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Cyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison

Annelies De Clercq (UGent) and Dirk Inzé (UGent)
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Abstract
The cell cycle is remarkably conserved in yeast, animals, and plants and is controlled by cyclin-dependent kinases (CDKs). CDK activity can be inhibited by binding of CDK inhibitory proteins, designated CKIs. Numerous studies show that CKIs are essential in orchestrating eukaryotic cell proliferation and differentiation. In yeast, animals, and plants, CKIs act as regulators of the G1 checkpoint in response to environmental and developmental cues and assist during mitotic cell cycles by inhibiting CDK activity required to arrest mitosis. Furthermore, CKIs play an important role in regulating cell cycle exit that precedes differentiation and in promoting differentiation in cooperation with transcription factors. Moreover, CKIs are essential to control CDK activity in endocycling cells. So, in yeast, animals, and plants, CKIs share many functional similarities, but their functions are adapted toward the specific needs of the eukaryote.
Keywords
CAENORHABDITIS-ELEGANS, ARABIDOPSIS-THALIANA, PROTEIN-KINASE, G1 CYCLIN, SACCHAROMYCES-CEREVISIAE, CDK-INHIBITOR, CELL NUCLEAR ANTIGEN, TUMOR-SUPPRESSOR GENE, B-TYPE CYCLIN, GENOME-WIDE ANALYSIS, differentiation, proliferation, checkpoint, CKI, cell cycle

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Citation

Please use this url to cite or link to this publication:

MLA
De Clercq, Annelies, and Dirk Inzé. “Cyclin-dependent Kinase Inhibitors in Yeast, Animals, and Plants: a Functional Comparison.” CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 41.5 (2006): 293–313. Print.
APA
De Clercq, Annelies, & Inzé, D. (2006). Cyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 41(5), 293–313.
Chicago author-date
De Clercq, Annelies, and Dirk Inzé. 2006. “Cyclin-dependent Kinase Inhibitors in Yeast, Animals, and Plants: a Functional Comparison.” Critical Reviews in Biochemistry and Molecular Biology 41 (5): 293–313.
Chicago author-date (all authors)
De Clercq, Annelies, and Dirk Inzé. 2006. “Cyclin-dependent Kinase Inhibitors in Yeast, Animals, and Plants: a Functional Comparison.” Critical Reviews in Biochemistry and Molecular Biology 41 (5): 293–313.
Vancouver
1.
De Clercq A, Inzé D. Cyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2006;41(5):293–313.
IEEE
[1]
A. De Clercq and D. Inzé, “Cyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison,” CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 41, no. 5, pp. 293–313, 2006.
@article{371526,
  abstract     = {The cell cycle is remarkably conserved in yeast, animals, and plants and is controlled by cyclin-dependent kinases (CDKs). CDK activity can be inhibited by binding of CDK inhibitory proteins, designated CKIs. Numerous studies show that CKIs are essential in orchestrating eukaryotic cell proliferation and differentiation. In yeast, animals, and plants, CKIs act as regulators of the G1 checkpoint in response to environmental and developmental cues and assist during mitotic cell cycles by inhibiting CDK activity required to arrest mitosis. Furthermore, CKIs play an important role in regulating cell cycle exit that precedes differentiation and in promoting differentiation in cooperation with transcription factors. Moreover, CKIs are essential to control CDK activity in endocycling cells. So, in yeast, animals, and plants, CKIs share many functional similarities, but their functions are adapted toward the specific needs of the eukaryote.},
  author       = {De Clercq, Annelies and Inzé, Dirk},
  issn         = {1040-9238},
  journal      = {CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY},
  keywords     = {CAENORHABDITIS-ELEGANS,ARABIDOPSIS-THALIANA,PROTEIN-KINASE,G1 CYCLIN,SACCHAROMYCES-CEREVISIAE,CDK-INHIBITOR,CELL NUCLEAR ANTIGEN,TUMOR-SUPPRESSOR GENE,B-TYPE CYCLIN,GENOME-WIDE ANALYSIS,differentiation,proliferation,checkpoint,CKI,cell cycle},
  language     = {eng},
  number       = {5},
  pages        = {293--313},
  title        = {Cyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison},
  url          = {http://dx.doi.org/10.1080/10409230600856685},
  volume       = {41},
  year         = {2006},
}

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