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Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis

(2005) JOURNAL OF IMMUNOLOGY. 175(11). p.7642-7649
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Abstract
Acute fulminant liver failure is a serious worldwide health problem. Despite maximal supportive intensive care treatment, the disease offers a poor prognosis, with mortality rates of >80%. We have previously shown that a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) confers complete protection in a mouse model of TNF-induced lethal hepatitis, thereby suggesting the possibility of protecting cancer patients against the deleterious side effects of TNF therapy. In our search for the individual matrix metalloproteinases involved, we found that the recently generated MMP-8-deficient mice are significantly protected against TNF-induced acute hepatitis. In contrast to their wild-type counterparts, MMP-8-null mice display very little hepatocyte necrosis and apoptosis, resulting in a much better survival outcome. We found that these animals clearly display impaired leukocyte influx into the liver and no release of the neutrophil-specific, LPS-induced CXC chemokine. Our findings provide evidence that MMP-8 plays an essential role in acute liver failure and might be a promising new target for the treatment for this illness.
Keywords
MATRIX METALLOPROTEINASES, TUMOR-NECROSIS-FACTOR, NEUTROPHIL COLLAGENASE, RECOMBINANT HUMAN, CXC CHEMOKINES, LIVER-INJURY, IN-VIVO, ALPHA, APOPTOSIS, CELLS

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Citation

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MLA
Van Lint, Philippe, Ben Wielockx, Leen Puimège, et al. “Resistance of Collagenase-2 (matrix Metalloproteinase-8)-deficient Mice to TNF-induced Lethal Hepatitis.” JOURNAL OF IMMUNOLOGY 175.11 (2005): 7642–7649. Print.
APA
Van Lint, P., Wielockx, B., Puimège, L., Noël, A., López-Otin, C., & Libert, C. (2005). Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis. JOURNAL OF IMMUNOLOGY, 175(11), 7642–7649.
Chicago author-date
Van Lint, Philippe, Ben Wielockx, Leen Puimège, Agnès Noël, Carlos López-Otin, and Claude Libert. 2005. “Resistance of Collagenase-2 (matrix Metalloproteinase-8)-deficient Mice to TNF-induced Lethal Hepatitis.” Journal of Immunology 175 (11): 7642–7649.
Chicago author-date (all authors)
Van Lint, Philippe, Ben Wielockx, Leen Puimège, Agnès Noël, Carlos López-Otin, and Claude Libert. 2005. “Resistance of Collagenase-2 (matrix Metalloproteinase-8)-deficient Mice to TNF-induced Lethal Hepatitis.” Journal of Immunology 175 (11): 7642–7649.
Vancouver
1.
Van Lint P, Wielockx B, Puimège L, Noël A, López-Otin C, Libert C. Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis. JOURNAL OF IMMUNOLOGY. 2005;175(11):7642–9.
IEEE
[1]
P. Van Lint, B. Wielockx, L. Puimège, A. Noël, C. López-Otin, and C. Libert, “Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis,” JOURNAL OF IMMUNOLOGY, vol. 175, no. 11, pp. 7642–7649, 2005.
@article{325317,
  abstract     = {{Acute fulminant liver failure is a serious worldwide health problem. Despite maximal supportive intensive care treatment, the disease offers a poor prognosis, with mortality rates of >80%. We have previously shown that a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) confers complete protection in a mouse model of TNF-induced lethal hepatitis, thereby suggesting the possibility of protecting cancer patients against the deleterious side effects of TNF therapy. In our search for the individual matrix metalloproteinases involved, we found that the recently generated MMP-8-deficient mice are significantly protected against TNF-induced acute hepatitis. In contrast to their wild-type counterparts, MMP-8-null mice display very little hepatocyte necrosis and apoptosis, resulting in a much better survival outcome. We found that these animals clearly display impaired leukocyte influx into the liver and no release of the neutrophil-specific, LPS-induced CXC chemokine. Our findings provide evidence that MMP-8 plays an essential role in acute liver failure and might be a promising new target for the treatment for this illness.}},
  author       = {{Van Lint, Philippe and Wielockx, Ben and Puimège, Leen and Noël, Agnès and López-Otin, Carlos and Libert, Claude}},
  issn         = {{0022-1767}},
  journal      = {{JOURNAL OF IMMUNOLOGY}},
  keywords     = {{MATRIX METALLOPROTEINASES,TUMOR-NECROSIS-FACTOR,NEUTROPHIL COLLAGENASE,RECOMBINANT HUMAN,CXC CHEMOKINES,LIVER-INJURY,IN-VIVO,ALPHA,APOPTOSIS,CELLS}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{7642--7649}},
  title        = {{Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis}},
  volume       = {{175}},
  year         = {{2005}},
}

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