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The Arabidopsis leaf as a model system for investigating the role of cell cycle regulation in organ growth

(2006) JOURNAL OF PLANT RESEARCH. 119(1). p.43-50
Author
Organization
Abstract
The role of cell cycle regulation and cell division in plant growth and organ development is controversial. Some experimental data are most easily interpreted from the "cellular perspective" that cell division drives growth, whereas other observations are more consistent with the "organismal perspective" that cell division is merely a consequence of growth, and to a large extent facultative. Here we develop a model of cell cycle regulation in the context of leaf development based on literature, published kinematic analysis, flow-cytometric and transcriptomic data obtained from growing Arabidopsis leaves. We tested this model by comparing the in silico inhibition of the cell cycle progression with the experimental observations of transgenic plants overexpressing the cell cycle inhibitor Arath;KRP2. The model simulates the behaviour of proliferating cells quite well, but is inadequate in describing the effects on expanding cells. This may point to a difference in the nature of the expansion process during the proliferating and non-dividing phase of leaf development.
Keywords
TRANSCRIPTION FACTOR, TRANSITIONS, GENOME-WIDE ANALYSIS, modeling, leaf growth, endoreduplication, cell growth, Arabidopsis, cell division

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Citation

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Chicago
Beemster, Gerrit, Steven Vercruysse, Lieven De Veylder, Martin Kuiper, and Dirk Inzé. 2006. “The Arabidopsis Leaf as a Model System for Investigating the Role of Cell Cycle Regulation in Organ Growth.” Journal of Plant Research 119 (1): 43–50.
APA
Beemster, G., Vercruysse, S., De Veylder, L., Kuiper, M., & Inzé, D. (2006). The Arabidopsis leaf as a model system for investigating the role of cell cycle regulation in organ growth. JOURNAL OF PLANT RESEARCH, 119(1), 43–50.
Vancouver
1.
Beemster G, Vercruysse S, De Veylder L, Kuiper M, Inzé D. The Arabidopsis leaf as a model system for investigating the role of cell cycle regulation in organ growth. JOURNAL OF PLANT RESEARCH. 2006;119(1):43–50.
MLA
Beemster, Gerrit, Steven Vercruysse, Lieven De Veylder, et al. “The Arabidopsis Leaf as a Model System for Investigating the Role of Cell Cycle Regulation in Organ Growth.” JOURNAL OF PLANT RESEARCH 119.1 (2006): 43–50. Print.
@article{366835,
  abstract     = {The role of cell cycle regulation and cell division in plant growth and organ development is controversial. Some experimental data are most easily interpreted from the {\textacutedbl}cellular perspective{\textacutedbl} that cell division drives growth, whereas other observations are more consistent with the {\textacutedbl}organismal perspective{\textacutedbl} that cell division is merely a consequence of growth, and to a large extent facultative. Here we develop a model of cell cycle regulation in the context of leaf development based on literature, published kinematic analysis, flow-cytometric and transcriptomic data obtained from growing Arabidopsis leaves. We tested this model by comparing the in silico inhibition of the cell cycle progression with the experimental observations of transgenic plants overexpressing the cell cycle inhibitor Arath;KRP2. The model simulates the behaviour of proliferating cells quite well, but is inadequate in describing the effects on expanding cells. This may point to a difference in the nature of the expansion process during the proliferating and non-dividing phase of leaf development.},
  author       = {Beemster, Gerrit and Vercruysse, Steven and De Veylder, Lieven and Kuiper, Martin and Inz{\'e}, Dirk},
  issn         = {0918-9440},
  journal      = {JOURNAL OF PLANT RESEARCH},
  keyword      = {TRANSCRIPTION FACTOR,TRANSITIONS,GENOME-WIDE ANALYSIS,modeling,leaf growth,endoreduplication,cell growth,Arabidopsis,cell division},
  language     = {eng},
  number       = {1},
  pages        = {43--50},
  title        = {The Arabidopsis leaf as a model system for investigating the role of cell cycle regulation in organ growth},
  url          = {http://dx.doi.org/10.1007/s10265-005-0234-2},
  volume       = {119},
  year         = {2006},
}

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