The role of Ca2+-channel blockers in the transition from ventricular fibrillation to ventricular tachycardia in an anatomical model of the human ventricles : a simulation study
- Author
- Olivier Bernus (UGent) , Henri Verschelde (UGent) and Alexander Panfilov (UGent)
- Organization
- Abstract
- We have investigated the effect of blocking the Ca2+-channel on the transition from fibrillation to tachycardia in simulations in an anatomical model of the human ventricles, using a previously developed model of human ventricular cells where ventricular fibrillation was obtained by the process of spiral wave breakup. We show that blocking the Ca2+-current by 75% can convert fibrilliation into a periodic regime with a single stable spiral waves, which anchored to an anatomical obstacle. We show that the observed effects were due to a flattening of the restitution curve, which prevented the generation of wave breaks and stabilized the activation patterns.
- Keywords
- fibrilliation, tachycardia, verapamil, DYNAMICS, VERAPAMIL, MYOCYTES, TISSUE
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-403796
- MLA
- Bernus, Olivier, et al. “The Role of Ca2+-Channel Blockers in the Transition from Ventricular Fibrillation to Ventricular Tachycardia in an Anatomical Model of the Human Ventricles : A Simulation Study.” Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-4 : A New Beginning for Human Health, vol. 25, IEEE, 2003, pp. 9–12.
- APA
- Bernus, O., Verschelde, H., & Panfilov, A. (2003). The role of Ca2+-channel blockers in the transition from ventricular fibrillation to ventricular tachycardia in an anatomical model of the human ventricles : a simulation study. Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-4 : A New Beginning for Human Health, 25, 9–12. New York, NY, USA: IEEE.
- Chicago author-date
- Bernus, Olivier, Henri Verschelde, and Alexander Panfilov. 2003. “The Role of Ca2+-Channel Blockers in the Transition from Ventricular Fibrillation to Ventricular Tachycardia in an Anatomical Model of the Human Ventricles : A Simulation Study.” In Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-4 : A New Beginning for Human Health, 25:9–12. New York, NY, USA: IEEE.
- Chicago author-date (all authors)
- Bernus, Olivier, Henri Verschelde, and Alexander Panfilov. 2003. “The Role of Ca2+-Channel Blockers in the Transition from Ventricular Fibrillation to Ventricular Tachycardia in an Anatomical Model of the Human Ventricles : A Simulation Study.” In Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-4 : A New Beginning for Human Health, 25:9–12. New York, NY, USA: IEEE.
- Vancouver
- 1.Bernus O, Verschelde H, Panfilov A. The role of Ca2+-channel blockers in the transition from ventricular fibrillation to ventricular tachycardia in an anatomical model of the human ventricles : a simulation study. In: Proceedings of the 25th annual international conference of the IEEE Engineering in Medicine and Biology Society, vols 1-4 : a new beginning for human health. New York, NY, USA: IEEE; 2003. p. 9–12.
- IEEE
- [1]O. Bernus, H. Verschelde, and A. Panfilov, “The role of Ca2+-channel blockers in the transition from ventricular fibrillation to ventricular tachycardia in an anatomical model of the human ventricles : a simulation study,” in Proceedings of the 25th annual international conference of the IEEE Engineering in Medicine and Biology Society, vols 1-4 : a new beginning for human health, Cancún, Mexico, 2003, vol. 25, pp. 9–12.
@inproceedings{403796,
abstract = {{We have investigated the effect of blocking the Ca2+-channel on the transition from fibrillation to tachycardia in simulations in an anatomical model of the human ventricles, using a previously developed model of human ventricular cells where ventricular fibrillation was obtained by the process of spiral wave breakup. We show that blocking the Ca2+-current by 75% can convert fibrilliation into a periodic regime with a single stable spiral waves, which anchored to an anatomical obstacle. We show that the observed effects were due to a flattening of the restitution curve, which prevented the generation of wave breaks and stabilized the activation patterns.}},
author = {{Bernus, Olivier and Verschelde, Henri and Panfilov, Alexander}},
booktitle = {{Proceedings of the 25th annual international conference of the IEEE Engineering in Medicine and Biology Society, vols 1-4 : a new beginning for human health}},
isbn = {{9780780377899}},
issn = {{1094-687X}},
keywords = {{fibrilliation,tachycardia,verapamil,DYNAMICS,VERAPAMIL,MYOCYTES,TISSUE}},
language = {{eng}},
location = {{Cancún, Mexico}},
pages = {{9--12}},
publisher = {{IEEE}},
title = {{The role of Ca2+-channel blockers in the transition from ventricular fibrillation to ventricular tachycardia in an anatomical model of the human ventricles : a simulation study}},
volume = {{25}},
year = {{2003}},
}