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Effect of background region of interest and time-interval selection on glomerular filtration ratio estimation by percentage dose uptake of 99mTc-DTPA in comparison with 51Cr-EDTA clearance in healthy cats

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Abstract
Evaluation of glomerular function is a useful part of the diagnostic approach in animals suspected of having renal disease. Time-interval and background region of interest (bg ROI) selection are determining factors when calculating the glomerular filtration ratio (GFR) based on percentage uptake of (99m)technetium-labelled diethylene triamine penta-acetic acid (Tc-99m-DTPA). Therefore, three different time intervals (60-120 s, 120-180 s, 60-180 s) and three different bg ROIs (C-shape, caudolateral, cranial + caudal) were investigated. In addition, global GFRs based on percentage dose uptake of Tc-99m-DTPA for the different time-intervals and bg ROIs were compared with the global GFR based on (51)chromium-ethylene diaminic tetra-acetic acid (Cr-51-EDTA) plasma clearance in nine healthy European domestic shorthair cats. Paired Student's t-tests and linear regression analysis were used to analyse the data. Different time intervals seemed to cause significant variation (P <0.01) in absolute GFR values, regardless of the choice of bg ROI. Significant differences (P <0.01) between bg ROIs were only observed in the 120-180s time interval between the C-shape and cranial + caudal bg ROI, and between the caudolateral and cranial + caudal bg ROI. The caudolateral bg ROI in the 60-180 s time interval showed the highest correlation coefficient (r = 0.882) between Tc-99m-DTPA and Cr-51-EDTA, although a significant difference (P <0.05) was present between both techniques.
Keywords
HYPERTHYROIDISM, PROPOFOL, PLASMA-CLEARANCE, RENAL-FUNCTION, TC-99M-DIETHYLENETRIAMINEPENTAACETIC ACID, NUCLEAR-MEDICINE, I-131, SCINTIGRAPHY, DOGS

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Chicago
Debruyn, Katrien, Eva Vandermeulen, Jimmy Saunders, André Dobbeleir, Hamphrey Ham, and Kathelijne Peremans. 2013. “Effect of Background Region of Interest and Time-interval Selection on Glomerular Filtration Ratio Estimation by Percentage Dose Uptake of 99mTc-DTPA in Comparison with 51Cr-EDTA Clearance in Healthy Cats.” Journal of Feline Medicine and Surgery 15 (8): 698–705.
APA
Debruyn, K., Vandermeulen, E., Saunders, J., Dobbeleir, A., Ham, H., & Peremans, K. (2013). Effect of background region of interest and time-interval selection on glomerular filtration ratio estimation by percentage dose uptake of 99mTc-DTPA in comparison with 51Cr-EDTA clearance in healthy cats. JOURNAL OF FELINE MEDICINE AND SURGERY, 15(8), 698–705.
Vancouver
1.
Debruyn K, Vandermeulen E, Saunders J, Dobbeleir A, Ham H, Peremans K. Effect of background region of interest and time-interval selection on glomerular filtration ratio estimation by percentage dose uptake of 99mTc-DTPA in comparison with 51Cr-EDTA clearance in healthy cats. JOURNAL OF FELINE MEDICINE AND SURGERY. 2013;15(8):698–705.
MLA
Debruyn, Katrien, Eva Vandermeulen, Jimmy Saunders, et al. “Effect of Background Region of Interest and Time-interval Selection on Glomerular Filtration Ratio Estimation by Percentage Dose Uptake of 99mTc-DTPA in Comparison with 51Cr-EDTA Clearance in Healthy Cats.” JOURNAL OF FELINE MEDICINE AND SURGERY 15.8 (2013): 698–705. Print.
@article{3239261,
  abstract     = {Evaluation of glomerular function is a useful part of the diagnostic approach in animals suspected of having renal disease. Time-interval and background region of interest (bg ROI) selection are determining factors when calculating the glomerular filtration ratio (GFR) based on percentage uptake of (99m)technetium-labelled diethylene triamine penta-acetic acid (Tc-99m-DTPA). Therefore, three different time intervals (60-120 s, 120-180 s, 60-180 s) and three different bg ROIs (C-shape, caudolateral, cranial + caudal) were investigated. In addition, global GFRs based on percentage dose uptake of Tc-99m-DTPA for the different time-intervals and bg ROIs were compared with the global GFR based on (51)chromium-ethylene diaminic tetra-acetic acid (Cr-51-EDTA) plasma clearance in nine healthy European domestic shorthair cats. Paired Student's t-tests and linear regression analysis were used to analyse the data. Different time intervals seemed to cause significant variation (P {\textlangle}0.01) in absolute GFR values, regardless of the choice of bg ROI. Significant differences (P {\textlangle}0.01) between bg ROIs were only observed in the 120-180s time interval between the C-shape and cranial + caudal bg ROI, and between the caudolateral and cranial + caudal bg ROI. The caudolateral bg ROI in the 60-180 s time interval showed the highest correlation coefficient (r = 0.882) between Tc-99m-DTPA and Cr-51-EDTA, although a significant difference (P {\textlangle}0.05) was present between both techniques.},
  author       = {Debruyn, Katrien and Vandermeulen, Eva and Saunders, Jimmy and Dobbeleir, Andr{\'e} and Ham, Hamphrey and Peremans, Kathelijne},
  issn         = {1098-612X},
  journal      = {JOURNAL OF FELINE MEDICINE AND SURGERY},
  keyword      = {HYPERTHYROIDISM,PROPOFOL,PLASMA-CLEARANCE,RENAL-FUNCTION,TC-99M-DIETHYLENETRIAMINEPENTAACETIC ACID,NUCLEAR-MEDICINE,I-131,SCINTIGRAPHY,DOGS},
  language     = {eng},
  number       = {8},
  pages        = {698--705},
  title        = {Effect of background region of interest and time-interval selection on glomerular filtration ratio estimation by percentage dose uptake of 99mTc-DTPA in comparison with 51Cr-EDTA clearance in healthy cats},
  url          = {http://dx.doi.org/10.1177/1098612X13475618},
  volume       = {15},
  year         = {2013},
}

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