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Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock

(2007) JOURNAL OF IMMUNOLOGY. 178(8). p.5069-5075
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Abstract
In our search for genes that inhibit the inflammatory effects of TNF without diminishing its antitumor capacities we found that, compared with C57BL/6 mice, DBA/2 mice exhibit a dominant resistance to TNF-induced lethality. Tumor-bearing (C57BL/6 X DBA/2)(BXD)F-1 mice completely survived an otherwise lethal TNF/IFN-gamma-antitumor therapy with complete regression of the tumor. This was not the case for C57BL/6 mice. Genetic linkage analysis revealed that TNF resistance is linked to a major locus on distal chromosome 6 and a minor locus on chromosome 17. Compared with littermate controls, chromosome substitution mice carrying a DBA/2 chromosome 6 in a C57BL/6 background were significantly protected against TNF and TNF/IFN-gamma, albeit less so than DBA/2 mice. Definition of a critical region of 13 Mb on chromosome 6 was the highest mapping resolution obtained. Further analysis of candidate genes may provide a powerful tool to control TNF-induced pathologies in humans.
Keywords
PHASE-II TRIAL, TUMOR-NECROSIS-FACTOR, FACTOR-ALPHA, TUBERCULOSIS INFECTION, RHEUMATOID-ARTHRITIS, MULTIPLE-SCLEROSIS, GENETIC DISSECTION, INTERFERON-GAMMA, THERAPY, PATHOGENESIS

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MLA
Wielockx, Ben, Jan Staelens, Leen Puimège, et al. “Description and Mapping of the Resistance of DBA/2 Mice to TNF-induced Lethal Shock.” JOURNAL OF IMMUNOLOGY 178.8 (2007): 5069–5075. Print.
APA
Wielockx, B., Staelens, J., Puimège, L., Vanlaere, I., Van Roy, M., Van Lint, P., Van Roy, F., et al. (2007). Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock. JOURNAL OF IMMUNOLOGY, 178(8), 5069–5075.
Chicago author-date
Wielockx, Ben, Jan Staelens, Leen Puimège, Ineke Vanlaere, Maarten Van Roy, Philippe Van Lint, Frans Van Roy, and Claude Libert. 2007. “Description and Mapping of the Resistance of DBA/2 Mice to TNF-induced Lethal Shock.” Journal of Immunology 178 (8): 5069–5075.
Chicago author-date (all authors)
Wielockx, Ben, Jan Staelens, Leen Puimège, Ineke Vanlaere, Maarten Van Roy, Philippe Van Lint, Frans Van Roy, and Claude Libert. 2007. “Description and Mapping of the Resistance of DBA/2 Mice to TNF-induced Lethal Shock.” Journal of Immunology 178 (8): 5069–5075.
Vancouver
1.
Wielockx B, Staelens J, Puimège L, Vanlaere I, Van Roy M, Van Lint P, et al. Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock. JOURNAL OF IMMUNOLOGY. 2007;178(8):5069–75.
IEEE
[1]
B. Wielockx et al., “Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock,” JOURNAL OF IMMUNOLOGY, vol. 178, no. 8, pp. 5069–5075, 2007.
@article{367699,
  abstract     = {{In our search for genes that inhibit the inflammatory effects of TNF without diminishing its antitumor capacities we found that, compared with C57BL/6 mice, DBA/2 mice exhibit a dominant resistance to TNF-induced lethality. Tumor-bearing (C57BL/6 X DBA/2)(BXD)F-1 mice completely survived an otherwise lethal TNF/IFN-gamma-antitumor therapy with complete regression of the tumor. This was not the case for C57BL/6 mice. Genetic linkage analysis revealed that TNF resistance is linked to a major locus on distal chromosome 6 and a minor locus on chromosome 17. Compared with littermate controls, chromosome substitution mice carrying a DBA/2 chromosome 6 in a C57BL/6 background were significantly protected against TNF and TNF/IFN-gamma, albeit less so than DBA/2 mice. Definition of a critical region of 13 Mb on chromosome 6 was the highest mapping resolution obtained. Further analysis of candidate genes may provide a powerful tool to control TNF-induced pathologies in humans.}},
  author       = {{Wielockx, Ben and Staelens, Jan and Puimège, Leen and Vanlaere, Ineke and Van Roy, Maarten and Van Lint, Philippe and Van Roy, Frans and Libert, Claude}},
  issn         = {{0022-1767}},
  journal      = {{JOURNAL OF IMMUNOLOGY}},
  keywords     = {{PHASE-II TRIAL,TUMOR-NECROSIS-FACTOR,FACTOR-ALPHA,TUBERCULOSIS INFECTION,RHEUMATOID-ARTHRITIS,MULTIPLE-SCLEROSIS,GENETIC DISSECTION,INTERFERON-GAMMA,THERAPY,PATHOGENESIS}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{5069--5075}},
  title        = {{Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock}},
  volume       = {{178}},
  year         = {{2007}},
}

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