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Coupling columns and multidimensional configurations to increase peak capacity in liquid chromatography

Frank David UGent, Gerd Vanhoenacker, Bart Tienpont, Isabelle François UGent and Patrick Sandra UGent (2007) LC GC EUROPE. 20(3). p.154-162
abstract
An overview is presented of possible pathways to enhance peak capacity in liquid chromatography (LC). The peak capacity in a chromatographic separation is directly related to the plate number and thus to column length and particle size. Serial coupled columns can be used to obtain long effective column lengths, reaching over 100000 theoretical plates and peak capacities up to 900. Some theoretical considerations are made on column dimensions and particle size and examples are given of high resolution "GC-like" separations in LC using state-of-the-art LC hardware. Recent developments in LC hardware have also enhanced the applicability of two-dimensional LC-LC and comprehensive LCxLC. Both techniques are extremely powerful to unravel complex samples.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
INSTRUMENTATION, LIMITATIONS
journal title
LC GC EUROPE
LC GC Eur.
volume
20
issue
3
pages
154-+ pages
Web of Science type
Article
Web of Science id
000244927600005
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
0.393 (2007)
JCR rank
64/69 (2007)
JCR quartile
4 (2007)
ISSN
1471-6577
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
366627
handle
http://hdl.handle.net/1854/LU-366627
date created
2007-05-21 12:43:00
date last changed
2010-01-15 09:09:32
@article{366627,
  abstract     = {An overview is presented of possible pathways to enhance peak capacity in liquid chromatography (LC). The peak capacity in a chromatographic separation is directly related to the plate number and thus to column length and particle size.
Serial coupled columns can be used to obtain long effective column lengths, reaching over 100000 theoretical plates and peak capacities up to 900. Some theoretical considerations are made on column dimensions and particle size and examples are given of high resolution {\textacutedbl}GC-like{\textacutedbl} separations in LC using state-of-the-art LC hardware.
Recent developments in LC hardware have also enhanced the applicability of two-dimensional LC-LC and comprehensive LCxLC. Both techniques are extremely powerful to unravel complex samples.},
  author       = {David, Frank and Vanhoenacker, Gerd and Tienpont, Bart and Fran\c{c}ois, Isabelle and Sandra, Patrick},
  issn         = {1471-6577},
  journal      = {LC GC EUROPE},
  keyword      = {INSTRUMENTATION,LIMITATIONS},
  language     = {eng},
  number       = {3},
  pages        = {154--162},
  title        = {Coupling columns and multidimensional configurations to increase peak capacity in liquid chromatography},
  volume       = {20},
  year         = {2007},
}

Chicago
David, Frank, Gerd Vanhoenacker, Bart Tienpont, Isabelle François, and Patrick Sandra. 2007. “Coupling Columns and Multidimensional Configurations to Increase Peak Capacity in Liquid Chromatography.” Lc Gc Europe 20 (3): 154–162.
APA
David, F., Vanhoenacker, G., Tienpont, B., François, I., & Sandra, P. (2007). Coupling columns and multidimensional configurations to increase peak capacity in liquid chromatography. LC GC EUROPE, 20(3), 154–162.
Vancouver
1.
David F, Vanhoenacker G, Tienpont B, François I, Sandra P. Coupling columns and multidimensional configurations to increase peak capacity in liquid chromatography. LC GC EUROPE. 2007;20(3):154–62.
MLA
David, Frank, Gerd Vanhoenacker, Bart Tienpont, et al. “Coupling Columns and Multidimensional Configurations to Increase Peak Capacity in Liquid Chromatography.” LC GC EUROPE 20.3 (2007): 154–162. Print.