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The protective properties of vaccination against equine herpesvirus 1-induced viremia, abortion and nervous system disorders

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Abstract
Equine herpesvirus (EHV) 1 is an important pathogen of horses. Upon infection, the virus replicates in the upper respiratory tract. Then it spreads to internal organs via a cell-associated viremia. Local replication in internal organs may result in abortion and nervous system disorders. The currently designed vaccines are not able to induce significant protection against EHV1-induced viremia. However, several vaccines are able to induce a significant level of protection against either abortion or nervous system disorders. Which immune responses correlate with this protection is so far unknown. Besides vaccination, management will remain a crucial factor in the prevention of EHV1-induced clinical signs. Management measures include the vaccination of all horses on the premises to reduce infection pressure; the separate housing of young horses, adult horses and pregnant mares; strict hygiene measures and strict control of contact with horses from outside the premises. If, despite vaccination and thorough management, an outbreak of EHV1-induced disease occurs, treatment with antiviral agents may be useful.
Keywords
PATHOGEN-FREE FOALS, ENDOTHELIAL-CELL INFECTION, GLYCOPROTEIN-D, MURINE MODEL, EXPERIMENTAL CHALLENGE, RESPIRATORY-TRACT, DELETION MUTANT, TYPE-1 EHV-1, YOUNG HORSES, ADULT HORSES

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Citation

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MLA
van der Meulen, Karen, et al. “The Protective Properties of Vaccination against Equine Herpesvirus 1-Induced Viremia, Abortion and Nervous System Disorders.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, vol. 76, no. 3, 2007, pp. 186–94.
APA
van der Meulen, K., Gryspeerdt, A., Vandekerckhove, A., Garré, B., & Nauwynck, H. (2007). The protective properties of vaccination against equine herpesvirus 1-induced viremia, abortion and nervous system disorders. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 76(3), 186–194.
Chicago author-date
Meulen, Karen van der, Annick Gryspeerdt, Annelies Vandekerckhove, Barbara Garré, and Hans Nauwynck. 2007. “The Protective Properties of Vaccination against Equine Herpesvirus 1-Induced Viremia, Abortion and Nervous System Disorders.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 76 (3): 186–94.
Chicago author-date (all authors)
van der Meulen, Karen, Annick Gryspeerdt, Annelies Vandekerckhove, Barbara Garré, and Hans Nauwynck. 2007. “The Protective Properties of Vaccination against Equine Herpesvirus 1-Induced Viremia, Abortion and Nervous System Disorders.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 76 (3): 186–194.
Vancouver
1.
van der Meulen K, Gryspeerdt A, Vandekerckhove A, Garré B, Nauwynck H. The protective properties of vaccination against equine herpesvirus 1-induced viremia, abortion and nervous system disorders. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2007;76(3):186–94.
IEEE
[1]
K. van der Meulen, A. Gryspeerdt, A. Vandekerckhove, B. Garré, and H. Nauwynck, “The protective properties of vaccination against equine herpesvirus 1-induced viremia, abortion and nervous system disorders,” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, vol. 76, no. 3, pp. 186–194, 2007.
@article{378958,
  abstract     = {{Equine herpesvirus (EHV) 1 is an important pathogen of horses. Upon infection, the virus replicates in the upper respiratory tract. Then it spreads to internal organs via a cell-associated viremia. Local replication in internal organs may result in abortion and nervous system disorders. The currently designed vaccines are not able to induce significant protection against EHV1-induced viremia. However, several vaccines are able to induce a significant level of protection against either abortion or nervous system disorders. Which immune responses correlate with this protection is so far unknown. Besides vaccination, management will remain a crucial factor in the prevention of EHV1-induced clinical signs. Management measures include the vaccination of all horses on the premises to reduce infection pressure; the separate housing of young horses, adult horses and pregnant mares; strict hygiene measures and strict control of contact with horses from outside the premises. If, despite vaccination and thorough management, an outbreak of EHV1-induced disease occurs, treatment with antiviral agents may be useful.}},
  author       = {{van der Meulen, Karen and Gryspeerdt, Annick and Vandekerckhove, Annelies and Garré, Barbara and Nauwynck, Hans}},
  issn         = {{0303-9021}},
  journal      = {{VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT}},
  keywords     = {{PATHOGEN-FREE FOALS,ENDOTHELIAL-CELL INFECTION,GLYCOPROTEIN-D,MURINE MODEL,EXPERIMENTAL CHALLENGE,RESPIRATORY-TRACT,DELETION MUTANT,TYPE-1 EHV-1,YOUNG HORSES,ADULT HORSES}},
  language     = {{dut}},
  number       = {{3}},
  pages        = {{186--194}},
  title        = {{The protective properties of vaccination against equine herpesvirus 1-induced viremia, abortion and nervous system disorders}},
  url          = {{http://vdt.ugent.be/code/showupload.php?id=292}},
  volume       = {{76}},
  year         = {{2007}},
}

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