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The effect of blood pressure regulation during aortic coarctation repair on brain, kidney, and muscle oxygen saturation measured by near-infrared spectroscopy: a randomized, clinical trial

Anneliese Moerman (UGent) , Thierry Bové (UGent) , Katrien Francois (UGent) , STEFAN JACOBS (UGent) , ISABEL DEBLAERE (UGent) , Patrick Wouters (UGent) and Stefan De Hert (UGent)
(2013) ANESTHESIA AND ANALGESIA. 116(4). p.760-766
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Abstract
BACKGROUND: In this study, we compared the effects of 3 frequently used. arterial blood pressure regulating agents on brain (rS(c)O(2)), renal (SrO2), and muscle (SmO2) oxygen saturation, during aortic coarctation repair in children. Based on the reported adverse effect of sodium nitroprusside (SNP) on left-sided rS(c)O(2) during aortic coarctation repair, we tested the hypothesis that the alterations in left rS(c)O(2) occurring with SNP would not be present with sevoflurane and nitroglycerin (NTG). Additionally, we explored the effects of blood pressure regulation with SW NTG, or sevoflurane on right-sided rS(c)O(2), SrO2, and SmO2. METHODS: Children with isolated aortic coarctation undergoing surgical repair through a left thoracotomy without the use of cardiopulmonary bypass were considered eligible for the study. During aortic cross-clamping, control of mean arterial blood pressure (MAP) was conducted according to randomization by the use of SNP NTG, or sevoflurane to obtain a mean target right brachial blood pressure of 120% to 150% of the MAP value before cross-clamping. Bilateral rS(c)O(2), SrO2, and SmO2 were recorded continuously with near-infrared spectroscopy. As a primary end point, the maximal relative change in left-sided rS(c)O(2) in response to aortic cross-clamping was compared among treatment groups. RESULTS: Ten patients per group were included. No significant difference among treatment groups was observed in maximal relative change in left-sided rS(c)O(2) (SNP versus sevoflurane: mean difference -0.7%, 99% confidence interval [CI] -31% to 29%, P = 1.0; SNP versus NTG: mean difference -1.8%, 99% CI -32% to 28%, P = 1.0; sevoflurane versus NTG: mean difference -1.1%, 99% CI -31% to 29%, P = 1.0). Additional analyses also detected no difference between groups in right rS(c)O(2) (P = 0.4). Compared with NTG, treatment with SNP resulted in a significantly larger (-64%+/- 17% vs -34%+/- 25%, P = 0.01) and faster (-9 +/- 4%.min(-1) vs -4 +/- 3%.min(-1), P = 0.004) decrease in SmO2. Right-sided rS(c)O(2) and MAP showed a poor correlation for NTG (r = -0.2, P = 0.93), whereas borderline for sevoflurane (r = 0.44, P = 0.09) and SNP (r = 0.56, P = 0.04). CONCLUSIONS: The mean differences in left-sided rS(c)O(2) among the patients treated with SNP, NTG, or sevoflurane for proximal hypertension during aortic cross-clamping were no more than 32%. Additional analysis demonstrated a low MAP-rS(c)O(2) dependence with the use of NTG. Because NTG also resulted in a smaller and slower decrease of oxygen saturation in peripheral tissues, our data suggest that its use might be preferable for proximal blood pressure control during surgical procedures involving aortic cross-clamping.
Keywords
spectroscopy, near-infrared, coarctation, blood pressure, nitroglycerin, sodium nitroprusside

