Advanced search
1 file | 230.46 KB

Desmopressin melt improves response and compliance compared with tablet in treatment of primary monosymptomatic nocturnal enuresis

(2013) EUROPEAN JOURNAL OF PEDIATRICS. 172(9). p.1235-1242
Author
Organization
Abstract
Primary nocturnal enuresis is a prevalent childhood condition that can persist into adulthood. Desmopressin is an antidiuretic available as orally disintegrating lyophilisate (melt) or solid tablet. Recent findings suggesting different food interactions and clinical characteristics, including compliance, between desmopressin melt and tablet motivated a post hoc analysis of a previously reported randomised, crossover study. The efficacy of desmopressin melt compared with tablet was evaluated using the International Children's Continence Society (ICCS) responder definitions. Compliance was further analysed using detailed criteria, and the association between efficacy and compliance was examined. In total, 221 patients aged 5-15 years, already receiving desmopressin tablets were randomised to the treatment sequence melt (120/240 mu g)/tablet (0.2/0.4 mg) or tablet/melt in two consecutive 3-week periods. The probability of being a responder (partial or full) during either period was significantly more likely with desmopressin melt compared with tablet (odds ratio, 2.0; confidence intervals, 1.07-3.73; p = 0.03). There was no period effect on compliance in the tablet/melt sequence and no difference in the number of completely compliant patients in each formulation group; however, more patients were > 75 % compliant in period 1 compared with period 2 in the melt/tablet sequence. Increased compliance was associated with greater reductions in the number of wet nights for both formulations. Conclusions: Desmopressin melt, compared with tablet, improves the probability of being a responder. Switching from tablet to melt formulation increased patient compliance. Increased compliance was associated with increased efficacy. Switching to desmopressin melt may benefit patients with suboptimal responses to desmopressin tablet.
Keywords
Desmopressin, Enuresis, Compliance, Formulation, CHILDREN, ADOLESCENTS

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 230.46 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Vinter Juul, Kristiaan, Charlotte Van Herzeele, Pauline De Bruyne, Sandra Goble, Johan Vande Walle, and Jens Peter Nørgaard. 2013. “Desmopressin Melt Improves Response and Compliance Compared with Tablet in Treatment of Primary Monosymptomatic Nocturnal Enuresis.” European Journal of Pediatrics 172 (9): 1235–1242.
APA
Vinter Juul, K., Van Herzeele, C., De Bruyne, P., Goble, S., Vande Walle, J., & Nørgaard, J. P. (2013). Desmopressin melt improves response and compliance compared with tablet in treatment of primary monosymptomatic nocturnal enuresis. EUROPEAN JOURNAL OF PEDIATRICS, 172(9), 1235–1242.
Vancouver
1.
Vinter Juul K, Van Herzeele C, De Bruyne P, Goble S, Vande Walle J, Nørgaard JP. Desmopressin melt improves response and compliance compared with tablet in treatment of primary monosymptomatic nocturnal enuresis. EUROPEAN JOURNAL OF PEDIATRICS. 2013;172(9):1235–42.
MLA
Vinter Juul, Kristiaan, Charlotte Van Herzeele, Pauline De Bruyne, et al. “Desmopressin Melt Improves Response and Compliance Compared with Tablet in Treatment of Primary Monosymptomatic Nocturnal Enuresis.” EUROPEAN JOURNAL OF PEDIATRICS 172.9 (2013): 1235–1242. Print.
@article{3235969,
  abstract     = {Primary nocturnal enuresis is a prevalent childhood condition that can persist into adulthood. Desmopressin is an antidiuretic available as orally disintegrating lyophilisate (melt) or solid tablet. Recent findings suggesting different food interactions and clinical characteristics, including compliance, between desmopressin melt and tablet motivated a post hoc analysis of a previously reported randomised, crossover study. The efficacy of desmopressin melt compared with tablet was evaluated using the International Children's Continence Society (ICCS) responder definitions. Compliance was further analysed using detailed criteria, and the association between efficacy and compliance was examined. In total, 221 patients aged 5-15 years, already receiving desmopressin tablets were randomised to the treatment sequence melt (120/240 mu g)/tablet (0.2/0.4 mg) or tablet/melt in two consecutive 3-week periods. The probability of being a responder (partial or full) during either period was significantly more likely with desmopressin melt compared with tablet (odds ratio, 2.0; confidence intervals, 1.07-3.73; p = 0.03). There was no period effect on compliance in the tablet/melt sequence and no difference in the number of completely compliant patients in each formulation group; however, more patients were {\textrangle} 75 \% compliant in period 1 compared with period 2 in the melt/tablet sequence. Increased compliance was associated with greater reductions in the number of wet nights for both formulations. Conclusions: Desmopressin melt, compared with tablet, improves the probability of being a responder. Switching from tablet to melt formulation increased patient compliance. Increased compliance was associated with increased efficacy. Switching to desmopressin melt may benefit patients with suboptimal responses to desmopressin tablet.},
  author       = {Vinter Juul, Kristiaan and Van Herzeele, Charlotte and De Bruyne, Pauline and Goble, Sandra and Vande Walle, Johan and N{\o}rgaard, Jens Peter},
  issn         = {0340-6199},
  journal      = {EUROPEAN JOURNAL OF PEDIATRICS},
  language     = {eng},
  number       = {9},
  pages        = {1235--1242},
  title        = {Desmopressin melt improves response and compliance compared with tablet in treatment of primary monosymptomatic nocturnal enuresis},
  url          = {http://dx.doi.org/10.1007/s00431-013-1992-9},
  volume       = {172},
  year         = {2013},
}

Altmetric
View in Altmetric
Web of Science
Times cited: