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Comparison of the wetting properties of three commonly used simulated intestinal fluids used as dissolution media in the characterization of drugs

Bart De Spiegeleer UGent, Bram Baert UGent, Elien Vangheluwe UGent, Ilse Becue UGent, Jan De Smet, Pieter Spanoghe UGent, Christophe Wille, Paul Van Der Meeren UGent and Guido Slegers UGent (2007) JOURNAL OF SOLUTION CHEMISTRY. 36(7). p.835-843
abstract
Simulated intestinal fluids (SIFs) are described in the United States Pharmacopoeia (USP) and the International Pharmacopoeia (IntPh) as recommended dissolution media for the characterization of solid drugs. This study was carried out to compare their wettability, properties. Six different model substrates were used as surrogates for solid drugs. These surrogate solid substrates were characterized by the Lifshitz-van der Waals, electron donor and electron acceptor terms, which are the three components of the total surface energy obtained by the van Oss model, which is based upon Young's equation. Contact angles of the SIFs on the surrogate solid-substrates were determined dynamically by image analysis up to five minutes after applying a drop of the fluid on the solid surface. Observed time-dependent spreading behavior was accounted for by a linear extrapolation of the experimental data to zero contact time to obtain the apparent equilibrium contact angle at zero time. Additionally, the pH, osmolality and buffer capacity of the SIFs were experimentally determined. Although some differences in osmolality and buffer capacity were observed, no statistically significant differences in the wetting properties of the three SIFs were detected. This confirms recent findings that there are no observed differences in dissolution behavior among these simulated intestinal fluids. Harmonization of these SIFs is thus recommended.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
dissolution, SURFACE FREE-ENERGY, drugs, surrogate solid-substrate, simulated intestinal fluids (SIFs), wettability, contact angle, CONTACT ANGLES, BEHAVIOR
journal title
JOURNAL OF SOLUTION CHEMISTRY
J. Solut. Chem.
volume
36
issue
7
pages
835-843 pages
Web of Science type
Article
Web of Science id
000247033200001
JCR category
CHEMISTRY, PHYSICAL
JCR impact factor
1.124 (2007)
JCR rank
73/107 (2007)
JCR quartile
3 (2007)
ISSN
0095-9782
DOI
10.1007/s10953-007-9150-5
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
374940
handle
http://hdl.handle.net/1854/LU-374940
date created
2007-08-04 14:47:00
date last changed
2009-10-23 14:38:26
@article{374940,
  abstract     = {Simulated intestinal fluids (SIFs) are described in the United States Pharmacopoeia (USP) and the International Pharmacopoeia (IntPh) as recommended dissolution media for the characterization of solid drugs. This study was carried out to compare their wettability, properties. Six different model substrates were used as surrogates for solid drugs. These surrogate solid substrates were characterized by the Lifshitz-van der Waals, electron donor and electron acceptor terms, which are the three components of the total surface energy obtained by the van Oss model, which is based upon Young's equation. Contact angles of the SIFs on the surrogate solid-substrates were determined dynamically by image analysis up to five minutes after applying a drop of the fluid on the solid surface. Observed time-dependent spreading behavior was accounted for by a linear extrapolation of the experimental data to zero contact time to obtain the apparent equilibrium contact angle at zero time. Additionally, the pH, osmolality and buffer capacity of the SIFs were experimentally determined. Although some differences in osmolality and buffer capacity were observed, no statistically significant differences in the wetting properties of the three SIFs were detected. This confirms recent findings that there are no observed differences in dissolution behavior among these simulated intestinal fluids. Harmonization of these SIFs is thus recommended.},
  author       = {De Spiegeleer, Bart and Baert, Bram and Vangheluwe, Elien and Becue, Ilse and De Smet, Jan and Spanoghe, Pieter and Wille, Christophe and Van Der Meeren, Paul and Slegers, Guido},
  issn         = {0095-9782},
  journal      = {JOURNAL OF SOLUTION CHEMISTRY},
  keyword      = {dissolution,SURFACE FREE-ENERGY,drugs,surrogate solid-substrate,simulated intestinal fluids (SIFs),wettability,contact angle,CONTACT ANGLES,BEHAVIOR},
  language     = {eng},
  number       = {7},
  pages        = {835--843},
  title        = {Comparison of the wetting properties of three commonly used simulated intestinal fluids used as dissolution media in the characterization of drugs},
  url          = {http://dx.doi.org/10.1007/s10953-007-9150-5},
  volume       = {36},
  year         = {2007},
}

Chicago
De Spiegeleer, Bart, Bram Baert, Elien Vangheluwe, Ilse Becue, Jan De Smet, Pieter Spanoghe, Christophe Wille, Paul Van Der Meeren, and Guido Slegers. 2007. “Comparison of the Wetting Properties of Three Commonly Used Simulated Intestinal Fluids Used as Dissolution Media in the Characterization of Drugs.” Journal of Solution Chemistry 36 (7): 835–843.
APA
De Spiegeleer, B., Baert, B., Vangheluwe, E., Becue, I., De Smet, J., Spanoghe, P., Wille, C., et al. (2007). Comparison of the wetting properties of three commonly used simulated intestinal fluids used as dissolution media in the characterization of drugs. JOURNAL OF SOLUTION CHEMISTRY, 36(7), 835–843.
Vancouver
1.
De Spiegeleer B, Baert B, Vangheluwe E, Becue I, De Smet J, Spanoghe P, et al. Comparison of the wetting properties of three commonly used simulated intestinal fluids used as dissolution media in the characterization of drugs. JOURNAL OF SOLUTION CHEMISTRY. 2007;36(7):835–43.
MLA
De Spiegeleer, Bart, Bram Baert, Elien Vangheluwe, et al. “Comparison of the Wetting Properties of Three Commonly Used Simulated Intestinal Fluids Used as Dissolution Media in the Characterization of Drugs.” JOURNAL OF SOLUTION CHEMISTRY 36.7 (2007): 835–843. Print.