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Coupling columns and multidimensional configurations to increase peak capacity in liquid chromatography

(2007) LC GC EUROPE. 20(3). p.154-162
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Abstract
An overview is presented of possible pathways to enhance peak capacity in liquid chromatography (LC). The peak capacity in a chromatographic separation is directly related to the plate number and thus to column length and particle size. Serial coupled columns can be used to obtain long effective column lengths, reaching over 100000 theoretical plates and peak capacities up to 900. Some theoretical considerations are made on column dimensions and particle size and examples are given of high resolution "GC-like" separations in LC using state-of-the-art LC hardware. Recent developments in LC hardware have also enhanced the applicability of two-dimensional LC-LC and comprehensive LCxLC. Both techniques are extremely powerful to unravel complex samples.
Keywords
INSTRUMENTATION, LIMITATIONS

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Citation

Please use this url to cite or link to this publication:

Chicago
David, Frank, Gerd Vanhoenacker, Bart Tienpont, Isabelle François, and Patrick Sandra. 2007. “Coupling Columns and Multidimensional Configurations to Increase Peak Capacity in Liquid Chromatography.” Lc Gc Europe 20 (3): 154–162.
APA
David, F., Vanhoenacker, G., Tienpont, B., François, I., & Sandra, P. (2007). Coupling columns and multidimensional configurations to increase peak capacity in liquid chromatography. LC GC EUROPE, 20(3), 154–162.
Vancouver
1.
David F, Vanhoenacker G, Tienpont B, François I, Sandra P. Coupling columns and multidimensional configurations to increase peak capacity in liquid chromatography. LC GC EUROPE. 2007;20(3):154–62.
MLA
David, Frank, Gerd Vanhoenacker, Bart Tienpont, et al. “Coupling Columns and Multidimensional Configurations to Increase Peak Capacity in Liquid Chromatography.” LC GC EUROPE 20.3 (2007): 154–162. Print.
@article{366627,
  abstract     = {An overview is presented of possible pathways to enhance peak capacity in liquid chromatography (LC). The peak capacity in a chromatographic separation is directly related to the plate number and thus to column length and particle size.
Serial coupled columns can be used to obtain long effective column lengths, reaching over 100000 theoretical plates and peak capacities up to 900. Some theoretical considerations are made on column dimensions and particle size and examples are given of high resolution {\textacutedbl}GC-like{\textacutedbl} separations in LC using state-of-the-art LC hardware.
Recent developments in LC hardware have also enhanced the applicability of two-dimensional LC-LC and comprehensive LCxLC. Both techniques are extremely powerful to unravel complex samples.},
  author       = {David, Frank and Vanhoenacker, Gerd and Tienpont, Bart and Fran\c{c}ois, Isabelle and Sandra, Patrick},
  issn         = {1471-6577},
  journal      = {LC GC EUROPE},
  language     = {eng},
  number       = {3},
  pages        = {154--162},
  title        = {Coupling columns and multidimensional configurations to increase peak capacity in liquid chromatography},
  volume       = {20},
  year         = {2007},
}

Web of Science
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