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Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study

Julie Bolcaen, Marjan Acou UGent, Koen Mertens, GIORGIO HALLAERT, Caroline Van den Broecke UGent, Eric Achten UGent and Ingeborg Goethals UGent (2013) JOURNAL OF NEUROIMAGING. 23(3). p.431-436
abstract
BACKGROUND : Multimodality imaging such as proton magnetic resonance spectroscopy (MRS) and positron emission tomography (PET) have provided information specific to the underlying mechanisms of many brain diseases, including multiple sclerosis (MS). PURPOSE : To determine the structural and metabolic characterization of two particular variants of MS, namely tumefactive MS and Balo's concentric sclerosis (BCS). METHODS : Conventional MR imaging, diffusion and perfusion MR, MR spectroscopy and PET imaging with F-18 fluorodeoxyglucose (FDG) and F-18 fluoromethylcholine (FCho) were performed. RESULTS : In a case with pathologically proven tumefactive MS, magnetic resonance imaging (MRI) showed a pseudotumoral lesion with incomplete ring enhancement, peripheral diffusion restriction, and high choline and lactate peaks on MRS. On follow-up, the lesion showed significant growth. In a case of BCS, MRI showed an onion-like lesion without contrast enhancement or diffusion restriction, and only a moderate increase in choline on MRS. The lesion remained stable on follow-up. On PET, there was no uptake of F-18 FDG in either type of MS lesion. Conversely, uptake of F-18 FCho was moderate in tumefactive MS, whereas no F-18 FCho uptake was noted in the lesion with, on MRI, typical features of BCS. CONCLUSIONS : Our findings illustrate that metabolic features may differ between variants of MS possibly signifying different disease activity.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MRI, Multiple sclerosis, MR spectroscopy, PET, F-18 fluoromethylcholine, F-18 fluorodeoxyglucose, POSITRON-EMISSION-TOMOGRAPHY, PROTON MR SPECTROSCOPY, TUMOR
journal title
JOURNAL OF NEUROIMAGING
J. Neuroimaging
volume
23
issue
3
pages
431 - 436
Web of Science type
Article
Web of Science id
000321213500021
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
1.818 (2013)
JCR rank
54/122 (2013)
JCR quartile
2 (2013)
ISSN
1051-2284
DOI
10.1111/j.1552-6569.2012.00760.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4085501
handle
http://hdl.handle.net/1854/LU-4085501
date created
2013-06-25 12:51:41
date last changed
2016-12-19 15:43:21
@article{4085501,
  abstract     = {BACKGROUND : Multimodality imaging such as proton magnetic resonance spectroscopy (MRS) and positron emission tomography (PET) have provided information specific to the underlying mechanisms of many brain diseases, including multiple sclerosis (MS). 
PURPOSE : To determine the structural and metabolic characterization of two particular variants of MS, namely tumefactive MS and Balo's concentric sclerosis (BCS). 
METHODS : Conventional MR imaging, diffusion and perfusion MR, MR spectroscopy and PET imaging with F-18 fluorodeoxyglucose (FDG) and F-18 fluoromethylcholine (FCho) were performed. 
RESULTS : In a case with pathologically proven tumefactive MS, magnetic resonance imaging (MRI) showed a pseudotumoral lesion with incomplete ring enhancement, peripheral diffusion restriction, and high choline and lactate peaks on MRS. On follow-up, the lesion showed significant growth. In a case of BCS, MRI showed an onion-like lesion without contrast enhancement or diffusion restriction, and only a moderate increase in choline on MRS. The lesion remained stable on follow-up. On PET, there was no uptake of F-18 FDG in either type of MS lesion. Conversely, uptake of F-18 FCho was moderate in tumefactive MS, whereas no F-18 FCho uptake was noted in the lesion with, on MRI, typical features of BCS. 
CONCLUSIONS : Our findings illustrate that metabolic features may differ between variants of MS possibly signifying different disease activity.},
  author       = {Bolcaen, Julie and Acou, Marjan and Mertens, Koen and HALLAERT, GIORGIO and Van den Broecke, Caroline and Achten, Eric and Goethals, Ingeborg},
  issn         = {1051-2284},
  journal      = {JOURNAL OF NEUROIMAGING},
  keyword      = {MRI,Multiple sclerosis,MR spectroscopy,PET,F-18 fluoromethylcholine,F-18 fluorodeoxyglucose,POSITRON-EMISSION-TOMOGRAPHY,PROTON MR SPECTROSCOPY,TUMOR},
  language     = {eng},
  number       = {3},
  pages        = {431--436},
  title        = {Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study},
  url          = {http://dx.doi.org/10.1111/j.1552-6569.2012.00760.x},
  volume       = {23},
  year         = {2013},
}

Chicago
Bolcaen, Julie, Marjan Acou, Koen Mertens, GIORGIO HALLAERT, Caroline Van den Broecke, Eric Achten, and Ingeborg Goethals. 2013. “Structural and Metabolic Features of Two Different Variants of Multiple Sclerosis: a PET/MRI Study.” Journal of Neuroimaging 23 (3): 431–436.
APA
Bolcaen, J., Acou, M., Mertens, K., HALLAERT, G., Van den Broecke, C., Achten, E., & Goethals, I. (2013). Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study. JOURNAL OF NEUROIMAGING, 23(3), 431–436.
Vancouver
1.
Bolcaen J, Acou M, Mertens K, HALLAERT G, Van den Broecke C, Achten E, et al. Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study. JOURNAL OF NEUROIMAGING. 2013;23(3):431–6.
MLA
Bolcaen, Julie, Marjan Acou, Koen Mertens, et al. “Structural and Metabolic Features of Two Different Variants of Multiple Sclerosis: a PET/MRI Study.” JOURNAL OF NEUROIMAGING 23.3 (2013): 431–436. Print.