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Caspase-14 reveals its secrets

Geertrui Denecker (UGent) , Petra Ovaere (UGent) , Peter Vandenabeele (UGent) and Wim Declercq (UGent)
(2008) JOURNAL OF CELL BIOLOGY. 180(3). p.451-458
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Abstract
Caspase-14 is a unique member of the evolutionarily conserved family of cysteinyl aspartate-specific proteinases, which are mainly involved in inflammation and apoptosis. However, recent evidence also implicates these proteases in proliferation and differentiation. Although most caspases are ubiquitously expressed, caspase-14 expression is confined mainly to cornifying epithelia, such as the skin. Moreover, caspase-14 activation correlates with cornification, indicating that it plays a role in terminal keratinocyte differentiation. The determination of in vitro conditions for caspase- 14 activity paved the way to identifying its substrates. The recent development of caspase-14-deficient mice underscored its importance in the correct degradation of (pro)filaggrin and in the formation of the epidermal barrier that protects against dehydration and UVB radiation. Here, we review the current knowledge on caspase-14 in skin homeostasis and disease.
Keywords
BARRIER FORMATION, PORCINE PANCREATIC ELASTASE, MUTATIONAL ANALYSIS, TERMINAL DIFFERENTIATION, STRATUM-CORNEUM, KERATINOCYTE DIFFERENTIATION, EPIDERMAL DIFFERENTIATION, ICHTHYOSIS VULGARIS, EPITHELIAL-CELLS, SKIN-DISEASE

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Citation

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Chicago
Denecker, Geertrui, Petra Ovaere, Peter Vandenabeele, and Wim Declercq. 2008. “Caspase-14 Reveals Its Secrets.” Journal of Cell Biology 180 (3): 451–458.
APA
Denecker, G., Ovaere, P., Vandenabeele, P., & Declercq, W. (2008). Caspase-14 reveals its secrets. JOURNAL OF CELL BIOLOGY, 180(3), 451–458.
Vancouver
1.
Denecker G, Ovaere P, Vandenabeele P, Declercq W. Caspase-14 reveals its secrets. JOURNAL OF CELL BIOLOGY. 2008;180(3):451–8.
MLA
Denecker, Geertrui, Petra Ovaere, Peter Vandenabeele, et al. “Caspase-14 Reveals Its Secrets.” JOURNAL OF CELL BIOLOGY 180.3 (2008): 451–458. Print.
@article{394311,
  abstract     = {Caspase-14 is a unique member of the evolutionarily conserved family of cysteinyl aspartate-specific proteinases, which are mainly involved in inflammation and apoptosis. However, recent evidence also implicates these proteases in proliferation and differentiation. Although most caspases are ubiquitously expressed, caspase-14 expression is confined mainly to cornifying epithelia, such as the skin. Moreover, caspase-14 activation correlates with cornification, indicating that it plays a role in terminal keratinocyte differentiation. The determination of in vitro conditions for caspase- 14 activity paved the way to identifying its substrates. The recent development of caspase-14-deficient mice underscored its importance in the correct degradation of (pro)filaggrin and in the formation of the epidermal barrier that protects against dehydration and UVB radiation. Here, we review the current knowledge on caspase-14 in skin homeostasis and disease.},
  author       = {Denecker, Geertrui and Ovaere, Petra and Vandenabeele, Peter and Declercq, Wim},
  issn         = {0021-9525},
  journal      = {JOURNAL OF CELL BIOLOGY},
  language     = {eng},
  number       = {3},
  pages        = {451--458},
  title        = {Caspase-14 reveals its secrets},
  url          = {http://dx.doi.org/10.1083/jcb.200709098},
  volume       = {180},
  year         = {2008},
}

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