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Chicago
Moerman, Anneliese, Thierry Bové, Katrien Francois, STEFAN JACOBS, ISABEL DEBLAERE, Patrick Wouters, and Stefan De Hert. 2013. “The Effect of Blood Pressure Regulation During Aortic Coarctation Repair on Brain, Kidney, and Muscle Oxygen Saturation Measured by Near-infrared Spectroscopy: a Randomized, Clinical Trial.” Anesthesia and Analgesia 116 (4): 760–766.
APA
Moerman, Anneliese, Bové, T., Francois, K., JACOBS, S., DEBLAERE, I., Wouters, P., & De Hert, S. (2013). The effect of blood pressure regulation during aortic coarctation repair on brain, kidney, and muscle oxygen saturation measured by near-infrared spectroscopy: a randomized, clinical trial. ANESTHESIA AND ANALGESIA, 116(4), 760–766.
Vancouver
1.
Moerman A, Bové T, Francois K, JACOBS S, DEBLAERE I, Wouters P, et al. The effect of blood pressure regulation during aortic coarctation repair on brain, kidney, and muscle oxygen saturation measured by near-infrared spectroscopy: a randomized, clinical trial. ANESTHESIA AND ANALGESIA. 2013;116(4):760–6.
MLA
Moerman, Anneliese, Thierry Bové, Katrien Francois, et al. “The Effect of Blood Pressure Regulation During Aortic Coarctation Repair on Brain, Kidney, and Muscle Oxygen Saturation Measured by Near-infrared Spectroscopy: a Randomized, Clinical Trial.” ANESTHESIA AND ANALGESIA 116.4 (2013): 760–766. Print.
@article{3234350,
  abstract     = {BACKGROUND: In this study, we compared the effects of 3 frequently used. arterial blood pressure regulating agents on brain (rS(c)O(2)), renal (SrO2), and muscle (SmO2) oxygen saturation, during aortic coarctation repair in children. Based on the reported adverse effect of sodium nitroprusside (SNP) on left-sided rS(c)O(2) during aortic coarctation repair, we tested the hypothesis that the alterations in left rS(c)O(2) occurring with SNP would not be present with sevoflurane and nitroglycerin (NTG). Additionally, we explored the effects of blood pressure regulation with SW NTG, or sevoflurane on right-sided rS(c)O(2), SrO2, and SmO2. 
METHODS: Children with isolated aortic coarctation undergoing surgical repair through a left thoracotomy without the use of cardiopulmonary bypass were considered eligible for the study. During aortic cross-clamping, control of mean arterial blood pressure (MAP) was conducted according to randomization by the use of SNP NTG, or sevoflurane to obtain a mean target right brachial blood pressure of 120\% to 150\% of the MAP value before cross-clamping. Bilateral rS(c)O(2), SrO2, and SmO2 were recorded continuously with near-infrared spectroscopy. As a primary end point, the maximal relative change in left-sided rS(c)O(2) in response to aortic cross-clamping was compared among treatment groups. 
RESULTS: Ten patients per group were included. No significant difference among treatment groups was observed in maximal relative change in left-sided rS(c)O(2) (SNP versus sevoflurane: mean difference -0.7\%, 99\% confidence interval [CI] -31\% to 29\%, P = 1.0; SNP versus NTG: mean difference -1.8\%, 99\% CI -32\% to 28\%, P = 1.0; sevoflurane versus NTG: mean difference -1.1\%, 99\% CI -31\% to 29\%, P = 1.0). Additional analyses also detected no difference between groups in right rS(c)O(2) (P = 0.4). Compared with NTG, treatment with SNP resulted in a significantly larger (-64\%+/- 17\% vs -34\%+/- 25\%, P = 0.01) and faster (-9 +/- 4\%.min(-1) vs -4 +/- 3\%.min(-1), P = 0.004) decrease in SmO2. Right-sided rS(c)O(2) and MAP showed a poor correlation for NTG (r = -0.2, P = 0.93), whereas borderline for sevoflurane (r = 0.44, P = 0.09) and SNP (r = 0.56, P = 0.04). 
CONCLUSIONS: The mean differences in left-sided rS(c)O(2) among the patients treated with SNP, NTG, or sevoflurane for proximal hypertension during aortic cross-clamping were no more than 32\%. Additional analysis demonstrated a low MAP-rS(c)O(2) dependence with the use of NTG. Because NTG also resulted in a smaller and slower decrease of oxygen saturation in peripheral tissues, our data suggest that its use might be preferable for proximal blood pressure control during surgical procedures involving aortic cross-clamping.},
  author       = {Moerman, Anneliese and Bov{\'e}, Thierry and Francois, Katrien and JACOBS, STEFAN and DEBLAERE, ISABEL and Wouters, Patrick and De Hert, Stefan},
  issn         = {0003-2999},
  journal      = {ANESTHESIA AND ANALGESIA},
  keyword      = {spectroscopy,near-infrared,coarctation,blood pressure,nitroglycerin,sodium nitroprusside},
  language     = {eng},
  number       = {4},
  pages        = {760--766},
  title        = {The effect of blood pressure regulation during aortic coarctation repair on brain, kidney, and muscle oxygen saturation measured by near-infrared spectroscopy: a randomized, clinical trial},
  url          = {http://dx.doi.org/10.1213/ANE.0b013e31827f5628},
  volume       = {116},
  year         = {2013},
}

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