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Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease

Sofie Bekaert UGent, Tim De Meyer UGent, Ernst Rietzschel UGent, Marc De Buyzere, Dirk De Bacquer UGent, Michel Langlois UGent, Patrick Segers UGent, Luc Cooman, Piet Van Damme, Peter Cassiman, et al. (2007) AGING CELL. 6(5). p.639-647
abstract
Evidence assembled over the last decade shows that average telomere length (TL) acts as a biomarker for biological aging and cardiovascular disease (CVD) in particular. Although essential for a more profound understanding of the underlying mechanisms, little reference information is available on TL. We therefore sought to provide baseline TL information and assess the association of prevalent CVD risk factors with TL in subjects free of overt CVD within a small age range. We measured mean telomere restriction fragment length of peripheral blood leukocytes in a large, representative Asklepios study cohort of 2509 community-dwelling, Caucasian female and male volunteers aged approximately 35-55 years and free of overt CVD. We found a manifest age-dependent telomere attrition, at a significantly faster rate in men as compared to women. No significant associations were established with classical CVD risk factors such as cholesterol status and blood pressure, yet shorter TL was associated with increased levels of several inflammation and oxidative stress markers. Importantly, shorter telomere length was associated with an increasingly unhealthy lifestyle, particularly in men. All findings were age and gender adjusted where appropriate. With these cross-sectional results we show that TL of peripheral blood leukocytes primarily reflects the burden of increased oxidative stress and inflammation, whether or not determined by an increasingly unhealthy lifestyle, while the association with classical CVD risk factors is limited. This further clarifies the added value of TL as a biomarker for biological aging and might improve our understanding of how TL is associated with CVD.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
aging, inflammation, oxidative stress, lifestyle, telomere, LOW-DENSITY-LIPOPROTEIN, cardiovascular disease, PULSE PRESSURE, OLDEST-OLD, STRESS, ASSOCIATION, CORONARY, HYPERTENSION, CHROMOSOME, SENESCENCE, INSULIN-RESISTANCE
journal title
AGING CELL
Aging Cell
volume
6
issue
5
pages
639 - 647
Web of Science type
Article
Web of Science id
000249479800006
JCR category
GERIATRICS & GERONTOLOGY
JCR impact factor
5.854 (2007)
JCR rank
2/31 (2007)
JCR quartile
1 (2007)
ISSN
1474-9718
DOI
10.1111/j.1474-9726.2007.00321.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
383293
handle
http://hdl.handle.net/1854/LU-383293
date created
2007-12-06 15:09:00
date last changed
2016-12-19 15:43:27
@article{383293,
  abstract     = {Evidence assembled over the last decade shows that average telomere length (TL) acts as a biomarker for biological aging and cardiovascular disease (CVD) in particular. Although essential for a more profound understanding of the underlying mechanisms, little reference information is available on TL. We therefore sought to provide baseline TL information and assess the association of prevalent CVD risk factors with TL in subjects free of overt CVD within a small age range. We measured mean telomere restriction fragment length of peripheral blood leukocytes in a large, representative Asklepios study cohort of 2509 community-dwelling, Caucasian female and male volunteers aged approximately 35-55 years and free of overt CVD. We found a manifest age-dependent telomere attrition, at a significantly faster rate in men as compared to women. No significant associations were established with classical CVD risk factors such as cholesterol status and blood pressure, yet shorter TL was associated with increased levels of several inflammation and oxidative stress markers. Importantly, shorter telomere length was associated with an increasingly unhealthy lifestyle, particularly in men. All findings were age and gender adjusted where appropriate. With these cross-sectional results we show that TL of peripheral blood leukocytes primarily reflects the burden of increased oxidative stress and inflammation, whether or not determined by an increasingly unhealthy lifestyle, while the association with classical CVD risk factors is limited. This further clarifies the added value of TL as a biomarker for biological aging and might improve our understanding of how TL is associated with CVD.},
  author       = {Bekaert, Sofie and De Meyer, Tim and Rietzschel, Ernst and De Buyzere, Marc and De Bacquer, Dirk and Langlois, Michel and Segers, Patrick and Cooman, Luc and Van Damme, Piet and Cassiman, Peter and Van Criekinge, Wim and Verdonck, Pascal and De Backer, Gui and Gillebert, Thierry and Van Oostveldt, Patric},
  issn         = {1474-9718},
  journal      = {AGING CELL},
  keyword      = {aging,inflammation,oxidative stress,lifestyle,telomere,LOW-DENSITY-LIPOPROTEIN,cardiovascular disease,PULSE PRESSURE,OLDEST-OLD,STRESS,ASSOCIATION,CORONARY,HYPERTENSION,CHROMOSOME,SENESCENCE,INSULIN-RESISTANCE},
  language     = {eng},
  number       = {5},
  pages        = {639--647},
  title        = {Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease},
  url          = {http://dx.doi.org/10.1111/j.1474-9726.2007.00321.x},
  volume       = {6},
  year         = {2007},
}

Chicago
Bekaert, Sofie, Tim De Meyer, Ernst Rietzschel, MARC DE BUYZERE, Dirk De Bacquer, Michel Langlois, Patrick Segers, et al. 2007. “Telomere Length and Cardiovascular Risk Factors in a Middle-aged Population Free of Overt Cardiovascular Disease.” Aging Cell 6 (5): 639–647.
APA
Bekaert, Sofie, De Meyer, T., Rietzschel, E., DE BUYZERE, M., De Bacquer, D., Langlois, M., Segers, P., et al. (2007). Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. AGING CELL, 6(5), 639–647.
Vancouver
1.
Bekaert S, De Meyer T, Rietzschel E, DE BUYZERE M, De Bacquer D, Langlois M, et al. Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. AGING CELL. 2007;6(5):639–47.
MLA
Bekaert, Sofie, Tim De Meyer, Ernst Rietzschel, et al. “Telomere Length and Cardiovascular Risk Factors in a Middle-aged Population Free of Overt Cardiovascular Disease.” AGING CELL 6.5 (2007): 639–647. Print.