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Sedimentation and resuspendability evaluation of pharmaceutical suspensions by low-field one dimensional pulsed field gradient NMR profilometry

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Abstract
In order to study the sedimentation of pharmaceutical suspensions using low-field one dimensional pulsed field gradient nuclear magnetic resonance (1D pfg NMR) profilometry, the accuracy of signal acquisition as well as the spatial resolution of a commercial spectrometer operating at 23.4 MHz was investigated. The use of a solid Teflon spacer revealed that the accuracy of signal acquisition was independent of spatial position (height). The standard deviation of distance determinations was less than 150 mu m, whereas the accuracy of water content determination was within 2% in the central part of the detection zone and deteriorated to 4% in the outer parts. The study of aqueous paramagnetic MnCl 2 solutions indicated an exponential relationship between the relative signal intensity and the transverse relaxation decay constant. From this relationship, the relative water content of suspensions could be derived from their signal intensity relative to that of water. Using concentrated paliperidone palmitate dispersions as model suspensions, low-field 1D pfg NMR profilometry has been proven to be suitable for the evaluation of both the sedimentation and resuspendability behavior of viscous, opaque suspensions, for which visual detection of homogeneity may be difficult.
Keywords
nuclear magnetic resonance, Pulsed field gradient, suspension, sediment characterization, sedimentation, resuspendability, IN-OIL MICROEMULSIONS, POLYETHYLENE-GLYCOL, POLYSTYRENE LATEX, DOSE UNIFORMITY, SIZE, MRI, REDISPERSIBILITY, FLOCCULATION, CYCLOHEXANE, PARTICLES

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MLA
Zhu, Wuxin, et al. “Sedimentation and Resuspendability Evaluation of Pharmaceutical Suspensions by Low-Field One Dimensional Pulsed Field Gradient NMR Profilometry.” PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 18, no. 4, 2013, pp. 787–97, doi:10.3109/10837450.2011.614252.
APA
Zhu, W., Martins, J., Saveyn, P., Govoreanu, R., Verbruggen, K., Ariën, T., … Van der Meeren, P. (2013). Sedimentation and resuspendability evaluation of pharmaceutical suspensions by low-field one dimensional pulsed field gradient NMR profilometry. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 18(4), 787–797. https://doi.org/10.3109/10837450.2011.614252
Chicago author-date
Zhu, Wuxin, José Martins, Pieter Saveyn, Ruxandra Govoreanu, Katrien Verbruggen, Tina Ariën, Arne Verliefde, and Paul Van der Meeren. 2013. “Sedimentation and Resuspendability Evaluation of Pharmaceutical Suspensions by Low-Field One Dimensional Pulsed Field Gradient NMR Profilometry.” PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 18 (4): 787–97. https://doi.org/10.3109/10837450.2011.614252.
Chicago author-date (all authors)
Zhu, Wuxin, José Martins, Pieter Saveyn, Ruxandra Govoreanu, Katrien Verbruggen, Tina Ariën, Arne Verliefde, and Paul Van der Meeren. 2013. “Sedimentation and Resuspendability Evaluation of Pharmaceutical Suspensions by Low-Field One Dimensional Pulsed Field Gradient NMR Profilometry.” PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 18 (4): 787–797. doi:10.3109/10837450.2011.614252.
Vancouver
1.
Zhu W, Martins J, Saveyn P, Govoreanu R, Verbruggen K, Ariën T, et al. Sedimentation and resuspendability evaluation of pharmaceutical suspensions by low-field one dimensional pulsed field gradient NMR profilometry. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY. 2013;18(4):787–97.
IEEE
[1]
W. Zhu et al., “Sedimentation and resuspendability evaluation of pharmaceutical suspensions by low-field one dimensional pulsed field gradient NMR profilometry,” PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 18, no. 4, pp. 787–797, 2013.
@article{3257546,
  abstract     = {{In order to study the sedimentation of pharmaceutical suspensions using low-field one dimensional pulsed field gradient nuclear magnetic resonance (1D pfg NMR) profilometry, the accuracy of signal acquisition as well as the spatial resolution of a commercial spectrometer operating at 23.4 MHz was investigated. The use of a solid Teflon spacer revealed that the accuracy of signal acquisition was independent of spatial position (height). The standard deviation of distance determinations was less than 150 mu m, whereas the accuracy of water content determination was within 2% in the central part of the detection zone and deteriorated to 4% in the outer parts. The study of aqueous paramagnetic MnCl 2 solutions indicated an exponential relationship between the relative signal intensity and the transverse relaxation decay constant. From this relationship, the relative water content of suspensions could be derived from their signal intensity relative to that of water. Using concentrated paliperidone palmitate dispersions as model suspensions, low-field 1D pfg NMR profilometry has been proven to be suitable for the evaluation of both the sedimentation and resuspendability behavior of viscous, opaque suspensions, for which visual detection of homogeneity may be difficult.}},
  author       = {{Zhu, Wuxin and Martins, José and Saveyn, Pieter and Govoreanu, Ruxandra and Verbruggen, Katrien and Ariën, Tina and Verliefde, Arne and Van der Meeren, Paul}},
  issn         = {{1083-7450}},
  journal      = {{PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY}},
  keywords     = {{nuclear magnetic resonance,Pulsed field gradient,suspension,sediment characterization,sedimentation,resuspendability,IN-OIL MICROEMULSIONS,POLYETHYLENE-GLYCOL,POLYSTYRENE LATEX,DOSE UNIFORMITY,SIZE,MRI,REDISPERSIBILITY,FLOCCULATION,CYCLOHEXANE,PARTICLES}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{787--797}},
  title        = {{Sedimentation and resuspendability evaluation of pharmaceutical suspensions by low-field one dimensional pulsed field gradient NMR profilometry}},
  url          = {{http://doi.org/10.3109/10837450.2011.614252}},
  volume       = {{18}},
  year         = {{2013}},
}

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