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Umbilical cord anomalies are more frequent in twins after assisted reproduction

(2007) HUMAN REPRODUCTION. 22(10). p.2763-2767
Author
Organization
Abstract
Background: The objective of this study is to analyse differences in cord characteristics between naturally conceived twins and twins born after assisted reproduction. Methods: Between 1985 and 2004, the East Flanders Prospective Twin Survey (EFPTS) registered 4159 twin pairs. We compared cord characteristics between 2119 naturally conceived dizygotic (DZ) twin members and 2243 DZ twin members originating from assisted reproductive technologies (ART). Data were adjusted for intra-twin correlation, year of birth, maternal age, gestational age, parity, sex of the child and number of placentas. Results: Marginal cord insertion, velamentous cord insertion and single umbilical artery (SUA) occur more frequently in twins following infertility treatment (P < 0.001). The incidence of velamentous cord insertion increases proportionate with 'invasiveness' of reproductive techniques: 3.6% in naturally conceived twins versus 5% in twins after artificial induction of ovulation (AIO) [ odds ratio (OR) 1.45; 95% confidence interval (CI) 0.99-2.11], 7.4% in twins after IVF (OR 1.49; 95% CI 1.26-1.77) and 10.4% in twins after ICSI (OR 1.31; 95% CI 1.14-1.51). SUA has the highest incidence in twins after AIO: 1.9% compared with 0.6% in naturally conceived twins (OR 3.19; 95% CI 1.66-6.11). Conclusions: Umbilical cords of twins born after ART have more pathologic characteristics when compared with cords of naturally conceived twins.
Keywords
INSERTION, CHILDREN BORN, BIRTH, COHORT, PLACENTAS, ARTERY, SINGLETON PREGNANCIES, EMBRYO-TRANSFER, IN-VITRO FERTILIZATION, multiple pregnancy, implantation, umbilical cord, assisted reproduction

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Citation

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MLA
Delbaere, Ilse, Sylvie Goetgeluk, Catherine Derom, et al. “Umbilical Cord Anomalies Are More Frequent in Twins After Assisted Reproduction.” HUMAN REPRODUCTION 22.10 (2007): 2763–2767. Print.
APA
Delbaere, I., Goetgeluk, S., Derom, C., De Bacquer, D., De Sutter, P., & Temmerman, M. (2007). Umbilical cord anomalies are more frequent in twins after assisted reproduction. HUMAN REPRODUCTION, 22(10), 2763–2767.
Chicago author-date
Delbaere, Ilse, Sylvie Goetgeluk, Catherine Derom, Dirk De Bacquer, Petra De Sutter, and Marleen Temmerman. 2007. “Umbilical Cord Anomalies Are More Frequent in Twins After Assisted Reproduction.” Human Reproduction 22 (10): 2763–2767.
Chicago author-date (all authors)
Delbaere, Ilse, Sylvie Goetgeluk, Catherine Derom, Dirk De Bacquer, Petra De Sutter, and Marleen Temmerman. 2007. “Umbilical Cord Anomalies Are More Frequent in Twins After Assisted Reproduction.” Human Reproduction 22 (10): 2763–2767.
Vancouver
1.
Delbaere I, Goetgeluk S, Derom C, De Bacquer D, De Sutter P, Temmerman M. Umbilical cord anomalies are more frequent in twins after assisted reproduction. HUMAN REPRODUCTION. 2007;22(10):2763–7.
IEEE
[1]
I. Delbaere, S. Goetgeluk, C. Derom, D. De Bacquer, P. De Sutter, and M. Temmerman, “Umbilical cord anomalies are more frequent in twins after assisted reproduction,” HUMAN REPRODUCTION, vol. 22, no. 10, pp. 2763–2767, 2007.
@article{384603,
  abstract     = {Background: The objective of this study is to analyse differences in cord characteristics between naturally conceived twins and twins born after assisted reproduction.
Methods: Between 1985 and 2004, the East Flanders Prospective Twin Survey (EFPTS) registered 4159 twin pairs. We compared cord characteristics between 2119 naturally conceived dizygotic (DZ) twin members and 2243 DZ twin members originating from assisted reproductive technologies (ART). Data were adjusted for intra-twin correlation, year of birth, maternal age, gestational age, parity, sex of the child and number of placentas.
Results: Marginal cord insertion, velamentous cord insertion and single umbilical artery (SUA) occur more frequently in twins following infertility treatment (P < 0.001). The incidence of velamentous cord insertion increases proportionate with 'invasiveness' of reproductive techniques: 3.6% in naturally conceived twins versus 5% in twins after artificial induction of ovulation (AIO) [ odds ratio (OR) 1.45; 95% confidence interval (CI) 0.99-2.11], 7.4% in twins after IVF (OR 1.49; 95% CI 1.26-1.77) and 10.4% in twins after ICSI (OR 1.31; 95% CI 1.14-1.51). SUA has the highest incidence in twins after AIO: 1.9% compared with 0.6% in naturally conceived twins (OR 3.19; 95% CI 1.66-6.11).
Conclusions: Umbilical cords of twins born after ART have more pathologic characteristics when compared with cords of naturally conceived twins.},
  author       = {Delbaere, Ilse and Goetgeluk, Sylvie and Derom, Catherine and De Bacquer, Dirk and De Sutter, Petra and Temmerman, Marleen},
  issn         = {0268-1161},
  journal      = {HUMAN REPRODUCTION},
  keywords     = {INSERTION,CHILDREN BORN,BIRTH,COHORT,PLACENTAS,ARTERY,SINGLETON PREGNANCIES,EMBRYO-TRANSFER,IN-VITRO FERTILIZATION,multiple pregnancy,implantation,umbilical cord,assisted reproduction},
  language     = {eng},
  number       = {10},
  pages        = {2763--2767},
  title        = {Umbilical cord anomalies are more frequent in twins after assisted reproduction},
  url          = {http://dx.doi.org/10.1093/humrep/dem191},
  volume       = {22},
  year         = {2007},
}

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