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Clinical and genetic factors associated with sacroiliitis in Crohn's disease

Harald Peeters UGent, BERT VANDER CRUYSSEN UGent, Herman Mielants UGent, Kurt De Vlam, Severine Vermeire, Edouard Louis, Paul Rurgeerts, Jacques Belaiche and MARTINE DE VOS UGent (2008) JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 23(1). p.132-137
abstract
Background and Aim: Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra-intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI with other clinical features of CD are limited. Association of SI with CARD15 polymorphisms has recently been suggested. In a multicenter study, we investigated the association of SI in CD patients with clinical phenotypes, other EIM and CARD15 polymorphisms. Methods: Radiographs of the sacroiliac joints were taken in 251 CD patients from three Belgian university hospitals and scored by two blinded rheumatologists. Clinical features were obtained from medical records. Forty-three percent of patients carried at least one CARD15 polymorphism. Results: Sacroiliitis, defined as the presence of at least grade 2 unilateral changes, was diagnosed in 65 of the 244 scorable radiographs (27%). Only 16 of these patients were previously diagnosed with ankylosing spondylitis (AS). HLA-B27 positivity was observed in 53% of patients with AS and 7% of patients with radiographic SI. In univariate and multivariate analysis, associations between the presence of SI and peripheral arthritis (P = 0.005) and between AS and uveitis (P = 0.005) were found. No associations with other recorded clinical features or with CARD15 polymorphisms were observed. Conclusion: We confirm the high prevalence of radiographic sacroiliitis in a multicenter CD cohort. Uveitis is only associated with AS whereas all patients with SI are more prone to develop peripheral arthritis during their disease course, suggesting similar pathogenetic mechanisms in the development of these EIM. The previously reported association between SI and CARD15 polymorphisms was not confirmed.
Please use this url to cite or link to this publication:
author
organization
alternative title
Gastroenterology - Clinical and genetic factors associated with sacroiliitis in Crohn's disease
year
type
journalArticle (original)
publication status
published
subject
keyword
CARD15, association, Crohn's disease, extra-intestinal manifestation, sacroiliitis, INFLAMMATORY-BOWEL-DISEASE, ANKYLOSING-SPONDYLITIS, EXTRAINTESTINAL MANIFESTATIONS, ULCERATIVE-COLITIS, SYNOVIAL-FLUID, SPONDYLOARTHROPATHY, PREVALENCE, GUT, COMPLICATIONS, SCINTIGRAPHY
journal title
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
J. Gastroenterol. Hepatol.
volume
23
issue
1
pages
132-137 pages
Web of Science type
Article
Web of Science id
000251671000022
JCR category
GASTROENTEROLOGY & HEPATOLOGY
JCR impact factor
2.275 (2008)
JCR rank
29/55 (2008)
JCR quartile
3 (2008)
ISSN
0815-9319
DOI
10.1111/j.1440-1746.2007.05108.x
language
English
UGent publication?
yes
classification
A1
additional info
alternative title is version of title as it appears in Web of Science
copyright statement
I have transferred the copyright for this publication to the publisher
id
393948
handle
http://hdl.handle.net/1854/LU-393948
date created
2008-03-17 15:04:00
date last changed
2010-05-17 11:54:39
@article{393948,
  abstract     = {Background and Aim: Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra-intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI with other clinical features of CD are limited. Association of SI with CARD15 polymorphisms has recently been suggested. In a multicenter study, we investigated the association of SI in CD patients with clinical phenotypes, other EIM and CARD15 polymorphisms.
Methods: Radiographs of the sacroiliac joints were taken in 251 CD patients from three Belgian university hospitals and scored by two blinded rheumatologists. Clinical features were obtained from medical records. Forty-three percent of patients carried at least one CARD15 polymorphism.
Results: Sacroiliitis, defined as the presence of at least grade 2 unilateral changes, was diagnosed in 65 of the 244 scorable radiographs (27\%). Only 16 of these patients were previously diagnosed with ankylosing spondylitis (AS). HLA-B27 positivity was observed in 53\% of patients with AS and 7\% of patients with radiographic SI. In univariate and multivariate analysis, associations between the presence of SI and peripheral arthritis (P = 0.005) and between AS and uveitis (P = 0.005) were found. No associations with other recorded clinical features or with CARD15 polymorphisms were observed.
Conclusion: We confirm the high prevalence of radiographic sacroiliitis in a multicenter CD cohort. Uveitis is only associated with AS whereas all patients with SI are more prone to develop peripheral arthritis during their disease course, suggesting similar pathogenetic mechanisms in the development of these EIM. The previously reported association between SI and CARD15 polymorphisms was not confirmed.},
  author       = {Peeters, Harald and VANDER CRUYSSEN, BERT and Mielants, Herman and De Vlam, Kurt and Vermeire, Severine and Louis, Edouard and Rurgeerts, Paul and Belaiche, Jacques and DE VOS, MARTINE},
  issn         = {0815-9319},
  journal      = {JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY},
  keyword      = {CARD15,association,Crohn's disease,extra-intestinal manifestation,sacroiliitis,INFLAMMATORY-BOWEL-DISEASE,ANKYLOSING-SPONDYLITIS,EXTRAINTESTINAL MANIFESTATIONS,ULCERATIVE-COLITIS,SYNOVIAL-FLUID,SPONDYLOARTHROPATHY,PREVALENCE,GUT,COMPLICATIONS,SCINTIGRAPHY},
  language     = {eng},
  number       = {1},
  pages        = {132--137},
  title        = {Clinical and genetic factors associated with sacroiliitis in Crohn's disease},
  url          = {http://dx.doi.org/10.1111/j.1440-1746.2007.05108.x},
  volume       = {23},
  year         = {2008},
}

Chicago
Peeters, Harald, BERT VANDER CRUYSSEN, Herman Mielants, Kurt De Vlam, Severine Vermeire, Edouard Louis, Paul Rurgeerts, Jacques Belaiche, and MARTINE DE VOS. 2008. “Clinical and Genetic Factors Associated with Sacroiliitis in Crohn’s Disease.” Journal of Gastroenterology and Hepatology 23 (1): 132–137.
APA
Peeters, Harald, VANDER CRUYSSEN, B., Mielants, H., De Vlam, K., Vermeire, S., Louis, E., Rurgeerts, P., et al. (2008). Clinical and genetic factors associated with sacroiliitis in Crohn’s disease. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 23(1), 132–137.
Vancouver
1.
Peeters H, VANDER CRUYSSEN B, Mielants H, De Vlam K, Vermeire S, Louis E, et al. Clinical and genetic factors associated with sacroiliitis in Crohn’s disease. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2008;23(1):132–7.
MLA
Peeters, Harald, BERT VANDER CRUYSSEN, Herman Mielants, et al. “Clinical and Genetic Factors Associated with Sacroiliitis in Crohn’s Disease.” JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 23.1 (2008): 132–137. Print.