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Are metacaspases caspases?

Dominique Vercammen UGent, Wim Declercq UGent, Peter Vandenabeele UGent and Frank Van Breusegem UGent (2007) JOURNAL OF CELL BIOLOGY. 179(3). p.375-380
abstract
The identification of caspases as major regulators of apoptotic cell death in animals initiated a quest for homologous peptidases in other kingdoms. With the discovery of metacaspases in plants, fungi, and protozoa, this search had apparently reached its goal. However, there is compelling evidence that metacaspases lack caspase activity and that they are not responsible for the caspaselike activities detected during plant and fungal cell death. In this paper, we attempt to broaden the discussion of these peptidases to biological functions beyond apoptosis and cell death. We further suggest that metacaspases and paracaspases, although sharing structural and mechanistic features with the metazoan caspases, form a distinct family of clan CD cysteine peptidases.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
CLASSIFICATION, PROGRAMMED CELL-DEATH, ORIGIN, FAMILIES, PROTEASES, DICTYOSTELIUM, ARABIDOPSIS-THALIANA, SACCHAROMYCES-CEREVISIAE, APOPTOSIS, YEAST
journal title
JOURNAL OF CELL BIOLOGY
J. Cell Biol.
volume
179
issue
3
pages
375 - 380
Web of Science type
Review
Web of Science id
000250705200004
JCR category
CELL BIOLOGY
JCR impact factor
9.598 (2007)
JCR rank
17/151 (2007)
JCR quartile
1 (2007)
ISSN
0021-9525
DOI
10.1083/jcb.200705193
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
383717
handle
http://hdl.handle.net/1854/LU-383717
date created
2007-12-17 16:50:00
date last changed
2013-10-18 15:10:07
@article{383717,
  abstract     = {The identification of caspases as major regulators of apoptotic cell death in animals initiated a quest for homologous peptidases in other kingdoms. With the discovery of metacaspases in plants, fungi, and protozoa, this search had apparently reached its goal. However, there is compelling evidence that metacaspases lack caspase activity and that they are not responsible for the caspaselike activities detected during plant and fungal cell death. In this paper, we attempt to broaden the discussion of these peptidases to biological functions beyond apoptosis and cell death. We further suggest that metacaspases and paracaspases, although sharing structural and mechanistic features with the metazoan caspases, form a distinct family of clan CD cysteine peptidases.},
  author       = {Vercammen, Dominique and Declercq, Wim and Vandenabeele, Peter and Van Breusegem, Frank},
  issn         = {0021-9525},
  journal      = {JOURNAL OF CELL BIOLOGY},
  keyword      = {CLASSIFICATION,PROGRAMMED CELL-DEATH,ORIGIN,FAMILIES,PROTEASES,DICTYOSTELIUM,ARABIDOPSIS-THALIANA,SACCHAROMYCES-CEREVISIAE,APOPTOSIS,YEAST},
  language     = {eng},
  number       = {3},
  pages        = {375--380},
  title        = {Are metacaspases caspases?},
  url          = {http://dx.doi.org/10.1083/jcb.200705193},
  volume       = {179},
  year         = {2007},
}

Chicago
Vercammen, Dominique, Wim Declercq, Peter Vandenabeele, and Frank Van Breusegem. 2007. “Are Metacaspases Caspases?” Journal of Cell Biology 179 (3): 375–380.
APA
Vercammen, D., Declercq, W., Vandenabeele, P., & Van Breusegem, F. (2007). Are metacaspases caspases? JOURNAL OF CELL BIOLOGY, 179(3), 375–380.
Vancouver
1.
Vercammen D, Declercq W, Vandenabeele P, Van Breusegem F. Are metacaspases caspases? JOURNAL OF CELL BIOLOGY. 2007;179(3):375–80.
MLA
Vercammen, Dominique, Wim Declercq, Peter Vandenabeele, et al. “Are Metacaspases Caspases?” JOURNAL OF CELL BIOLOGY 179.3 (2007): 375–380. Print.