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CARD15 polymorphisms are associated with anti-Saccharomyces cerevisiae antibodies in caucasian Crohn's disease patients

BERT VANDER CRUYSSEN UGent, Harald Peeters UGent, Ilse Hoffman, Debby Laukens UGent, Paul Coucke UGent, DENIS MARICHAL, Claude Cuvelier UGent, Erik Remaut UGent, Eric Veys UGent and Herman Mielants UGent, et al. (2005) CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 140(2). p.354-359
abstract
Carriage of CARD15 gene polymorphisms and the serological marker anti-Saccharomyces cerevisiae antibodies (ASCA) are two markers for Crohn's disease (CD). Similar phenotypes have been associated with both markers. In the present study we analysed whether both markers were associated with each other and, if so, whether this association could be explained by a direct link or by an indirect association with those phenotypes. Therefore, we included 156 consecutive Caucasian CD patients and assessed the prevalence of the three common single nucleotide polymorphisms in the CARD15 gene. Serum samples were analysed for IgA and IgG ASCA by ELISA. CD patients with CARD15 polymorphisms were more frequently ASCA positive (OR 2.7 (1.4-5.2); P = 0.002) and had higher titres for ASCA IgA (P = 0.005) and ASCA IgG (P < 0.001) compared to patients carrying the wild type polymorphisms. Multivariate analysis demonstrated that this association was independent from ileal disease, penetrating disease and stricturing disease, the need for resective bowel surgery, familial cases, smoking habits and early age at onset. Homozygotes or compound heterozygotes for CARD15 polymorphisms had significantly more frequent ASCA positivity compared to single heterozygotes (OR 9.1 (1.1-74.2), P-c (corrected P-value) = 0.030). These data indicate that there is a significant association between the carriage of CARD15 polymorphisms and ASCA, independent of the described phenotypes. Moreover, ASCA positivity is more frequent in CD patients carrying 2 CARD15 polymorphisms compared to single heterozygotes.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CARD15, ASCA, Crohn's disease, caucasian, antibodies, INFLAMMATORY-BOWEL-DISEASE, ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES, PRIMARY SJOGRENS-SYNDROME, RHEUMATOID-ARTHRITIS, 1ST-DEGREE RELATIVES, SEROLOGICAL MARKERS, MANNAN ANTIBODIES, BAKERS-YEAST, NOD2, POPULATION
journal title
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Clin. Exp. Immunol.
volume
140
issue
2
pages
354-359 pages
Web of Science type
Article
Web of Science id
000227968900021
JCR category
IMMUNOLOGY
JCR impact factor
2.805 (2005)
JCR rank
46/113 (2005)
JCR quartile
2 (2005)
ISSN
0009-9104
DOI
10.1111/j.1365-2249.2005.02759.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
363907
handle
http://hdl.handle.net/1854/LU-363907
date created
2005-04-20 13:03:00
date last changed
2015-06-17 10:41:21
@article{363907,
  abstract     = {Carriage of CARD15 gene polymorphisms and the serological marker anti-Saccharomyces cerevisiae antibodies (ASCA) are two markers for Crohn's disease (CD). Similar phenotypes have been associated with both markers. In the present study we analysed whether both markers were associated with each other and, if so, whether this association could be explained by a direct link or by an indirect association with those phenotypes. Therefore, we included 156 consecutive Caucasian CD patients and assessed the prevalence of the three common single nucleotide polymorphisms in the CARD15 gene. Serum samples were analysed for IgA and IgG ASCA by ELISA. CD patients with CARD15 polymorphisms were more frequently ASCA positive (OR 2.7 (1.4-5.2); P = 0.002) and had higher titres for ASCA IgA (P = 0.005) and ASCA IgG (P {\textlangle} 0.001) compared to patients carrying the wild type polymorphisms. Multivariate analysis demonstrated that this association was independent from ileal disease, penetrating disease and stricturing disease, the need for resective bowel surgery, familial cases, smoking habits and early age at onset. Homozygotes or compound heterozygotes for CARD15 polymorphisms had significantly more frequent ASCA positivity compared to single heterozygotes (OR 9.1 (1.1-74.2), P-c (corrected P-value) = 0.030). These data indicate that there is a significant association between the carriage of CARD15 polymorphisms and ASCA, independent of the described phenotypes. Moreover, ASCA positivity is more frequent in CD patients carrying 2 CARD15 polymorphisms compared to single heterozygotes.},
  author       = {VANDER CRUYSSEN, BERT and Peeters, Harald and Hoffman, Ilse and Laukens, Debby and Coucke, Paul and MARICHAL, DENIS and Cuvelier, Claude and Remaut, Erik and Veys, Eric and Mielants, Herman and DE VOS, MARTINE and De Keyser, Filip},
  issn         = {0009-9104},
  journal      = {CLINICAL AND EXPERIMENTAL IMMUNOLOGY},
  keyword      = {CARD15,ASCA,Crohn's disease,caucasian,antibodies,INFLAMMATORY-BOWEL-DISEASE,ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES,PRIMARY SJOGRENS-SYNDROME,RHEUMATOID-ARTHRITIS,1ST-DEGREE RELATIVES,SEROLOGICAL MARKERS,MANNAN ANTIBODIES,BAKERS-YEAST,NOD2,POPULATION},
  language     = {eng},
  number       = {2},
  pages        = {354--359},
  title        = {CARD15 polymorphisms are associated with anti-Saccharomyces cerevisiae antibodies in caucasian Crohn's disease patients},
  url          = {http://dx.doi.org/10.1111/j.1365-2249.2005.02759.x},
  volume       = {140},
  year         = {2005},
}

Chicago
VANDER CRUYSSEN, BERT, Harald Peeters, Ilse Hoffman, Debby Laukens, Paul Coucke, DENIS MARICHAL, Claude Cuvelier, et al. 2005. “CARD15 Polymorphisms Are Associated with anti-Saccharomyces Cerevisiae Antibodies in Caucasian Crohn’s Disease Patients.” Clinical and Experimental Immunology 140 (2): 354–359.
APA
VANDER CRUYSSEN, B., Peeters, H., Hoffman, I., Laukens, D., Coucke, P., MARICHAL, D., Cuvelier, C., et al. (2005). CARD15 polymorphisms are associated with anti-Saccharomyces cerevisiae antibodies in caucasian Crohn’s disease patients. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 140(2), 354–359.
Vancouver
1.
VANDER CRUYSSEN B, Peeters H, Hoffman I, Laukens D, Coucke P, MARICHAL D, et al. CARD15 polymorphisms are associated with anti-Saccharomyces cerevisiae antibodies in caucasian Crohn’s disease patients. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2005;140(2):354–9.
MLA
VANDER CRUYSSEN, BERT, Harald Peeters, Ilse Hoffman, et al. “CARD15 Polymorphisms Are Associated with anti-Saccharomyces Cerevisiae Antibodies in Caucasian Crohn’s Disease Patients.” CLINICAL AND EXPERIMENTAL IMMUNOLOGY 140.2 (2005): 354–359. Print.