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The protective properties of vaccination against equine herpesvirus 1-induced viremia, abortion and nervous system disorders

Karen van der Meulen UGent, Annick Gryspeerdt UGent, Annelies Vandekerckhove UGent, Barbara Garré and Hans Nauwynck UGent (2007) VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 76(3). p.186-194
abstract
Equine herpesvirus (EHV) 1 is an important pathogen of horses. Upon infection, the virus replicates in the upper respiratory tract. Then it spreads to internal organs via a cell-associated viremia. Local replication in internal organs may result in abortion and nervous system disorders. The currently designed vaccines are not able to induce significant protection against EHV1-induced viremia. However, several vaccines are able to induce a significant level of protection against either abortion or nervous system disorders. Which immune responses correlate with this protection is so far unknown. Besides vaccination, management will remain a crucial factor in the prevention of EHV1-induced clinical signs. Management measures include the vaccination of all horses on the premises to reduce infection pressure; the separate housing of young horses, adult horses and pregnant mares; strict hygiene measures and strict control of contact with horses from outside the premises. If, despite vaccination and thorough management, an outbreak of EHV1-induced disease occurs, treatment with antiviral agents may be useful.
Please use this url to cite or link to this publication:
author
organization
alternative title
Het beschermend ef fect van vaccinatie tegen equiene herpesvirus 1-geïnduceerde viremie, abortus en zenuwstoornissen
year
type
journalArticle (review)
publication status
published
subject
keyword
PATHOGEN-FREE FOALS, ENDOTHELIAL-CELL INFECTION, GLYCOPROTEIN-D, MURINE MODEL, EXPERIMENTAL CHALLENGE, RESPIRATORY-TRACT, DELETION MUTANT, TYPE-1 EHV-1, YOUNG HORSES, ADULT HORSES
journal title
VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
Vlaams Diergeneesk. Tijdschr.
volume
76
issue
3
pages
186 - 194
Web of Science type
Review
Web of Science id
000247464200002
JCR category
VETERINARY SCIENCES
JCR impact factor
0.121 (2007)
JCR rank
113/122 (2007)
JCR quartile
4 (2007)
ISSN
0303-9021
language
Dutch
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
378958
handle
http://hdl.handle.net/1854/LU-378958
alternative location
http://vdt.ugent.be/code/showupload.php?id=292
date created
2007-10-15 11:15:00
date last changed
2011-05-10 10:21:40
@article{378958,
  abstract     = {Equine herpesvirus (EHV) 1 is an important pathogen of horses. Upon infection, the virus replicates in the upper respiratory tract. Then it spreads to internal organs via a cell-associated viremia. Local replication in internal organs may result in abortion and nervous system disorders. The currently designed vaccines are not able to induce significant protection against EHV1-induced viremia. However, several vaccines are able to induce a significant level of protection against either abortion or nervous system disorders. Which immune responses correlate with this protection is so far unknown. Besides vaccination, management will remain a crucial factor in the prevention of EHV1-induced clinical signs. Management measures include the vaccination of all horses on the premises to reduce infection pressure; the separate housing of young horses, adult horses and pregnant mares; strict hygiene measures and strict control of contact with horses from outside the premises. If, despite vaccination and thorough management, an outbreak of EHV1-induced disease occurs, treatment with antiviral agents may be useful.},
  author       = {van der Meulen, Karen and Gryspeerdt, Annick and Vandekerckhove, Annelies and Garr{\'e}, Barbara and Nauwynck, Hans},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  keyword      = {PATHOGEN-FREE FOALS,ENDOTHELIAL-CELL INFECTION,GLYCOPROTEIN-D,MURINE MODEL,EXPERIMENTAL CHALLENGE,RESPIRATORY-TRACT,DELETION MUTANT,TYPE-1 EHV-1,YOUNG HORSES,ADULT HORSES},
  language     = {dut},
  number       = {3},
  pages        = {186--194},
  title        = {The protective properties of vaccination against equine herpesvirus 1-induced viremia, abortion and nervous system disorders},
  url          = {http://vdt.ugent.be/code/showupload.php?id=292},
  volume       = {76},
  year         = {2007},
}

Chicago
van der Meulen, Karen, Annick Gryspeerdt, Annelies Vandekerckhove, Barbara Garré, and Hans Nauwynck. 2007. “The Protective Properties of Vaccination Against Equine Herpesvirus 1-induced Viremia, Abortion and Nervous System Disorders.” Vlaams Diergeneeskundig Tijdschrift 76 (3): 186–194.
APA
van der Meulen, K., Gryspeerdt, A., Vandekerckhove, A., Garré, B., & Nauwynck, H. (2007). The protective properties of vaccination against equine herpesvirus 1-induced viremia, abortion and nervous system disorders. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 76(3), 186–194.
Vancouver
1.
van der Meulen K, Gryspeerdt A, Vandekerckhove A, Garré B, Nauwynck H. The protective properties of vaccination against equine herpesvirus 1-induced viremia, abortion and nervous system disorders. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2007;76(3):186–94.
MLA
van der Meulen, Karen, Annick Gryspeerdt, Annelies Vandekerckhove, et al. “The Protective Properties of Vaccination Against Equine Herpesvirus 1-induced Viremia, Abortion and Nervous System Disorders.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 76.3 (2007): 186–194. Print.