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NKT cells: manipulable managers of joint inflammation

Ken Coppieters (UGent) , Pieter Dewint (UGent) , Katrien Van Beneden (UGent) , Peggy Jacques (UGent) , Sylvie Seeuws (UGent) , August Verbruggen (UGent) , Dieter Deforce (UGent) and Dirk Elewaut (UGent)
(2007) RHEUMATOLOGY. 46(4). p.565-571
Author
Organization
Abstract
The importance of T cell participation in the aetiology and pathogenesis of rheumatoid arthritis (RA) is now widely appreciated. The disease is mediated by activated pro-inflammatory, self-reactive T helper cells, instigating the chronic autoimmune response characteristic of rheumatoid inflammation. Natural killer T (NKT) cells are a distinctive population of T cells thought to protect self-tissues from damaging inflammatory immune responses, and are often recognized as a regulatory T cell subtype, regulating the magnitude or class of the immune response. Recently, a number of studies have provided insight concerning the role of NKT cells in different models of autoimmune joint inflammation, suggesting the involvement of this specialized T cell subset in controlling initiation and perpetuation of arthritic disease. The aim of this review is to provide rheumatologists with an introduction of the principal features of NKT cells, to give an overview of the data obtained in animal models of arthritis and to discuss the hypothesized mechanisms. Finally, we will speculate on future prospects with regard to NKT cell-targeted treatment of arthritic disease by use of glycolipids.
Keywords
CD1D-RESTRICTED RECOGNITION, rheumatoid arthritis, LIGAND ALPHA-GALACTOSYLCERAMIDE, RHEUMATOID-ARTHRITIS, AUTOIMMUNE-DISEASES, DENDRITIC CELLS, COLLAGEN-INDUCED ARTHRITIS, KILLER T-CELLS, DISTINCT SUBSETS, IMMUNE-RESPONSES, autoimmunity, cytokines, inflammation, NKT cells, mouse, GLYCOLIPID ANTIGENS

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Citation

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MLA
Coppieters, Ken, Pieter Dewint, Katrien Van Beneden, et al. “NKT Cells: Manipulable Managers of Joint Inflammation.” RHEUMATOLOGY 46.4 (2007): 565–571. Print.
APA
Coppieters, K., Dewint, P., Van Beneden, K., Jacques, P., Seeuws, S., Verbruggen, A., Deforce, D., et al. (2007). NKT cells: manipulable managers of joint inflammation. RHEUMATOLOGY, 46(4), 565–571.
Chicago author-date
Coppieters, Ken, Pieter Dewint, Katrien Van Beneden, Peggy Jacques, Sylvie Seeuws, August Verbruggen, Dieter Deforce, and Dirk Elewaut. 2007. “NKT Cells: Manipulable Managers of Joint Inflammation.” Rheumatology 46 (4): 565–571.
Chicago author-date (all authors)
Coppieters, Ken, Pieter Dewint, Katrien Van Beneden, Peggy Jacques, Sylvie Seeuws, August Verbruggen, Dieter Deforce, and Dirk Elewaut. 2007. “NKT Cells: Manipulable Managers of Joint Inflammation.” Rheumatology 46 (4): 565–571.
Vancouver
1.
Coppieters K, Dewint P, Van Beneden K, Jacques P, Seeuws S, Verbruggen A, et al. NKT cells: manipulable managers of joint inflammation. RHEUMATOLOGY. 2007;46(4):565–71.
IEEE
[1]
K. Coppieters et al., “NKT cells: manipulable managers of joint inflammation,” RHEUMATOLOGY, vol. 46, no. 4, pp. 565–571, 2007.
@article{365969,
  abstract     = {The importance of T cell participation in the aetiology and pathogenesis of rheumatoid arthritis (RA) is now widely appreciated. The disease is mediated by activated pro-inflammatory, self-reactive T helper cells, instigating the chronic autoimmune response characteristic of rheumatoid inflammation. Natural killer T (NKT) cells are a distinctive population of T cells thought to protect self-tissues from damaging inflammatory immune responses, and are often recognized as a regulatory T cell subtype, regulating the magnitude or class of the immune response. Recently, a number of studies have provided insight concerning the role of NKT cells in different models of autoimmune joint inflammation, suggesting the involvement of this specialized T cell subset in controlling initiation and perpetuation of arthritic disease. The aim of this review is to provide rheumatologists with an introduction of the principal features of NKT cells, to give an overview of the data obtained in animal models of arthritis and to discuss the hypothesized mechanisms. Finally, we will speculate on future prospects with regard to NKT cell-targeted treatment of arthritic disease by use of glycolipids.},
  author       = {Coppieters, Ken and Dewint, Pieter and Van Beneden, Katrien and Jacques, Peggy and Seeuws, Sylvie and Verbruggen, August and Deforce, Dieter and Elewaut, Dirk},
  issn         = {1462-0324},
  journal      = {RHEUMATOLOGY},
  keywords     = {CD1D-RESTRICTED RECOGNITION,rheumatoid arthritis,LIGAND ALPHA-GALACTOSYLCERAMIDE,RHEUMATOID-ARTHRITIS,AUTOIMMUNE-DISEASES,DENDRITIC CELLS,COLLAGEN-INDUCED ARTHRITIS,KILLER T-CELLS,DISTINCT SUBSETS,IMMUNE-RESPONSES,autoimmunity,cytokines,inflammation,NKT cells,mouse,GLYCOLIPID ANTIGENS},
  language     = {eng},
  number       = {4},
  pages        = {565--571},
  title        = {NKT cells: manipulable managers of joint inflammation},
  url          = {http://dx.doi.org/10.1093/rheumatology/kel437},
  volume       = {46},
  year         = {2007},
}

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