Advanced search
1 file | 1.40 MB Add to list

Epigenetic changes in lymphocytes of solvent-exposed individuals

(2012) EPIGENOMICS. 4(3). p.269-277
Author
Organization
Abstract
Aim: We investigated global DNA methylation alterations in lymphocytes of solvent workers and chronic toxic encephalopathy (CTE) patients and explored potential gene-environment interactions for GST. Population & methods: A cross-sectional study was set up in 41 referents, 128 solvent workers and 23 CTE patients. Results: We found a global DNA hypermethylation in the solvent-exposed population compared with the referents (p = 0.001, r = -0.544). Global DNA methylation was negatively associated with exposure. Furthermore, GSTP1 genotypic polymorphism was found to be significantly associated (p = 0.033) with global DNA hypomethylation, which indicates a potential role for gene-environment interaction in the etiology of solvent-induced neurobehavioral disorders. Conclusion: This study indicates that solvent-induced DNA methylation alterations have an impact on neurotoxicity and development of CTE.
Keywords
RISK, MECHANISMS, HYDROCARBONS, SCHIZOPHRENIA, ENCEPHALOPATHY, CARCINOGENESIS, HYPOMETHYLATION, CELLS, DNA-METHYLATION, neurotoxicity syndromes, occupational exposure, solvents, toxicology, metabolism, genetic predisposition to disease, epigenomics, DNA methylation

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.40 MB

Citation

Please use this url to cite or link to this publication:

MLA
Godderis, Lode, Karel De Raedt, Ali M Tabish, et al. “Epigenetic Changes in Lymphocytes of Solvent-exposed Individuals.” EPIGENOMICS 4.3 (2012): 269–277. Print.
APA
Godderis, L., De Raedt, K., Tabish, A. M., Poels, K., Maertens, N., De Ruyck, K., Bulterys, S., et al. (2012). Epigenetic changes in lymphocytes of solvent-exposed individuals. EPIGENOMICS, 4(3), 269–277.
Chicago author-date
Godderis, Lode, Karel De Raedt, Ali M Tabish, Katrien Poels, Nathalie Maertens, Kim De Ruyck, Simon Bulterys, Hubert Thierens, and Maria K Viaene. 2012. “Epigenetic Changes in Lymphocytes of Solvent-exposed Individuals.” Epigenomics 4 (3): 269–277.
Chicago author-date (all authors)
Godderis, Lode, Karel De Raedt, Ali M Tabish, Katrien Poels, Nathalie Maertens, Kim De Ruyck, Simon Bulterys, Hubert Thierens, and Maria K Viaene. 2012. “Epigenetic Changes in Lymphocytes of Solvent-exposed Individuals.” Epigenomics 4 (3): 269–277.
Vancouver
1.
Godderis L, De Raedt K, Tabish AM, Poels K, Maertens N, De Ruyck K, et al. Epigenetic changes in lymphocytes of solvent-exposed individuals. EPIGENOMICS. 2012;4(3):269–77.
IEEE
[1]
L. Godderis et al., “Epigenetic changes in lymphocytes of solvent-exposed individuals,” EPIGENOMICS, vol. 4, no. 3, pp. 269–277, 2012.
@article{4090940,
  abstract     = {Aim: We investigated global DNA methylation alterations in lymphocytes of solvent workers and chronic toxic encephalopathy (CTE) patients and explored potential gene-environment interactions for GST.
Population & methods: A cross-sectional study was set up in 41 referents, 128 solvent workers and 23 CTE patients.
Results: We found a global DNA hypermethylation in the solvent-exposed population compared with the referents (p = 0.001, r = -0.544). Global DNA methylation was negatively associated with exposure. Furthermore, GSTP1 genotypic polymorphism was found to be significantly associated (p = 0.033) with global DNA hypomethylation, which indicates a potential role for gene-environment interaction in the etiology of solvent-induced neurobehavioral disorders.
Conclusion: This study indicates that solvent-induced DNA methylation alterations have an impact on neurotoxicity and development of CTE.},
  author       = {Godderis, Lode and De Raedt, Karel and Tabish, Ali M and Poels, Katrien and Maertens, Nathalie and De Ruyck, Kim and Bulterys, Simon and Thierens, Hubert and Viaene, Maria K},
  issn         = {1750-1911},
  journal      = {EPIGENOMICS},
  keywords     = {RISK,MECHANISMS,HYDROCARBONS,SCHIZOPHRENIA,ENCEPHALOPATHY,CARCINOGENESIS,HYPOMETHYLATION,CELLS,DNA-METHYLATION,neurotoxicity syndromes,occupational exposure,solvents,toxicology,metabolism,genetic predisposition to disease,epigenomics,DNA methylation},
  language     = {eng},
  number       = {3},
  pages        = {269--277},
  title        = {Epigenetic changes in lymphocytes of solvent-exposed individuals},
  volume       = {4},
  year         = {2012},
}

Web of Science
Times cited: