- Author
- Tom Michoel (UGent) and Yves Van de Peer (UGent)
- Organization
- Abstract
- An inhomogeneous helicoidal nearest-neighbor model with continuous degrees of freedom is shown to predict the same DNA melting properties as traditional long-range Ising models, for free DNA molecules in solution, as well as superhelically stressed DNA with a fixed linking number constraint. Without loss of accuracy, the continuous degrees of freedom can be discretized using a minimal number of discretization points, yielding an effective transfer matrix model of modest dimension (d=36). The resulting algorithms to compute DNA melting profiles are both simple and efficient.
- Keywords
- DOUBLE-STRANDED DNA, PEYRARD-BISHOP MODEL, DUPLEX DESTABILIZATION, STATISTICAL-MECHANICS, SUPERHELICAL DNA, DENATURATION, MACROMOLECULES, MOLECULES, PROFILES, PHYSICS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-372288
- MLA
- Michoel, Tom, and Yves Van de Peer. “Helicoidal Transfer Matrix Model for Inhomogeneous DNA Melting.” PHYSICAL REVIEW E, vol. 73, no. 1, 2006, doi:10.1103/PhysRevE.73.011908.
- APA
- Michoel, T., & Van de Peer, Y. (2006). Helicoidal transfer matrix model for inhomogeneous DNA melting. PHYSICAL REVIEW E, 73(1). https://doi.org/10.1103/PhysRevE.73.011908
- Chicago author-date
- Michoel, Tom, and Yves Van de Peer. 2006. “Helicoidal Transfer Matrix Model for Inhomogeneous DNA Melting.” PHYSICAL REVIEW E 73 (1). https://doi.org/10.1103/PhysRevE.73.011908.
- Chicago author-date (all authors)
- Michoel, Tom, and Yves Van de Peer. 2006. “Helicoidal Transfer Matrix Model for Inhomogeneous DNA Melting.” PHYSICAL REVIEW E 73 (1). doi:10.1103/PhysRevE.73.011908.
- Vancouver
- 1.Michoel T, Van de Peer Y. Helicoidal transfer matrix model for inhomogeneous DNA melting. PHYSICAL REVIEW E. 2006;73(1).
- IEEE
- [1]T. Michoel and Y. Van de Peer, “Helicoidal transfer matrix model for inhomogeneous DNA melting,” PHYSICAL REVIEW E, vol. 73, no. 1, 2006.
@article{372288,
abstract = {{An inhomogeneous helicoidal nearest-neighbor model with continuous degrees of freedom is shown to predict the same DNA melting properties as traditional long-range Ising models, for free DNA molecules in solution, as well as superhelically stressed DNA with a fixed linking number constraint. Without loss of accuracy, the continuous degrees of freedom can be discretized using a minimal number of discretization points, yielding an effective transfer matrix model of modest dimension (d=36). The resulting algorithms to compute DNA melting profiles are both simple and efficient.}},
articleno = {{011908}},
author = {{Michoel, Tom and Van de Peer, Yves}},
issn = {{1539-3755}},
journal = {{PHYSICAL REVIEW E}},
keywords = {{DOUBLE-STRANDED DNA,PEYRARD-BISHOP MODEL,DUPLEX DESTABILIZATION,STATISTICAL-MECHANICS,SUPERHELICAL DNA,DENATURATION,MACROMOLECULES,MOLECULES,PROFILES,PHYSICS}},
language = {{eng}},
number = {{1}},
pages = {{11}},
title = {{Helicoidal transfer matrix model for inhomogeneous DNA melting}},
url = {{http://dx.doi.org/10.1103/PhysRevE.73.011908}},
volume = {{73}},
year = {{2006}},
}
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