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Benign and malignant musculoskeletal lesions : dynamic contrast-enhanced MR imaging : parametric 'first-pass' images depict tissue vascularization and perfusion

(1994) RADIOLOGY. 192(3). p.835-843
Author
Organization
Abstract
PURPOSE: To assess the diagnostic value of parametric magnetic resonance images that display the first pass (FP) of gadopentetate dimeglumine. MATERIALS AND METHODS: Dynamic, contrast material-enhanced, fast low-angle shot MR imaging was performed of 100 musculoskeletal lesions in 36 female and 64 male patients (aged 9-81 years [mean, 34 years]). The highest slope value of the time-intensity curve was calculated pixel by pixel and displayed on the FP image, with a gray-scale value equal to the slope value. Tissue vascularization and perfusion were evaluated at pathologic and angiographic examinations in 33 lesions. RESULTS: A significant difference (P < .001) was found between the FP slope values of benign (mean, 36.2% per second) and malignant (mean, 67.4% per second) lesions. FP images depicted tissue vascularization and perfusion rather than benignity or malignancy, because there is an overlap in the slope values of highly vascular benign lesions and malignant lesions. CONCLUSION: FP images provide diagnostically useful information by depicting tissue vascularization and perfusion.
Keywords
OSTEO-SARCOMA, GD-DTPA, PREOPERATIVE CHEMOTHERAPY, MR, SOFT TISSUES, OSTEOSARCOMA, MR, MUSCLES, PERFUSION STUDY, MAGNETIC RESONANCE (MR), GADOLINIUM, EWING SARCOMA, ENCHONDROMA, BONES, MR, PROGNOSTIC FACTOR, EWING SARCOMA, OSTEOSARCOMA, TUMOR, NEOPLASMS

Citation

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Chicago
Verstraete, Koenraad, Yves De Deene, H Roels, A Dierick, Dirk Uyttendaele, and Marc Kunnen. 1994. “Benign and Malignant Musculoskeletal Lesions : Dynamic Contrast-enhanced MR Imaging : Parametric ‘First-pass’ Images Depict Tissue Vascularization and Perfusion.” Radiology 192 (3): 835–843.
APA
Verstraete, Koenraad, De Deene, Y., Roels, H., Dierick, A., Uyttendaele, D., & Kunnen, M. (1994). Benign and malignant musculoskeletal lesions : dynamic contrast-enhanced MR imaging : parametric “first-pass” images depict tissue vascularization and perfusion. RADIOLOGY, 192(3), 835–843.
Vancouver
1.
Verstraete K, De Deene Y, Roels H, Dierick A, Uyttendaele D, Kunnen M. Benign and malignant musculoskeletal lesions : dynamic contrast-enhanced MR imaging : parametric “first-pass” images depict tissue vascularization and perfusion. RADIOLOGY. 1994;192(3):835–43.
MLA
Verstraete, Koenraad, Yves De Deene, H Roels, et al. “Benign and Malignant Musculoskeletal Lesions : Dynamic Contrast-enhanced MR Imaging : Parametric ‘First-pass’ Images Depict Tissue Vascularization and Perfusion.” RADIOLOGY 192.3 (1994): 835–843. Print.
@article{330075,
  abstract     = {PURPOSE: To assess the diagnostic value of parametric magnetic resonance images that display the first pass (FP) of gadopentetate dimeglumine. 
MATERIALS AND METHODS: Dynamic, contrast material-enhanced, fast low-angle shot MR imaging was performed of 100 musculoskeletal lesions in 36 female and 64 male patients (aged 9-81 years [mean, 34 years]). The highest slope value of the time-intensity curve was calculated pixel by pixel and displayed on the FP image, with a gray-scale value equal to the slope value. Tissue vascularization and perfusion were evaluated at pathologic and angiographic examinations in 33 lesions. 
RESULTS: A significant difference (P {\textlangle} .001) was found between the FP slope values of benign (mean, 36.2\% per second) and malignant (mean, 67.4\% per second) lesions. FP images depicted tissue vascularization and perfusion rather than benignity or malignancy, because there is an overlap in the slope values of highly vascular benign lesions and malignant lesions. 
CONCLUSION: FP images provide diagnostically useful information by depicting tissue vascularization and perfusion.},
  author       = {Verstraete, Koenraad and De Deene, Yves and Roels, H and Dierick, A and Uyttendaele, Dirk and Kunnen, Marc},
  issn         = {0033-8419},
  journal      = {RADIOLOGY},
  language     = {eng},
  number       = {3},
  pages        = {835--843},
  title        = {Benign and malignant musculoskeletal lesions : dynamic contrast-enhanced MR imaging : parametric 'first-pass' images depict tissue vascularization and perfusion},
  url          = {http://dx.doi.org/10.1148/radiology.192.3.8058957},
  volume       = {192},
  year         = {1994},
}

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