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The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division

Zoltán Magyar UGent, Lieven De Veylder UGent, Ana Atanassova, László Bakó, Dirk Inzé UGent and László Bögre (2005) PLANT CELL. 17(9). p.2527-2541
abstract
The molecular mechanisms by which the phytohormone auxin coordinates cell division with cell growth and differentiation are largely unknown. Here, we show that in Arabidopsis thaliana E2FB, accumulation and stability are positively regulated by auxin. Coexpression of E2FB, but not of E2FA, with its dimerization partner A, stimulated cell proliferation in the absence of auxin in tobacco ( Nicotiana tabacum) Bright Yellow-2 cells. E2FB regulated the entry into both S- and M-phases, the latter corresponding to the activation of a plant-specific mitotic regulator, CDKB1; 1. Increased E2FB levels led to shortened cell cycle duration, elevated cell numbers, and extremely small cell sizes. In the absence of auxin, cells elongated with concomitant increase in their ploidy level, but both were strongly inhibited by E2FB. We conclude that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PROLIFERATION, PATHWAY, EXPRESSION, RECEPTOR, DIFFERENTIATION, ENDOREDUPLICATION, TOBACCO, CYCLE, MEDIATED PLANT TRANSFORMATION, BOX PROTEIN TIR1
journal title
PLANT CELL
Plant Cell
volume
17
issue
9
pages
2527 - 2541
Web of Science type
Article
Web of Science id
000231598400010
JCR category
PLANT SCIENCES
JCR impact factor
11.088 (2005)
JCR rank
2/143 (2005)
JCR quartile
1 (2005)
ISSN
1040-4651
DOI
10.1105/tpc.105.033761
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
330971
handle
http://hdl.handle.net/1854/LU-330971
date created
2006-04-13 18:46:00
date last changed
2016-12-19 15:44:10
@article{330971,
  abstract     = {The molecular mechanisms by which the phytohormone auxin coordinates cell division with cell growth and differentiation are largely unknown. Here, we show that in Arabidopsis thaliana E2FB, accumulation and stability are positively regulated by auxin. Coexpression of E2FB, but not of E2FA, with its dimerization partner A, stimulated cell proliferation in the absence of auxin in tobacco ( Nicotiana tabacum) Bright Yellow-2 cells. E2FB regulated the entry into both S- and M-phases, the latter corresponding to the activation of a plant-specific mitotic regulator, CDKB1; 1. Increased E2FB levels led to shortened cell cycle duration, elevated cell numbers, and extremely small cell sizes. In the absence of auxin, cells elongated with concomitant increase in their ploidy level, but both were strongly inhibited by E2FB. We conclude that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.},
  author       = {Magyar, Zolt{\'a}n and De Veylder, Lieven and Atanassova, Ana and Bak{\'o}, L{\'a}szl{\'o} and Inz{\'e}, Dirk and B{\"o}gre, L{\'a}szl{\'o}},
  issn         = {1040-4651},
  journal      = {PLANT CELL},
  keyword      = {PROLIFERATION,PATHWAY,EXPRESSION,RECEPTOR,DIFFERENTIATION,ENDOREDUPLICATION,TOBACCO,CYCLE,MEDIATED PLANT TRANSFORMATION,BOX PROTEIN TIR1},
  language     = {eng},
  number       = {9},
  pages        = {2527--2541},
  title        = {The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division},
  url          = {http://dx.doi.org/10.1105/tpc.105.033761},
  volume       = {17},
  year         = {2005},
}

Chicago
Magyar, Zoltán, Lieven De Veylder, Ana Atanassova, László Bakó, Dirk Inzé, and László Bögre. 2005. “The Role of the Arabidopsis E2FB Transcription Factor in Regulating Auxin-dependent Cell Division.” Plant Cell 17 (9): 2527–2541.
APA
Magyar, Z., De Veylder, L., Atanassova, A., Bakó, L., Inzé, D., & Bögre, L. (2005). The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division. PLANT CELL, 17(9), 2527–2541.
Vancouver
1.
Magyar Z, De Veylder L, Atanassova A, Bakó L, Inzé D, Bögre L. The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division. PLANT CELL. 2005;17(9):2527–41.
MLA
Magyar, Zoltán, Lieven De Veylder, Ana Atanassova, et al. “The Role of the Arabidopsis E2FB Transcription Factor in Regulating Auxin-dependent Cell Division.” PLANT CELL 17.9 (2005): 2527–2541. Print.