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Small intestinal brush border enzymes in cystic fibrosis

Stephanie Van Biervliet UGent, Ephrem Eggermont, H Carchon, Gigi Veereman and Kris Deboeck (1999) ACTA GASTRO-ENTEROLOGICA BELGICA. 62(3). p.267-271
abstract
The study concerns the maltase, saccharase, lactase and alkaline phosphatase activity in small intestinal biopsy specimens from 61 consecutively admitted, untreated, Caucasian cystic fibrosis patients. A group of 319 age matched controls admitted during the same time period for undefined gastrointestinal or nutritional disorders acted as the controls. In order to eliminate morphological damage as a confounding factor, the enzyme activities were studied in small intestinal biopsy specimens having both normal stereomicroscopic and histological features. It was shown that neither maltase nor saccharase activity was different in the two groups, in contrast to lactase and alkaline phophatase activity, that was significantly lower in cystic fibrosis patients. The differences could not be explained by the nutritional status as judged by the body mass index. Lactase activity is known to be easily affected by numerous enteropathies. As the information on alkaline phosphatase activity is limited, the low activity is discussed in more detail. Taking into account the literature data, the low alkaline phophatase activity is tentatively attributed either to enhanced release from the brush border or to the faulty handling of alkaline phophatase protein in the post-golgi compartments secondary to the accumulation of incorrectly glycosylated CFTR in the same cell structures.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
intestinal alkaline phosphatase, cystic fibrosis, small intestinal brush border enzymes, ALKALINE-PHOSPHATASE, SMALL-BOWEL, RELEASE
journal title
ACTA GASTRO-ENTEROLOGICA BELGICA
Acta Gastro-Enterol. Belg.
volume
62
issue
3
pages
267 - 271
Web of Science type
Article
Web of Science id
000085277300002
ISSN
0001-5644
language
English
UGent publication?
no
classification
A1
id
337068
handle
http://hdl.handle.net/1854/LU-337068
date created
2006-06-01 16:46:00
date last changed
2014-11-26 13:37:02
@article{337068,
  abstract     = {The study concerns the maltase, saccharase, lactase and alkaline phosphatase activity in small intestinal biopsy specimens from 61 consecutively admitted, untreated, Caucasian cystic fibrosis patients. A group of 319 age matched controls admitted during the same time period for undefined gastrointestinal or nutritional disorders acted as the controls. 
In order to eliminate morphological damage as a confounding factor, the enzyme activities were studied in small intestinal biopsy specimens having both normal stereomicroscopic and histological features. It was shown that neither maltase nor saccharase activity was different in the two groups, in contrast to lactase and alkaline phophatase activity, that was significantly lower in cystic fibrosis patients. The differences could not be explained by the nutritional status as judged by the body mass index. 
Lactase activity is known to be easily affected by numerous enteropathies. As the information on alkaline phosphatase activity is limited, the low activity is discussed in more detail. Taking into account the literature data, the low alkaline phophatase activity is tentatively attributed either to enhanced release from the brush border or to the faulty handling of alkaline phophatase protein in the post-golgi compartments secondary to the accumulation of incorrectly glycosylated CFTR in the same cell structures.},
  author       = {Van Biervliet, Stephanie and Eggermont, Ephrem and Carchon, H and Veereman, Gigi and Deboeck, Kris},
  issn         = {0001-5644},
  journal      = {ACTA GASTRO-ENTEROLOGICA BELGICA},
  keyword      = {intestinal alkaline phosphatase,cystic fibrosis,small intestinal brush border enzymes,ALKALINE-PHOSPHATASE,SMALL-BOWEL,RELEASE},
  language     = {eng},
  number       = {3},
  pages        = {267--271},
  title        = {Small intestinal brush border enzymes in cystic fibrosis},
  volume       = {62},
  year         = {1999},
}

Chicago
Van Biervliet, Stephanie, Ephrem Eggermont, H Carchon, Gigi Veereman, and Kris Deboeck. 1999. “Small Intestinal Brush Border Enzymes in Cystic Fibrosis.” Acta Gastro-enterologica Belgica 62 (3): 267–271.
APA
Van Biervliet, Stephanie, Eggermont, E., Carchon, H., Veereman, G., & Deboeck, K. (1999). Small intestinal brush border enzymes in cystic fibrosis. ACTA GASTRO-ENTEROLOGICA BELGICA, 62(3), 267–271.
Vancouver
1.
Van Biervliet S, Eggermont E, Carchon H, Veereman G, Deboeck K. Small intestinal brush border enzymes in cystic fibrosis. ACTA GASTRO-ENTEROLOGICA BELGICA. 1999;62(3):267–71.
MLA
Van Biervliet, Stephanie, Ephrem Eggermont, H Carchon, et al. “Small Intestinal Brush Border Enzymes in Cystic Fibrosis.” ACTA GASTRO-ENTEROLOGICA BELGICA 62.3 (1999): 267–271. Print.