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Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study

Julie Bolcaen (UGent) , Marjan Acou (UGent) , Koen Mertens (UGent) , GIORGIO HALLAERT (UGent) , Caroline Van den Broecke (UGent) , Eric Achten (UGent) and Ingeborg Goethals (UGent)
(2013) JOURNAL OF NEUROIMAGING. 23(3). p.431-436
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Abstract
BACKGROUND : Multimodality imaging such as proton magnetic resonance spectroscopy (MRS) and positron emission tomography (PET) have provided information specific to the underlying mechanisms of many brain diseases, including multiple sclerosis (MS). PURPOSE : To determine the structural and metabolic characterization of two particular variants of MS, namely tumefactive MS and Balo's concentric sclerosis (BCS). METHODS : Conventional MR imaging, diffusion and perfusion MR, MR spectroscopy and PET imaging with F-18 fluorodeoxyglucose (FDG) and F-18 fluoromethylcholine (FCho) were performed. RESULTS : In a case with pathologically proven tumefactive MS, magnetic resonance imaging (MRI) showed a pseudotumoral lesion with incomplete ring enhancement, peripheral diffusion restriction, and high choline and lactate peaks on MRS. On follow-up, the lesion showed significant growth. In a case of BCS, MRI showed an onion-like lesion without contrast enhancement or diffusion restriction, and only a moderate increase in choline on MRS. The lesion remained stable on follow-up. On PET, there was no uptake of F-18 FDG in either type of MS lesion. Conversely, uptake of F-18 FCho was moderate in tumefactive MS, whereas no F-18 FCho uptake was noted in the lesion with, on MRI, typical features of BCS. CONCLUSIONS : Our findings illustrate that metabolic features may differ between variants of MS possibly signifying different disease activity.
Keywords
MRI, Multiple sclerosis, MR spectroscopy, PET, F-18 fluoromethylcholine, F-18 fluorodeoxyglucose, POSITRON-EMISSION-TOMOGRAPHY, PROTON MR SPECTROSCOPY, TUMOR

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Chicago
Bolcaen, Julie, Marjan Acou, Koen Mertens, GIORGIO HALLAERT, Caroline Van den Broecke, Eric Achten, and Ingeborg Goethals. 2013. “Structural and Metabolic Features of Two Different Variants of Multiple Sclerosis: a PET/MRI Study.” Journal of Neuroimaging 23 (3): 431–436.
APA
Bolcaen, J., Acou, M., Mertens, K., HALLAERT, G., Van den Broecke, C., Achten, E., & Goethals, I. (2013). Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study. JOURNAL OF NEUROIMAGING, 23(3), 431–436.
Vancouver
1.
Bolcaen J, Acou M, Mertens K, HALLAERT G, Van den Broecke C, Achten E, et al. Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study. JOURNAL OF NEUROIMAGING. 2013;23(3):431–6.
MLA
Bolcaen, Julie, Marjan Acou, Koen Mertens, et al. “Structural and Metabolic Features of Two Different Variants of Multiple Sclerosis: a PET/MRI Study.” JOURNAL OF NEUROIMAGING 23.3 (2013): 431–436. Print.
@article{4085501,
  abstract     = {BACKGROUND : Multimodality imaging such as proton magnetic resonance spectroscopy (MRS) and positron emission tomography (PET) have provided information specific to the underlying mechanisms of many brain diseases, including multiple sclerosis (MS). 
PURPOSE : To determine the structural and metabolic characterization of two particular variants of MS, namely tumefactive MS and Balo's concentric sclerosis (BCS). 
METHODS : Conventional MR imaging, diffusion and perfusion MR, MR spectroscopy and PET imaging with F-18 fluorodeoxyglucose (FDG) and F-18 fluoromethylcholine (FCho) were performed. 
RESULTS : In a case with pathologically proven tumefactive MS, magnetic resonance imaging (MRI) showed a pseudotumoral lesion with incomplete ring enhancement, peripheral diffusion restriction, and high choline and lactate peaks on MRS. On follow-up, the lesion showed significant growth. In a case of BCS, MRI showed an onion-like lesion without contrast enhancement or diffusion restriction, and only a moderate increase in choline on MRS. The lesion remained stable on follow-up. On PET, there was no uptake of F-18 FDG in either type of MS lesion. Conversely, uptake of F-18 FCho was moderate in tumefactive MS, whereas no F-18 FCho uptake was noted in the lesion with, on MRI, typical features of BCS. 
CONCLUSIONS : Our findings illustrate that metabolic features may differ between variants of MS possibly signifying different disease activity.},
  author       = {Bolcaen, Julie and Acou, Marjan and Mertens, Koen and HALLAERT, GIORGIO and Van den Broecke, Caroline and Achten, Eric and Goethals, Ingeborg},
  issn         = {1051-2284},
  journal      = {JOURNAL OF NEUROIMAGING},
  keyword      = {MRI,Multiple sclerosis,MR spectroscopy,PET,F-18 fluoromethylcholine,F-18 fluorodeoxyglucose,POSITRON-EMISSION-TOMOGRAPHY,PROTON MR SPECTROSCOPY,TUMOR},
  language     = {eng},
  number       = {3},
  pages        = {431--436},
  title        = {Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study},
  url          = {http://dx.doi.org/10.1111/j.1552-6569.2012.00760.x},
  volume       = {23},
  year         = {2013},
}

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