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Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps

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Abstract
Background: Chronic rhinosinusitis with nasal polyps is characterized by an eosinophilic inflammation and high IL-5 levels. Objectives: Antagonizing the effect of IL-5 is a potential new treatment strategy in patients with nasal polyps. Methods: In a double-blind, placebo-controlled, randomized, 2-center safety and pharmacokinetic study, 24 subjects with bilateral nasal polyps were randomized to receive a single intravenous infusion of reslizumab, a humanized anti-human IL-5 mAb, at 3 mg/kg or 1 mg/kg or placebo. We evaluated the safety and pharmacokinetics of reslizumab, and biologic activity was assessed by means of endoscopic evaluation of polyp size, symptoms, peripheral eosinophil counts, peripheral and local IL-5 levels, eotaxin levels, and eosinophil cationic protein levels. Results: We demonstrated that a single injection of reslizumab up to 3 mg/kg is safe and well tolerated. Blood eosinophil numbers and concentrations of eosinophil cationic protein were reduced up to 8 weeks after treatment in serum and nasal secretions. Individual nasal polyp scores improved only in half of the treated patients for 4 weeks. Responders had increased IL-5 concentrations in nasal secretions at baseline compared with nonresponders, and logistic regression analysis revealed that increased nasal IL-5 levels (> 40 pg/mL) predict the response to anti-IL-5 treatment. Conclusion: A single injection of anti-IL-5 reduces the size of nasal polyps for 4 weeks in half of the patients, and nasal IL-5 levels predict the response to anti-IL-5 treatment. Clinical implications: Intravenous administration of a humanized anti-human IL-5 mAb is safe and reduces the size of nasal polyps in half of the patients.
Keywords
HYPERREACTIVITY, anti-IL-5, INDUCED AIRWAY HYPERRESPONSIVENESS, HUMAN INTERLEUKIN-5 RECEPTOR, ANTI-INTERLEUKIN-5 ANTIBODY, DECREASED EXPRESSION, HUMAN EOSINOPHILS, ALPHA EXPRESSION, ASTHMA, MEMBRANE, CYTOKINES, IL-5 receptor alpha, IL-5, eosinphils, nasal polyps, chronic rhinosinusitis

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MLA
Gevaert, Philippe, et al. “Nasal IL-5 Levels Determine the Response to Anti-IL-5 Treatment in Patients with Nasal Polyps.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 118, no. 5, 2006, pp. 1133–41, doi:10.1016/j.jaci.2006.05.031.
APA
Gevaert, P., Lang-Loidolt, D., Lackner, A., Stammberger, H., Staudinger, H., Van Zele, T., … Bachert, C. (2006). Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 118(5), 1133–1141. https://doi.org/10.1016/j.jaci.2006.05.031
Chicago author-date
Gevaert, Philippe, Doris Lang-Loidolt, Andreas Lackner, Heinz Stammberger, Heribert Staudinger, Thibaut Van Zele, Gabriële Holtappels, Jan Tavernier, Paul Van Cauwenberge, and Claus Bachert. 2006. “Nasal IL-5 Levels Determine the Response to Anti-IL-5 Treatment in Patients with Nasal Polyps.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 118 (5): 1133–41. https://doi.org/10.1016/j.jaci.2006.05.031.
Chicago author-date (all authors)
Gevaert, Philippe, Doris Lang-Loidolt, Andreas Lackner, Heinz Stammberger, Heribert Staudinger, Thibaut Van Zele, Gabriële Holtappels, Jan Tavernier, Paul Van Cauwenberge, and Claus Bachert. 2006. “Nasal IL-5 Levels Determine the Response to Anti-IL-5 Treatment in Patients with Nasal Polyps.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 118 (5): 1133–1141. doi:10.1016/j.jaci.2006.05.031.
Vancouver
1.
Gevaert P, Lang-Loidolt D, Lackner A, Stammberger H, Staudinger H, Van Zele T, et al. Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;118(5):1133–41.
IEEE
[1]
P. Gevaert et al., “Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps,” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 118, no. 5, pp. 1133–1141, 2006.
@article{360715,
  abstract     = {{Background: Chronic rhinosinusitis with nasal polyps is characterized by an eosinophilic inflammation and high IL-5 levels. 
Objectives: Antagonizing the effect of IL-5 is a potential new treatment strategy in patients with nasal polyps. 
Methods: In a double-blind, placebo-controlled, randomized, 2-center safety and pharmacokinetic study, 24 subjects with bilateral nasal polyps were randomized to receive a single intravenous infusion of reslizumab, a humanized anti-human IL-5 mAb, at 3 mg/kg or 1 mg/kg or placebo. We evaluated the safety and pharmacokinetics of reslizumab, and biologic activity was assessed by means of endoscopic evaluation of polyp size, symptoms, peripheral eosinophil counts, peripheral and local IL-5 levels, eotaxin levels, and eosinophil cationic protein levels. 
Results: We demonstrated that a single injection of reslizumab up to 3 mg/kg is safe and well tolerated. Blood eosinophil numbers and concentrations of eosinophil cationic protein were reduced up to 8 weeks after treatment in serum and nasal secretions. Individual nasal polyp scores improved only in half of the treated patients for 4 weeks. Responders had increased IL-5 concentrations in nasal secretions at baseline compared with nonresponders, and logistic regression analysis revealed that increased nasal IL-5 levels (> 40 pg/mL) predict the response to anti-IL-5 treatment. 
Conclusion: A single injection of anti-IL-5 reduces the size of nasal polyps for 4 weeks in half of the patients, and nasal IL-5 levels predict the response to anti-IL-5 treatment. 
Clinical implications: Intravenous administration of a humanized anti-human IL-5 mAb is safe and reduces the size of nasal polyps in half of the patients.}},
  author       = {{Gevaert, Philippe and Lang-Loidolt, Doris and Lackner, Andreas and Stammberger, Heinz and Staudinger, Heribert and Van Zele, Thibaut and Holtappels, Gabriële and Tavernier, Jan and Van Cauwenberge, Paul and Bachert, Claus}},
  issn         = {{0091-6749}},
  journal      = {{JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY}},
  keywords     = {{HYPERREACTIVITY,anti-IL-5,INDUCED AIRWAY HYPERRESPONSIVENESS,HUMAN INTERLEUKIN-5 RECEPTOR,ANTI-INTERLEUKIN-5 ANTIBODY,DECREASED EXPRESSION,HUMAN EOSINOPHILS,ALPHA EXPRESSION,ASTHMA,MEMBRANE,CYTOKINES,IL-5 receptor alpha,IL-5,eosinphils,nasal polyps,chronic rhinosinusitis}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1133--1141}},
  title        = {{Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps}},
  url          = {{http://doi.org/10.1016/j.jaci.2006.05.031}},
  volume       = {{118}},
  year         = {{2006}},
}

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