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Many faces of DAMPs in cancer therapy

Olga Krysko (UGent) , Tania Love Aaes (UGent) , Claus Bachert (UGent) , Peter Vandenabeele (UGent) and Dmitri Krysko (UGent)
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Abstract
A new concept of immunogenic cell death (ICD) has recently been proposed. The immunogenic characteristics of this cell death mode are mediated mainly by molecules called ‘damage-associated molecular patterns’ (DAMPs), most of which are recognized by pattern recognition receptors. Some DAMPs are actively emitted by cells undergoing ICD (e.g. calreticulin (CRT) and adenosine triphosphate (ATP)), whereas others are emitted passively (e.g. high-mobility group box 1 protein (HMGB1)). Recent studies have demonstrated that these DAMPs play a beneficial role in anti-cancer therapy by interacting with the immune system. The molecular pathways involved in translocation of CRT to the cell surface and secretion of ATP from tumor cells undergoing ICD are being elucidated. However, it has also been shown that the same DAMPs could contribute to progression of cancer and promote resistance to anticancer treatments. In this review, we will critically evaluate the beneficial and detrimental roles of DAMPs in cancer therapy, focusing mainly on CRT, ATP and HMGB1.
Keywords
HMGB1, CALRETICULIN EXPOSURE, TLRs, IMMUNOGENIC CELL-DEATH, ACUTE MYELOID-LEUKEMIA, EXTRACELLULAR ATP, IMMUNE-RESPONSES, DENDRITIC CELLS, TUMOR-CELLS, FIND-ME SIGNAL, SMOOTH-MUSCLE-CELLS, immunogenic cell death, MOBILITY GROUP BOX-1, ATP, calreticulin

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Please use this url to cite or link to this publication:

MLA
Krysko, Olga, Tania Love Aaes, Claus Bachert, et al. “Many Faces of DAMPs in Cancer Therapy.” CELL DEATH & DISEASE 4 (2013): n. pag. Print.
APA
Krysko, O., Aaes, T. L., Bachert, C., Vandenabeele, P., & Krysko, D. (2013). Many faces of DAMPs in cancer therapy. CELL DEATH & DISEASE, 4.
Chicago author-date
Krysko, Olga, Tania Love Aaes, Claus Bachert, Peter Vandenabeele, and Dmitri Krysko. 2013. “Many Faces of DAMPs in Cancer Therapy.” Cell Death & Disease 4.
Chicago author-date (all authors)
Krysko, Olga, Tania Love Aaes, Claus Bachert, Peter Vandenabeele, and Dmitri Krysko. 2013. “Many Faces of DAMPs in Cancer Therapy.” Cell Death & Disease 4.
Vancouver
1.
Krysko O, Aaes TL, Bachert C, Vandenabeele P, Krysko D. Many faces of DAMPs in cancer therapy. CELL DEATH & DISEASE. 2013;4.
IEEE
[1]
O. Krysko, T. L. Aaes, C. Bachert, P. Vandenabeele, and D. Krysko, “Many faces of DAMPs in cancer therapy,” CELL DEATH & DISEASE, vol. 4, 2013.
@article{3258500,
  abstract     = {A new concept of immunogenic cell death (ICD) has recently been proposed. The immunogenic characteristics of this cell death mode are mediated mainly by molecules called ‘damage-associated molecular patterns’ (DAMPs), most of which are recognized by pattern recognition receptors. Some DAMPs are actively emitted by cells undergoing ICD (e.g. calreticulin (CRT) and adenosine triphosphate (ATP)), whereas others are emitted passively (e.g. high-mobility group box 1 protein (HMGB1)). Recent studies have demonstrated that these DAMPs play a beneficial role in anti-cancer therapy by interacting with the immune system. The molecular pathways involved in translocation of CRT to the cell surface and secretion of ATP from tumor cells undergoing ICD are being elucidated. However, it has also been shown that the same DAMPs could contribute to progression of cancer and promote resistance to anticancer treatments. In this review, we will critically evaluate the beneficial and detrimental roles of DAMPs in cancer therapy, focusing mainly on CRT, ATP and HMGB1.},
  articleno    = {e631},
  author       = {Krysko, Olga and Aaes, Tania Love and Bachert, Claus and Vandenabeele, Peter and Krysko, Dmitri},
  issn         = {2041-4889},
  journal      = {CELL DEATH & DISEASE},
  keywords     = {HMGB1,CALRETICULIN EXPOSURE,TLRs,IMMUNOGENIC CELL-DEATH,ACUTE MYELOID-LEUKEMIA,EXTRACELLULAR ATP,IMMUNE-RESPONSES,DENDRITIC CELLS,TUMOR-CELLS,FIND-ME SIGNAL,SMOOTH-MUSCLE-CELLS,immunogenic cell death,MOBILITY GROUP BOX-1,ATP,calreticulin},
  language     = {eng},
  pages        = {7},
  title        = {Many faces of DAMPs in cancer therapy},
  url          = {http://dx.doi.org/10.1038/cddis.2013.156},
  volume       = {4},
  year         = {2013},
}

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