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Detection of DNA copy number alterations in cancer by array comparative genomic hybridization

Evi Michels (UGent) , Katleen De Preter (UGent) , Nadine Van Roy (UGent) and Franki Speleman (UGent)
(2007) GENETICS IN MEDICINE. 9(9). p.574-584
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Abstract
Over the past few years, various reliable platforms for high-resolution detection of DNA copy number changes have become widely available. Together with optimized protocols for labeling and hybridization and algorithms for data analysis and representation, this has lead to a rapid increase in the application of this technology in the study of copy number variation in the human genome in normal cells and copy number imbalances in genetic diseases, including cancer. In this review, we briefly discuss specific technical issues relevant for array comparative genomic hybridization analysis in cancer tissues. We specifically focus on recent successes of array comparative genomic hybridization technology in the progress of our understanding of oncogenesis in a variety of cancer types. A third section highlights the potential of sensitive genome-wide detection of patterns of DNA imbalances or molecular portraits for class discovery and therapeutic stratification.
Keywords
array CGH, cancer, genomics, copy number alteration, microarray, prognosis, therapy, ACUTE LYMPHOBLASTIC-LEUKEMIA, TUMOR-SUPPRESSOR GENE, NUCLEOTIDE POLYMORPHISM ARRAYS, HIGH-RESOLUTION ANALYSIS, ACUTE MYELOID-LEUKEMIA, ROLLING-CIRCLE AMPLIFICATION, MANTLE-CELL LYMPHOMA, HUMAN BREAST-CANCER, HOMOZYGOUS DELETIONS, LUNG-CANCER

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Citation

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Chicago
Michels, Evi, Katleen De Preter, Nadine Van Roy, and Franki Speleman. 2007. “Detection of DNA Copy Number Alterations in Cancer by Array Comparative Genomic Hybridization.” Genetics in Medicine 9 (9): 574–584.
APA
Michels, E., De Preter, K., Van Roy, N., & Speleman, F. (2007). Detection of DNA copy number alterations in cancer by array comparative genomic hybridization. GENETICS IN MEDICINE, 9(9), 574–584.
Vancouver
1.
Michels E, De Preter K, Van Roy N, Speleman F. Detection of DNA copy number alterations in cancer by array comparative genomic hybridization. GENETICS IN MEDICINE. 2007;9(9):574–84.
MLA
Michels, Evi, Katleen De Preter, Nadine Van Roy, et al. “Detection of DNA Copy Number Alterations in Cancer by Array Comparative Genomic Hybridization.” GENETICS IN MEDICINE 9.9 (2007): 574–584. Print.
@article{388822,
  abstract     = {Over the past few years, various reliable platforms for high-resolution detection of DNA copy number changes have become widely available. Together with optimized protocols for labeling and hybridization and algorithms for data analysis and representation, this has lead to a rapid increase in the application of this technology in the study of copy number variation in the human genome in normal cells and copy number imbalances in genetic diseases, including cancer. In this review, we briefly discuss specific technical issues relevant for array comparative genomic hybridization analysis in cancer tissues. We specifically focus on recent successes of array comparative genomic hybridization technology in the progress of our understanding of oncogenesis in a variety of cancer types. A third section highlights the potential of sensitive genome-wide detection of patterns of DNA imbalances or molecular portraits for class discovery and therapeutic stratification.},
  author       = {Michels, Evi and De Preter, Katleen and Van Roy, Nadine and Speleman, Franki},
  issn         = {1098-3600},
  journal      = {GENETICS IN MEDICINE},
  keywords     = {array CGH,cancer,genomics,copy number alteration,microarray,prognosis,therapy,ACUTE LYMPHOBLASTIC-LEUKEMIA,TUMOR-SUPPRESSOR GENE,NUCLEOTIDE POLYMORPHISM ARRAYS,HIGH-RESOLUTION ANALYSIS,ACUTE MYELOID-LEUKEMIA,ROLLING-CIRCLE AMPLIFICATION,MANTLE-CELL LYMPHOMA,HUMAN BREAST-CANCER,HOMOZYGOUS DELETIONS,LUNG-CANCER},
  language     = {eng},
  number       = {9},
  pages        = {574--584},
  title        = {Detection of DNA copy number alterations in cancer by array comparative genomic hybridization},
  url          = {http://dx.doi.org/10.1097/GIM.0b013e318145b25b},
  volume       = {9},
  year         = {2007},
}

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