Advanced search

Small intestinal brush border enzymes in cystic fibrosis

Author
Organization
Abstract
The study concerns the maltase, saccharase, lactase and alkaline phosphatase activity in small intestinal biopsy specimens from 61 consecutively admitted, untreated, Caucasian cystic fibrosis patients. A group of 319 age matched controls admitted during the same time period for undefined gastrointestinal or nutritional disorders acted as the controls. In order to eliminate morphological damage as a confounding factor, the enzyme activities were studied in small intestinal biopsy specimens having both normal stereomicroscopic and histological features. It was shown that neither maltase nor saccharase activity was different in the two groups, in contrast to lactase and alkaline phophatase activity, that was significantly lower in cystic fibrosis patients. The differences could not be explained by the nutritional status as judged by the body mass index. Lactase activity is known to be easily affected by numerous enteropathies. As the information on alkaline phosphatase activity is limited, the low activity is discussed in more detail. Taking into account the literature data, the low alkaline phophatase activity is tentatively attributed either to enhanced release from the brush border or to the faulty handling of alkaline phophatase protein in the post-golgi compartments secondary to the accumulation of incorrectly glycosylated CFTR in the same cell structures.
Keywords
intestinal alkaline phosphatase, cystic fibrosis, small intestinal brush border enzymes, ALKALINE-PHOSPHATASE, SMALL-BOWEL, RELEASE

Citation

Please use this url to cite or link to this publication:

Chicago
Van Biervliet, Stephanie, Ephrem Eggermont, H Carchon, Gigi Veereman, and Kris Deboeck. 1999. “Small Intestinal Brush Border Enzymes in Cystic Fibrosis.” Acta Gastro-enterologica Belgica 62 (3): 267–271.
APA
Van Biervliet, Stephanie, Eggermont, E., Carchon, H., Veereman, G., & Deboeck, K. (1999). Small intestinal brush border enzymes in cystic fibrosis. ACTA GASTRO-ENTEROLOGICA BELGICA, 62(3), 267–271.
Vancouver
1.
Van Biervliet S, Eggermont E, Carchon H, Veereman G, Deboeck K. Small intestinal brush border enzymes in cystic fibrosis. ACTA GASTRO-ENTEROLOGICA BELGICA. 1999;62(3):267–71.
MLA
Van Biervliet, Stephanie, Ephrem Eggermont, H Carchon, et al. “Small Intestinal Brush Border Enzymes in Cystic Fibrosis.” ACTA GASTRO-ENTEROLOGICA BELGICA 62.3 (1999): 267–271. Print.
@article{337068,
  abstract     = {The study concerns the maltase, saccharase, lactase and alkaline phosphatase activity in small intestinal biopsy specimens from 61 consecutively admitted, untreated, Caucasian cystic fibrosis patients. A group of 319 age matched controls admitted during the same time period for undefined gastrointestinal or nutritional disorders acted as the controls. 
In order to eliminate morphological damage as a confounding factor, the enzyme activities were studied in small intestinal biopsy specimens having both normal stereomicroscopic and histological features. It was shown that neither maltase nor saccharase activity was different in the two groups, in contrast to lactase and alkaline phophatase activity, that was significantly lower in cystic fibrosis patients. The differences could not be explained by the nutritional status as judged by the body mass index. 
Lactase activity is known to be easily affected by numerous enteropathies. As the information on alkaline phosphatase activity is limited, the low activity is discussed in more detail. Taking into account the literature data, the low alkaline phophatase activity is tentatively attributed either to enhanced release from the brush border or to the faulty handling of alkaline phophatase protein in the post-golgi compartments secondary to the accumulation of incorrectly glycosylated CFTR in the same cell structures.},
  author       = {Van Biervliet, Stephanie and Eggermont, Ephrem and Carchon, H and Veereman, Gigi and Deboeck, Kris},
  issn         = {0001-5644},
  journal      = {ACTA GASTRO-ENTEROLOGICA BELGICA},
  keyword      = {intestinal alkaline phosphatase,cystic fibrosis,small intestinal brush border enzymes,ALKALINE-PHOSPHATASE,SMALL-BOWEL,RELEASE},
  language     = {eng},
  number       = {3},
  pages        = {267--271},
  title        = {Small intestinal brush border enzymes in cystic fibrosis},
  volume       = {62},
  year         = {1999},
}

Web of Science
Times cited: