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Use of [I-121]-2-iodo-L-phenylalanine as a tumor imaging agent in two dogs with synovial cell sarcoma

Kathelijne Peremans UGent, Veerle Kersemans, Tiziana Liuti, Eva Vandermeulen UGent, Bart Cornelissen, Ingrid Gielen UGent, Bart De Spiegeleer UGent, J MERTENS, Christian Burvenich UGent and Guido Slegers UGent (2007) VETERINARY RADIOLOGY & ULTRASOUND. 48(5). p.471-474
abstract
[I-123]-iodo-L-phenylalanine was successfully evaluated for gamma camera imaging in vivo in tumor-bearing athymic mice and in humans with brain tumors. Here, we report the use of this tracer in two dogs with synovial cell sarcoma of the tarsus. [I-123]-iodo-L-phenylalanine was quantitatively prepared as a kit formulation using the Cu1+-assisted nucleophilic exchange. Rapid [I-123]-2-iodo-L-phenylalanine tumor accumulation was observed with good tumor to background contrast and rapid clearance in these two dogs. This radiopharmaceutical is a promising alternative tumor tracer to overcome the known limitations of F-18-fluorodeoxyglucose and, when labelled with radioiodine-131, has the potential to be used for therapeutic purposes.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
TRACER, DIAGNOSIS, THERAPY, PHEOCHROMOCYTOMA, TRANSPORT, DOSIMETRY, ONCOLOGY, [I-123]-2-iodo-L-phenylaianine, dogs, gamma camera imaging, synovial carcinoma, tumor diagnosticum, ATHYMIC MOUSE MODEL, AMINO-ACID, SPECT
journal title
VETERINARY RADIOLOGY & ULTRASOUND
Vet. Radiol. Ultrasound
volume
48
issue
5
pages
471-474 pages
publisher
BLACKWELL PUBLISHING
Web of Science type
Article
Web of Science id
000249288600015
JCR category
VETERINARY SCIENCES
JCR impact factor
1.053 (2007)
JCR rank
39/122 (2007)
JCR quartile
2 (2007)
ISSN
1058-8183
DOI
10.1111/j.1740-8261.2007.00281.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
382561
handle
http://hdl.handle.net/1854/LU-382561
date created
2007-11-24 13:41:00
date last changed
2010-06-23 09:39:29
@article{382561,
  abstract     = {[I-123]-iodo-L-phenylalanine was successfully evaluated for gamma camera imaging in vivo in tumor-bearing athymic mice and in humans with brain tumors. Here, we report the use of this tracer in two dogs with synovial cell sarcoma of the tarsus. [I-123]-iodo-L-phenylalanine was quantitatively prepared as a kit formulation using the Cu1+-assisted nucleophilic exchange. Rapid [I-123]-2-iodo-L-phenylalanine tumor accumulation was observed with good tumor to background contrast and rapid clearance in these two dogs. This radiopharmaceutical is a promising alternative tumor tracer to overcome the known limitations of F-18-fluorodeoxyglucose and, when labelled with radioiodine-131, has the potential to be used for therapeutic purposes.},
  author       = {Peremans, Kathelijne and Kersemans, Veerle and Liuti, Tiziana and Vandermeulen, Eva and Cornelissen, Bart and Gielen, Ingrid and De Spiegeleer, Bart and MERTENS, J and Burvenich, Christian and Slegers, Guido},
  issn         = {1058-8183},
  journal      = {VETERINARY RADIOLOGY \& ULTRASOUND},
  keyword      = {TRACER,DIAGNOSIS,THERAPY,PHEOCHROMOCYTOMA,TRANSPORT,DOSIMETRY,ONCOLOGY,[I-123]-2-iodo-L-phenylaianine,dogs,gamma camera imaging,synovial carcinoma,tumor diagnosticum,ATHYMIC MOUSE MODEL,AMINO-ACID,SPECT},
  language     = {eng},
  number       = {5},
  pages        = {471--474},
  publisher    = {BLACKWELL PUBLISHING},
  title        = {Use of [I-121]-2-iodo-L-phenylalanine as a tumor imaging agent in two dogs with synovial cell sarcoma},
  url          = {http://dx.doi.org/10.1111/j.1740-8261.2007.00281.x},
  volume       = {48},
  year         = {2007},
}

Chicago
Peremans, Kathelijne, Veerle Kersemans, Tiziana Liuti, Eva Vandermeulen, Bart Cornelissen, Ingrid Gielen, Bart De Spiegeleer, J MERTENS, Christian Burvenich, and Guido Slegers. 2007. “Use of [I-121]-2-iodo-L-phenylalanine as a Tumor Imaging Agent in Two Dogs with Synovial Cell Sarcoma.” Veterinary Radiology & Ultrasound 48 (5): 471–474.
APA
Peremans, K., Kersemans, V., Liuti, T., Vandermeulen, E., Cornelissen, B., Gielen, I., De Spiegeleer, B., et al. (2007). Use of [I-121]-2-iodo-L-phenylalanine as a tumor imaging agent in two dogs with synovial cell sarcoma. VETERINARY RADIOLOGY & ULTRASOUND, 48(5), 471–474.
Vancouver
1.
Peremans K, Kersemans V, Liuti T, Vandermeulen E, Cornelissen B, Gielen I, et al. Use of [I-121]-2-iodo-L-phenylalanine as a tumor imaging agent in two dogs with synovial cell sarcoma. VETERINARY RADIOLOGY & ULTRASOUND. BLACKWELL PUBLISHING; 2007;48(5):471–4.
MLA
Peremans, Kathelijne, Veerle Kersemans, Tiziana Liuti, et al. “Use of [I-121]-2-iodo-L-phenylalanine as a Tumor Imaging Agent in Two Dogs with Synovial Cell Sarcoma.” VETERINARY RADIOLOGY & ULTRASOUND 48.5 (2007): 471–474. Print.