Ghent University Academic Bibliography

Advanced

Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator

Catherine Gondcaille, Marianne Depreter, Stéphane Fourcade, Maria Rita Lecca, Sabrina Leclercq, Pascal GP Martin, Thierry Pineau, Françoise Cadepond, Martine ElEtr and Nathalie Bertrand, et al. (2005) JOURNAL OF CELL BIOLOGY. 169(1). p.93-104
abstract
X-linked adrenoleukodystrophy (X-ALD) is a demyelinating disease due to mutations in the ABCD1 (ALD) gene, encoding a peroxisomal ATP-binding cassette transporter (ALDP). Overexpression of adrenoleukodystrophy-related protein, an ALDP homologue encoded by the AB CD2 (adrenoleukodystrophy-related) gene, can compensate for ALDP deficiency. 4-Phenyl-butyrate (PBA) has been shown to induce both ABCD2 expression and peroxisome proliferation in human fibroblasts. We show that peroxisome proliferation with unusual shapes and clusters occurred in liver of PBA-treated rodents in a PPAR alpha-independent way. PBA activated Abcd2 in cultured glial cells, making PBA a candidate drug for therapy of X-ALD. The Abcd2 induction observed was partially PPAR alpha independent in hepatocytes and totally independent in fibroblasts. We demonstrate that a GC box and a CCAAT box of the Abcd2 promoter are the key elements of the PBA-dependent Abcd2 induction, histone deacetylase (HDAC) 1 being recruited by the GC box. Thus, PBA is a nonclassical peroxisome proliferator inducing pleiotropic effects, including effects at the peroxisomal level mainly through HDAC inhibition.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
HISTONE DEACETYLASE, X-LINKED ADRENOLEUKODYSTROPHY, ACTIVATED RECEPTOR, MEMBRANE-PROTEIN, TRANSCRIPTIONAL REGULATION, EXPRESSION PATTERN, ABC-TRANSPORTER, BETA-OXIDATION, RAT-LIVER, NF-Y
journal title
JOURNAL OF CELL BIOLOGY
J. Cell Biol.
volume
169
issue
1
pages
93-104 pages
Web of Science type
Article
Web of Science id
000228327500009
JCR category
CELL BIOLOGY
JCR impact factor
10.951 (2005)
JCR rank
12/152 (2005)
JCR quartile
1 (2005)
ISSN
0021-9525
DOI
10.1083/jcb.200501036
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
326696
handle
http://hdl.handle.net/1854/LU-326696
date created
2006-02-21 15:53:00
date last changed
2010-03-11 09:53:04
@article{326696,
  abstract     = {X-linked adrenoleukodystrophy (X-ALD) is a demyelinating disease due to mutations in the ABCD1 (ALD) gene, encoding a peroxisomal ATP-binding cassette transporter (ALDP). Overexpression of adrenoleukodystrophy-related protein, an ALDP homologue encoded by the AB CD2 (adrenoleukodystrophy-related) gene, can compensate for ALDP deficiency. 4-Phenyl-butyrate (PBA) has been shown to induce both ABCD2 expression and peroxisome proliferation in human fibroblasts. We show that peroxisome proliferation with unusual shapes and clusters occurred in liver of PBA-treated rodents in a PPAR alpha-independent way. PBA activated Abcd2 in cultured glial cells, making PBA a candidate drug for therapy of X-ALD. The Abcd2 induction observed was partially PPAR alpha independent in hepatocytes and totally independent in fibroblasts. We demonstrate that a GC box and a CCAAT box of the Abcd2 promoter are the key elements of the PBA-dependent Abcd2 induction, histone deacetylase (HDAC) 1 being recruited by the GC box. Thus, PBA is a nonclassical peroxisome proliferator inducing pleiotropic effects, including effects at the peroxisomal level mainly through HDAC inhibition.},
  author       = {Gondcaille, Catherine and Depreter, Marianne and Fourcade, St{\'e}phane and Lecca, Maria Rita and Leclercq, Sabrina and Martin, Pascal GP and Pineau, Thierry and Cadepond, Fran\c{c}oise and ElEtr, Martine and Bertrand, Nathalie and Beley, Alain and Duclos, Sandrine and De Craemer, Dirk and Roels, Frank and Savary, St{\'e}phane and Bugaut, Maurice},
  issn         = {0021-9525},
  journal      = {JOURNAL OF CELL BIOLOGY},
  keyword      = {HISTONE DEACETYLASE,X-LINKED ADRENOLEUKODYSTROPHY,ACTIVATED RECEPTOR,MEMBRANE-PROTEIN,TRANSCRIPTIONAL REGULATION,EXPRESSION PATTERN,ABC-TRANSPORTER,BETA-OXIDATION,RAT-LIVER,NF-Y},
  language     = {eng},
  number       = {1},
  pages        = {93--104},
  title        = {Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator},
  url          = {http://dx.doi.org/10.1083/jcb.200501036},
  volume       = {169},
  year         = {2005},
}

Chicago
Gondcaille, Catherine, Marianne Depreter, Stéphane Fourcade, Maria Rita Lecca, Sabrina Leclercq, Pascal GP Martin, Thierry Pineau, et al. 2005. “Phenylbutyrate Up-regulates the Adrenoleukodystrophy-related Gene as a Nonclassical Peroxisome Proliferator.” Journal of Cell Biology 169 (1): 93–104.
APA
Gondcaille, C., Depreter, M., Fourcade, S., Lecca, M. R., Leclercq, S., Martin, P. G., Pineau, T., et al. (2005). Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator. JOURNAL OF CELL BIOLOGY, 169(1), 93–104.
Vancouver
1.
Gondcaille C, Depreter M, Fourcade S, Lecca MR, Leclercq S, Martin PG, et al. Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator. JOURNAL OF CELL BIOLOGY. 2005;169(1):93–104.
MLA
Gondcaille, Catherine, Marianne Depreter, Stéphane Fourcade, et al. “Phenylbutyrate Up-regulates the Adrenoleukodystrophy-related Gene as a Nonclassical Peroxisome Proliferator.” JOURNAL OF CELL BIOLOGY 169.1 (2005): 93–104. Print.