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Functional divergence of proteins through frameshift mutations

Jeroen Raes and Yves Van de Peer UGent (2005) TRENDS IN GENETICS. 21(8). p.428-431
abstract
Frameshift mutations are generally considered to be deleterious and of little importance for the evolution of novel gene functions. However, by screening an exhaustive set of vertebrate gene families, we found that, when a second transcript encoding the original gene product compensates for this mutation, frameshift mutations can be retained for millions of years and enable new gene functions to be acquired.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
EVOLUTION, GENES, GENOME, DATABASE, CLONING, FAMILY, DECAY, PAX8, OLD
journal title
TRENDS IN GENETICS
Trends Genet.
volume
21
issue
8
pages
428 - 431
Web of Science type
Article
Web of Science id
000231209200003
JCR category
GENETICS & HEREDITY
JCR impact factor
12.047 (2005)
JCR rank
7/119 (2005)
JCR quartile
1 (2005)
ISSN
0168-9525
DOI
10.1016/j.tig.2005.05.013
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
331404
handle
http://hdl.handle.net/1854/LU-331404
date created
2006-04-14 14:03:00
date last changed
2012-12-19 15:32:30
@article{331404,
  abstract     = {Frameshift mutations are generally considered to be deleterious and of little importance for the evolution of novel gene functions. However, by screening an exhaustive set of vertebrate gene families, we found that, when a second transcript encoding the original gene product compensates for this mutation, frameshift mutations can be retained for millions of years and enable new gene functions to be acquired.},
  author       = {Raes, Jeroen and Van de Peer, Yves},
  issn         = {0168-9525},
  journal      = {TRENDS IN GENETICS},
  keyword      = {EVOLUTION,GENES,GENOME,DATABASE,CLONING,FAMILY,DECAY,PAX8,OLD},
  language     = {eng},
  number       = {8},
  pages        = {428--431},
  title        = {Functional divergence of proteins through frameshift mutations},
  url          = {http://dx.doi.org/10.1016/j.tig.2005.05.013},
  volume       = {21},
  year         = {2005},
}

Chicago
Raes, Jeroen, and Yves Van de Peer. 2005. “Functional Divergence of Proteins Through Frameshift Mutations.” Trends in Genetics 21 (8): 428–431.
APA
Raes, J., & Van de Peer, Y. (2005). Functional divergence of proteins through frameshift mutations. TRENDS IN GENETICS, 21(8), 428–431.
Vancouver
1.
Raes J, Van de Peer Y. Functional divergence of proteins through frameshift mutations. TRENDS IN GENETICS. 2005;21(8):428–31.
MLA
Raes, Jeroen, and Yves Van de Peer. “Functional Divergence of Proteins Through Frameshift Mutations.” TRENDS IN GENETICS 21.8 (2005): 428–431. Print.