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Caspase-7 participates in differentiation of cells forming dental hard tissues

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Abstract
Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices.
Keywords
odontoblast, MOLAR TOOTH DEVELOPMENT, cell differentiation, caspase, apoptosis, ameloblast, STEM-CELLS, DEFICIENT MICE, FACTORS FAS, APOPTOSIS, EXPRESSION, MESENCHYME, DENTITION, PROTEINS, SURVIVAL

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Citation

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Chicago
Matalova, Eva, Herve Lesot, Eva Svandova, Tom Vanden Berghe, Paul T Sharpe, Christopher Healy, Peter Vandenabeele, and Abigail S Tucker. 2013. “Caspase-7 Participates in Differentiation of Cells Forming Dental Hard Tissues.” Development Growth & Differentiation 55 (5): 615–621.
APA
Matalova, Eva, Lesot, H., Svandova, E., Vanden Berghe, T., Sharpe, P. T., Healy, C., Vandenabeele, P., et al. (2013). Caspase-7 participates in differentiation of cells forming dental hard tissues. DEVELOPMENT GROWTH & DIFFERENTIATION, 55(5), 615–621.
Vancouver
1.
Matalova E, Lesot H, Svandova E, Vanden Berghe T, Sharpe PT, Healy C, et al. Caspase-7 participates in differentiation of cells forming dental hard tissues. DEVELOPMENT GROWTH & DIFFERENTIATION. 2013;55(5):615–21.
MLA
Matalova, Eva, Herve Lesot, Eva Svandova, et al. “Caspase-7 Participates in Differentiation of Cells Forming Dental Hard Tissues.” DEVELOPMENT GROWTH & DIFFERENTIATION 55.5 (2013): 615–621. Print.
@article{4106408,
  abstract     = {Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices.},
  author       = {Matalova, Eva and Lesot, Herve and Svandova, Eva and Vanden Berghe, Tom and Sharpe, Paul T and Healy, Christopher and Vandenabeele, Peter and Tucker, Abigail S},
  issn         = {0012-1592},
  journal      = {DEVELOPMENT GROWTH \& DIFFERENTIATION},
  language     = {eng},
  number       = {5},
  pages        = {615--621},
  title        = {Caspase-7 participates in differentiation of cells forming dental hard tissues},
  url          = {http://dx.doi.org/10.1111/dgd.12066},
  volume       = {55},
  year         = {2013},
}

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