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Endocrine disruptors and abnormalities of pubertal development

Greet Schoeters, Elly Den Hond, Willem Dhooge, Nicolas Van Larebeke UGent and Marike Leijs (2008) BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 102(2). p.168-175
abstract
Onset and development of puberty is regulated by the neuroendocrine system. Population-based studies worldwide have observed secular trends towards earlier puberty development. These changes are apparently caused by environmental factors such as improved socio-economic status, improved health care and nutrition. However, they may also partly result from endocrine-disrupting chemicals in the environment. Epidemiological studies have investigated the relationship between pubertal development and exposure to endocrine-disrupting chemicals (polychlorinated biphenyls, polybrominated biphenyls, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane, phthalate esters, furans and the pesticide endosulfan). Associations with both perinatal and postnatal exposure have been reported. Studies in experimental animals support some of these findings and point to differential endocrine regulatory mechanisms linked to pubertal development acting in the perinatal and the pre-pubertal period. Pubertal development is naturally associated with growth and body composition. There is increasing evidence for a link between prenatal development and pubertal onset. In girls born small for gestational age (SGA), pubertal onset and age at menarche often are advanced, especially if there has been an extensive catch-up growth during the first months of life. In utero growth retardation may have multiple causes including exposure to xenobiotic substances as was suggested for some endocrine-disrupting chemicals. An abnormal perinatal environment of children born SGA may alter the endocrine status and the sensitivity of the receptors for endocrine and metabolic signalling that may have effects on maturation of brain and gonads. However, the causal pathways and the molecular mechanisms that may link the pubertal growth pattern of children born SGA, pubertal development and endocrine-disrupting chemicals need further study.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (proceedingsPaper)
publication status
published
subject
keyword
POLYCHLORINATED-BIPHENYLS, REPORTER GENE ASSAYS, IN-VITRO, SEXUAL-MATURATION, ESTROGEN-RECEPTOR, ORGANOCHLORINE PESTICIDES, REPRODUCTIVE DEVELOPMENT, HORMONE CONCENTRATIONS, PRECOCIOUS PUBERTY, PRENATAL EXPOSURE
journal title
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Basic Clin. Pharmacol. Toxicol.
volume
102
issue
2
pages
168 - 175
conference name
International Conference on Foetal Programming and Development Toxicity
conference location
Torshavn, DENMARK
conference start
2007-05-20
conference end
2007-05-24
Web of Science type
Proceedings Paper
Web of Science id
000252588900016
JCR category
TOXICOLOGY
JCR impact factor
2.073 (2008)
JCR rank
43/74 (2008)
JCR quartile
3 (2008)
ISSN
1742-7835
DOI
10.1111/j.1742-7843.2007.00180.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
391408
handle
http://hdl.handle.net/1854/LU-391408
date created
2008-03-05 14:47:00
date last changed
2011-09-23 16:22:46
@article{391408,
  abstract     = {Onset and development of puberty is regulated by the neuroendocrine system. Population-based studies worldwide have observed secular trends towards earlier puberty development. These changes are apparently caused by environmental factors such as improved socio-economic status, improved health care and nutrition. However, they may also partly result from endocrine-disrupting chemicals in the environment. Epidemiological studies have investigated the relationship between pubertal development and exposure to endocrine-disrupting chemicals (polychlorinated biphenyls, polybrominated biphenyls, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane, phthalate esters, furans and the pesticide endosulfan). Associations with both perinatal and postnatal exposure have been reported. Studies in experimental animals support some of these findings and point to differential endocrine regulatory mechanisms linked to pubertal development acting in the perinatal and the pre-pubertal period. Pubertal development is naturally associated with growth and body composition. There is increasing evidence for a link between prenatal development and pubertal onset. In girls born small for gestational age (SGA), pubertal onset and age at menarche often are advanced, especially if there has been an extensive catch-up growth during the first months of life. In utero growth retardation may have multiple causes including exposure to xenobiotic substances as was suggested for some endocrine-disrupting chemicals. An abnormal perinatal environment of children born SGA may alter the endocrine status and the sensitivity of the receptors for endocrine and metabolic signalling that may have effects on maturation of brain and gonads. However, the causal pathways and the molecular mechanisms that may link the pubertal growth pattern of children born SGA, pubertal development and endocrine-disrupting chemicals need further study.},
  author       = {Schoeters, Greet and Den Hond, Elly and Dhooge, Willem and Van Larebeke, Nicolas and Leijs, Marike},
  issn         = {1742-7835},
  journal      = {BASIC \& CLINICAL PHARMACOLOGY \& TOXICOLOGY},
  keyword      = {POLYCHLORINATED-BIPHENYLS,REPORTER GENE ASSAYS,IN-VITRO,SEXUAL-MATURATION,ESTROGEN-RECEPTOR,ORGANOCHLORINE PESTICIDES,REPRODUCTIVE DEVELOPMENT,HORMONE CONCENTRATIONS,PRECOCIOUS PUBERTY,PRENATAL EXPOSURE},
  language     = {eng},
  location     = {Torshavn, DENMARK},
  number       = {2},
  pages        = {168--175},
  title        = {Endocrine disruptors and abnormalities of pubertal development},
  url          = {http://dx.doi.org/10.1111/j.1742-7843.2007.00180.x},
  volume       = {102},
  year         = {2008},
}

Chicago
Schoeters, Greet, Elly Den Hond, Willem Dhooge, Nicolas Van Larebeke, and Marike Leijs. 2008. “Endocrine Disruptors and Abnormalities of Pubertal Development.” Basic & Clinical Pharmacology & Toxicology 102 (2): 168–175.
APA
Schoeters, Greet, Den Hond, E., Dhooge, W., Van Larebeke, N., & Leijs, M. (2008). Endocrine disruptors and abnormalities of pubertal development. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 102(2), 168–175. Presented at the International Conference on Foetal Programming and Development Toxicity.
Vancouver
1.
Schoeters G, Den Hond E, Dhooge W, Van Larebeke N, Leijs M. Endocrine disruptors and abnormalities of pubertal development. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2008;102(2):168–75.
MLA
Schoeters, Greet, Elly Den Hond, Willem Dhooge, et al. “Endocrine Disruptors and Abnormalities of Pubertal Development.” BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 102.2 (2008): 168–175. Print.