-2791-x},
  volume       = {39},
  year         = {2013},
}

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