Cyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison
(2006) CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 41(5). p.293-313- abstract
- The cell cycle is remarkably conserved in yeast, animals, and plants and is controlled by cyclin-dependent kinases (CDKs). CDK activity can be inhibited by binding of CDK inhibitory proteins, designated CKIs. Numerous studies show that CKIs are essential in orchestrating eukaryotic cell proliferation and differentiation. In yeast, animals, and plants, CKIs act as regulators of the G1 checkpoint in response to environmental and developmental cues and assist during mitotic cell cycles by inhibiting CDK activity required to arrest mitosis. Furthermore, CKIs play an important role in regulating cell cycle exit that precedes differentiation and in promoting differentiation in cooperation with transcription factors. Moreover, CKIs are essential to control CDK activity in endocycling cells. So, in yeast, animals, and plants, CKIs share many functional similarities, but their functions are adapted toward the specific needs of the eukaryote.
Please use this url to cite or link to this publication:
http://hdl.handle.net/1854/LU-371526
- author
- Annelies De Clercq UGent and Dirk Inzé UGent
- organization
- year
- 2006
- type
- journalArticle (review)
- publication status
- published
- subject
- keyword
- CAENORHABDITIS-ELEGANS, ARABIDOPSIS-THALIANA, PROTEIN-KINASE, G1 CYCLIN, SACCHAROMYCES-CEREVISIAE, CDK-INHIBITOR, CELL NUCLEAR ANTIGEN, TUMOR-SUPPRESSOR GENE, B-TYPE CYCLIN, GENOME-WIDE ANALYSIS, differentiation, proliferation, checkpoint, CKI, cell cycle
- journal title
- CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Crit. Rev. Biochem. Mol. Biol.
- volume
- 41
- issue
- 5
- pages
- 293 - 313
- Web of Science type
- Review
- Web of Science id
- 000239768300002
- JCR category
- BIOCHEMISTRY & MOLECULAR BIOLOGY
- JCR impact factor
- 9.393 (2006)
- JCR rank
- 18/259 (2006)
- JCR quartile
- 1 (2006)
- ISSN
- 1040-9238
- DOI
- 10.1080/10409230600856685
- language
- English
- UGent publication?
- yes
- classification
- A1
- copyright statement
- I have transferred the copyright for this publication to the publisher
- id
- 371526
- handle
- http://hdl.handle.net/1854/LU-371526
- date created
- 2007-07-03 15:50:00
- date last changed
- 2016-12-19 15:45:09
@article{371526, abstract = {The cell cycle is remarkably conserved in yeast, animals, and plants and is controlled by cyclin-dependent kinases (CDKs). CDK activity can be inhibited by binding of CDK inhibitory proteins, designated CKIs. Numerous studies show that CKIs are essential in orchestrating eukaryotic cell proliferation and differentiation. In yeast, animals, and plants, CKIs act as regulators of the G1 checkpoint in response to environmental and developmental cues and assist during mitotic cell cycles by inhibiting CDK activity required to arrest mitosis. Furthermore, CKIs play an important role in regulating cell cycle exit that precedes differentiation and in promoting differentiation in cooperation with transcription factors. Moreover, CKIs are essential to control CDK activity in endocycling cells. So, in yeast, animals, and plants, CKIs share many functional similarities, but their functions are adapted toward the specific needs of the eukaryote.}, author = {De Clercq, Annelies and Inz{\'e}, Dirk}, issn = {1040-9238}, journal = {CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY}, keyword = {CAENORHABDITIS-ELEGANS,ARABIDOPSIS-THALIANA,PROTEIN-KINASE,G1 CYCLIN,SACCHAROMYCES-CEREVISIAE,CDK-INHIBITOR,CELL NUCLEAR ANTIGEN,TUMOR-SUPPRESSOR GENE,B-TYPE CYCLIN,GENOME-WIDE ANALYSIS,differentiation,proliferation,checkpoint,CKI,cell cycle}, language = {eng}, number = {5}, pages = {293--313}, title = {Cyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison}, url = {http://dx.doi.org/10.1080/10409230600856685}, volume = {41}, year = {2006}, }
- Chicago
- De Clercq, Annelies, and Dirk Inzé. 2006. “Cyclin-dependent Kinase Inhibitors in Yeast, Animals, and Plants: a Functional Comparison.” Critical Reviews in Biochemistry and Molecular Biology 41 (5): 293–313.
- APA
- De Clercq, Annelies, & Inzé, D. (2006). Cyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 41(5), 293–313.
- Vancouver
- 1.De Clercq A, Inzé D. Cyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2006;41(5):293–313.
- MLA
- De Clercq, Annelies, and Dirk Inzé. “Cyclin-dependent Kinase Inhibitors in Yeast, Animals, and Plants: a Functional Comparison.” CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 41.5 (2006): 293–313. Print.