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Genes involved in cerebrospinal fluid production as candidate genes for late onset Alzheimer's disease: a hypothesis

(2011) JOURNAL OF NEUROGENETICS. 25(4). p.195-200
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Abstract
In rare patients with autosomal dominant, early-onset Alzheimer's disease (AD), pathogenic mutations in the genes encoding beta-amyloid precursor protein, and the gamma-secretase-complex components presenilin-1 and presenilin-2 appear to result in beta-amyloid (A beta) overproduction. The pathological accumulation of A beta in the far more common late-onset AD is more likely to be the result of deficient clearance of A beta. There is evidence that production and turnover of cerebrospinal fluid (CSF) help to clear toxic molecules such as A beta from the interstitial fluid space of the brain to the bloodstream. CSF production and turnover have been shown to be decreased in aging and in pathological conditions, such as normal pressure hydrocephalus and AD. Reduced formation of CSF, with diminished clearance of A beta, may play an important role in the onset and progression of AD. If reduced CSF turnover is a risk factor for AD, then its incidence ought to be increased under conditions of CSF circulatory failure. In this paper, the authors hypothesize that genes and variations of genes involved in the CSF production and absorption may contribute to the pathogenesis of late-onset AD.
Keywords
Alzheimer's disease, aquaporin 1, carbonic anhydrase II, cerebrospinal fluid pressure, cerebrospinal fluid production, choroid plexus, intracranial pressure, Na(+), K(+)-ATPase, SLC4A10, NORMAL-PRESSURE HYDROCEPHALUS, OPEN-ANGLE GLAUCOMA, GENOME-WIDE ASSOCIATION, TRANSPORTER EXPRESSION, INTRACRANIAL-PRESSURE, IDENTIFIES VARIANTS, CHOROID-PLEXUS, BRAIN, SUSCEPTIBILITY, PROTEINS

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Citation

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MLA
Wostyn, Peter, Debby Van Dam, Kurt Audenaert, et al. “Genes Involved in Cerebrospinal Fluid Production as Candidate Genes for Late Onset Alzheimer’s Disease: a Hypothesis.” JOURNAL OF NEUROGENETICS 25.4 (2011): 195–200. Print.
APA
Wostyn, Peter, Van Dam, D., Audenaert, K., & De Deyn, P. P. (2011). Genes involved in cerebrospinal fluid production as candidate genes for late onset Alzheimer’s disease: a hypothesis. JOURNAL OF NEUROGENETICS, 25(4), 195–200.
Chicago author-date
Wostyn, Peter, Debby Van Dam, Kurt Audenaert, and Peter Paul De Deyn. 2011. “Genes Involved in Cerebrospinal Fluid Production as Candidate Genes for Late Onset Alzheimer’s Disease: a Hypothesis.” Journal of Neurogenetics 25 (4): 195–200.
Chicago author-date (all authors)
Wostyn, Peter, Debby Van Dam, Kurt Audenaert, and Peter Paul De Deyn. 2011. “Genes Involved in Cerebrospinal Fluid Production as Candidate Genes for Late Onset Alzheimer’s Disease: a Hypothesis.” Journal of Neurogenetics 25 (4): 195–200.
Vancouver
1.
Wostyn P, Van Dam D, Audenaert K, De Deyn PP. Genes involved in cerebrospinal fluid production as candidate genes for late onset Alzheimer’s disease: a hypothesis. JOURNAL OF NEUROGENETICS. 2011;25(4):195–200.
IEEE
[1]
P. Wostyn, D. Van Dam, K. Audenaert, and P. P. De Deyn, “Genes involved in cerebrospinal fluid production as candidate genes for late onset Alzheimer’s disease: a hypothesis,” JOURNAL OF NEUROGENETICS, vol. 25, no. 4, pp. 195–200, 2011.
@article{4088285,
  abstract     = {{In rare patients with autosomal dominant, early-onset Alzheimer's disease (AD), pathogenic mutations in the genes encoding beta-amyloid precursor protein, and the gamma-secretase-complex components presenilin-1 and presenilin-2 appear to result in beta-amyloid (A beta) overproduction. The pathological accumulation of A beta in the far more common late-onset AD is more likely to be the result of deficient clearance of A beta. There is evidence that production and turnover of cerebrospinal fluid (CSF) help to clear toxic molecules such as A beta from the interstitial fluid space of the brain to the bloodstream. CSF production and turnover have been shown to be decreased in aging and in pathological conditions, such as normal pressure hydrocephalus and AD. Reduced formation of CSF, with diminished clearance of A beta, may play an important role in the onset and progression of AD. If reduced CSF turnover is a risk factor for AD, then its incidence ought to be increased under conditions of CSF circulatory failure. In this paper, the authors hypothesize that genes and variations of genes involved in the CSF production and absorption may contribute to the pathogenesis of late-onset AD.}},
  author       = {{Wostyn, Peter and Van Dam, Debby and Audenaert, Kurt and De Deyn, Peter Paul}},
  issn         = {{0167-7063}},
  journal      = {{JOURNAL OF NEUROGENETICS}},
  keywords     = {{Alzheimer's disease,aquaporin 1,carbonic anhydrase II,cerebrospinal fluid pressure,cerebrospinal fluid production,choroid plexus,intracranial pressure,Na(+),K(+)-ATPase,SLC4A10,NORMAL-PRESSURE HYDROCEPHALUS,OPEN-ANGLE GLAUCOMA,GENOME-WIDE ASSOCIATION,TRANSPORTER EXPRESSION,INTRACRANIAL-PRESSURE,IDENTIFIES VARIANTS,CHOROID-PLEXUS,BRAIN,SUSCEPTIBILITY,PROTEINS}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{195--200}},
  title        = {{Genes involved in cerebrospinal fluid production as candidate genes for late onset Alzheimer's disease: a hypothesis}},
  url          = {{http://dx.doi.org/10.3109/01677063.2011.620191}},
  volume       = {{25}},
  year         = {{2011}},
}

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